Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1

Food and Chemical Toxicology

Volumn 44, Issue 9, 2006, Pages 1474-1484

  Peterson, Sabrina ^a,b   Lampe, Johanna W ^a,b   Bammler, Theo K ^a   Gross Steinmeyer, Kerstin ^a   Eaton, David L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Aflatoxin; Apiaceae; Carrot; CYP1A2; Flavonoid; Furanocoumarin

Indexed keywords

AFLATOXIN B1; APIGENIN; BERGAPTEN; CAFFEIC ACID; CHLOROGENIC ACID; CYTOCHROME P450 1A2; CYTOCHROME P450 INHIBITOR; METHOXSALEN; NARINGENIN; PLANT MEDICINAL PRODUCT; PSORALEN; QUERCETIN;

ALLELE; ARTICLE; AUXOTROPHY; CELL SURVIVAL; CONTROLLED STUDY; DIPLOIDY; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FOOD INTAKE; GENE CONVERSION; GENE MUTATION; HETEROLOGOUS EXPRESSION; IN VIVO STUDY; MICROSOME; MUTAGENICITY; NONHUMAN; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; STATISTICAL SIGNIFICANCE; VEGETABLE; YEAST;

AFLATOXIN B1; APIACEAE; BIOTRANSFORMATION; CELL SURVIVAL; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES; MUTAGENS; OXIDOREDUCTASES; PLANT EXTRACTS; POISONS; PSORALENS; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE;

APIUM GRAVEOLENS VAR. DULCE; DAUCUS CAROTA; PETROSELINUM CRISPUM; SACCHAROMYCES CEREVISIAE;

EID: 33745617086     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.04.010     Document Type: Article

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