Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations

Diabetes

Volumn 47, Issue 2, 1998, Pages 230-238

  Mantzoros, Christos S ^a   Frederich, Robert C ^a   Qu, Daqing ^b   Lowell, Bradford B ^a   Maratos Flier, Eleftheria ^b   Flier, Jeffrey S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; DIPHTHERIA TOXIN; GLUCOSE; INSULIN; LEPTIN; NEUROPEPTIDE Y; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY EXPENDITURE; FEMALE; HYPERLIPIDEMIA; HYPERPHAGIA; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN RESISTANCE; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0031890721     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.47.2.230     Document Type: Article

References (47)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse ob gene and its human homologue. Nature 372:425-432, 1994
2. Flier JS: Leptin expression and action: new experimental paradigms. Proc Natl Acad Sci USA 94:4242-1245, 1997
3. Caro JF, Sinha MK, Kolaczynski JW, Zhary PL, Considine RV: Leptin: the tale of an obesity gene. Diabetes 45:1455-1462, 1996
4. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone KL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
5. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
6. Campfield L A, Smith F J, Guisez Y, Devos R, Burn P: Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-548, 1995
7. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL: Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 90:2065-2070, 1995
8. Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS: Expression of ob mRNA and its encoded protein in rodents: impact of nutrition and obesity. J Clin Invest 96:1658-1663, 1995
9. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM: Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161, 1995
10. Wu-Peng XS, Chua SC, Okada N, Liu SM, Nicolson M, Leibel RL: Phenotype of the obese Koletsky (f) rat due to Tyr763Stopp mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes 46:513-518, 1997
11. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM: Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635, 1996
12. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the leptin receptor identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495, 1996
13. Frederich RC, Hamann A, Anderson S, Lollman B, Lowell BB, Flier JS: Leptin reflects body lipid content in mice: evidence for diet-induced leptin resistance. Nat Med 1:1311-1314, 1995
14. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohanessian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295, 1996
15. Rohner-Jeanrenaud F, Jeanrenaud B: Obesity, leptin and the brain. N Engl J Med 334:324-325, 1996
16. Himms-Hagen J: Brown adipose tissue thermogenesis and obesity. Prog Lipid Res 28:67-115, 1989
17. Lowell BB, Flier JS: The potential significance of β3 adrenergic receptors. J Clin Invest 95:923, 1995
18. Himms-Hagen J: Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats: a new hypothesis that links thermostatic and glucostatic hypotheses for control of food intake. Proc Soc Exp Biol Med 208:159-169, 1995
19. Rothwell NJ, Le Feuvre RA: Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies. Int J Obes Relat Metab Disord 19 (Suppl. 3): S67-S71, 1992
20. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS: Role of leptin in fat regulation. Nature 380:677, 1996
21. Lowell BB, Susulic V, Hammann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP, Flier JS: Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1366:740-742, 1993
22. Hamann A, Flier JS, Lowell BB: Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes and hyperlipidemia. Endocrinology 137:21-29, 1996
23. Hamann A, Benecke H, Le Marchand-Brustel Y, Susulic VS, Lowell BB, Flier JS: Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat. Diabetes 44:1266-1273, 1995
24. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF: Neuropeptide Y chronically injected in the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:1189-1192, 1986
25. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung KM, Kriauciunas A, MacKellar W, Rosteck PR Jr, Schoner B, Smith D, Tinsley FC, Zhang X-Y, Heiman M: The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377:530-532, 1995
26. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ, Weigle DS: Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535, 1996
27. Wang Q, Bing C, Al-Barazanji K, Mossakowaska DE, Wang XM, McBay DL, Neville WA, Taddayon M, Pickavance L, Dryden S, Thomas ME, McHalle MT, Gloyer IS, Wilson S, Buckingham R, Arch JR, Trayhurn P, Williams G: Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes 46:335-341, 1997
28. 3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 45:909-914, 1996
29. Castrucci AM, Labl M, Hruby VJ, Matsunaga TO, Hadley M: Melanin concentrating hormone. III. Melanin concentrating hormone: the message sequence. Life Sci 45:1141-1148, 1989
30. Corder R, Gaillard RC, Bohlen P: Isolation and sequence of rat peptide YY and neuropeptide Y. Regul Pept 21:253-261, 1988
31. Anima R, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS: Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252, 1996
32. Chua SC, White DW, Wu-Peng X, Liu SM, Okada N, Kershaw EE, Chung WK, Power-Kehoe L, Chua M, Tartaglia LA, Leibel RL: Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45:1141-1143, 1996
33. Hamann A, Busing B, Kausch C, Ertl J, Preibisch G, Greten H, Matthaci S: Chronic leptin treatment does not prevent the development of obesity in transgenic mice with brown fat deficiency. Diabetologia 40:810-815, 1997
34. Houseknecht KL, Mantzoros CS, Kuliawat R, Hadro E, Flier JS, Kahn BB: Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes 45:1638-1643, 1996
35. Sinha MK, Opentanova I, Ohanessian JP, Kolaczynski JW, Heiman ML, Hate J, Becker GW, Bowsher RR, Stephens TW, Caro JF: Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short-term fasting. J Clin Invest 98:1277-1282, 1996
36. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311, 1996
37. Golden PL, Maccagnan TJ, Pardridge WM: Human blood-brain barrier leptin receptor binding and endocytosis in isolated human brain microvessels. J Clin Invest 99:14-18, 1997
38. Caro JF, Kolaczynski JW, Nyce MR, Ohanessian JP, Opentanova I, Goldman WH, Lynn RR, Zhang PL, Sinha MK, Considine RV: Decreased cerebrospinal fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348:159-161, 1996
39. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte D: Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 2:589-593, 1996
40. Vaisse C, Halaas JL, Horvath CM, Darnell JE Jr, Stoffel M, Friedman JM: Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 14:95-97, 1996
41. Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, Graziano MP, Sybertz EJ, Strader CD, Davis HR: Diet-induced obese mice develop peripheral but not central resistance to leptin. J Clin Invest 99:385-390, 1997
42. Erickson J, Clegg K, Palmiter R: Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415-418, 1996
43. Erickson JC, Hollopeter G, Palmiter RD: Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y Science 274:1704-1707, 1996
44. Saito M, Bray GA: Diurnal rhythm for corticosterone in obese (ob/ob) diabetes (db/db) and gold thioglucose induced obesity in mice. Endocrinology 113:2181-2185, 1983
45. Licinio J, Mantzoro CS, Negrao AB, Cizza G, Wong M-L, Bongiorno P, Chrousos G, Karp B, Allen C, Flier JS, Gold PW: Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 3:575-579, 1997
46. Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M: Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46:313-316, 1997
47. Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH: Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94:4637-4641, 1997