Validating cancer drug targets

Nature

Volumn 441, Issue 7092, 2006, Pages 451-456

  Benson, John D ^a   Chen, Ying Nan P ^a   Cornell Kennon, Susan A ^a   Dorsch, Marion ^a   Kim, Sunkyu ^a   Leszczyniecka, Magdalena ^a   Sellers, William R ^a   Lengauer, Christoph ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEDICAL APPLICATIONS; ONCOLOGY; RESEARCH AND DEVELOPMENT MANAGEMENT; TUMORS;

CANCER RESEARCH PROGRAMS; DRUG DISCOVERY PROGRAM; THERAPEUTIC AGENTS;

DRUG PRODUCTS;

ANTIESTROGEN; BEVACIZUMAB; BICALUTAMIDE; ERLOTINIB; FLUTAMIDE; GEFITINIB; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; IMATINIB; LETROZOLE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; RAPAMYCIN; RETINOIC ACID; RITUXIMAB; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SORAFENIB; SUNITINIB; TAMOXIFEN; TRASTUZUMAB; TUMOR NECROSIS FACTOR ALPHA;

CANCER; DRUG;

APOPTOSIS; B CELL LEUKEMIA; B CELL LYMPHOMA; BREAST CANCER; CANCER; CANCER CELL CULTURE; CANCER RESEARCH; CANCER THERAPY; CARCINOGENESIS; CHROMOSOME REARRANGEMENT; CHRONIC MYELOID LEUKEMIA; COLON CANCER; COLORECTAL CANCER; DNA REPLICATION; DNA STRUCTURE; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVITY; EPIGENETICS; GASTROINTESTINAL STROMAL TUMOR; GENE AMPLIFICATION; GENE MUTATION; GENE SEGREGATION; GENE TRANSLOCATION; GENETIC ASSOCIATION; GENETIC LINKAGE; HUMAN; KIDNEY CARCINOMA; NONHODGKIN LYMPHOMA; NONHUMAN; ONCOGENE; PANCREAS CANCER; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; ANIMAL; CELL; DISEASE MODEL; DRUG EFFECT; DRUG SCREENING; ENZYME SPECIFICITY; GENETICS; METABOLISM; METHODOLOGY; NEOPLASM; PATHOLOGY; REPRODUCIBILITY; STANDARD;

ANIMALS; CELLS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HUMANS; NEOPLASMS; REPRODUCIBILITY OF RESULTS; SUBSTRATE SPECIFICITY;

EID: 33745323666     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04873     Document Type: Review

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