Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids

Biochemical Pharmacology

Volumn 55, Issue 9, 1998, Pages 1369-1375

  Lee, Ho ^a   Yeom, Hyeyeong ^a   Kim, Young Goo ^a   Yoon, Chang No ^a   Jin, Changbae ^a   Choi, Jae Sue ^b   Kim, Bok Ryang ^c   Kim, Dong Hyun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Pukyong National University   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

Caffeine N3 demethylation; Flavonoids; Inhibition; QSAR

Indexed keywords

2 AMINO 3,4 DIMETHYLIMIDAZO[4,5 F]QUINOLINE; APIGENIN; AVICULARINE; BIOCHANIN A; CAFFEINE; CHRYSIN; CYTOCHROME P450; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; FISETIN; FLAVONOID; GALANGIN; GUAIYAVERIN; HESPERETIN; HESPERIDIN; KAEMPFEROL; LUTEOLIN; MORIN; MYRICETIN; NARINGENIN; PANASENOSIDE; POPULNIN; PRUNIN; QUERCETIN; QUERCITRIN; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; DEMETHYLATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GLYCOSYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTICARCINOGENIC AGENTS; CAFFEINE; CYTOCHROME P-450 CYP1A2; FLAVONOIDS; HUMANS; KINETICS; MICROSOMES, LIVER; REGRESSION ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032499398     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00644-8     Document Type: Article

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