-
1
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I. & Landis, J. Can the pharmaceutical industry reduce attrition rates? Nature Rev. Drug Discov. 3, 711-715 (2004).
-
(2004)
Nature Rev. Drug Discov.
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
2
-
-
0036014978
-
Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia
-
Gorre, M. E. & Sawyers, C. L. Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia. Curr. Opin. Hematol. 9, 303-307 (2002).
-
(2002)
Curr. Opin. Hematol.
, vol.9
, pp. 303-307
-
-
Gorre, M.E.1
Sawyers, C.L.2
-
3
-
-
0038647568
-
Consequences of nonadaptive alterations in cancer
-
Kamb, A. Consequences of nonadaptive alterations in cancer. Mol. Biol. Cell. 14, 2201-2205 (2003).
-
(2003)
Mol. Biol. Cell.
, vol.14
, pp. 2201-2205
-
-
Kamb, A.1
-
4
-
-
7244243743
-
Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials
-
Roberts Jr., T. G. et al. Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials. JAMA 292, 2130-2140 (2004).
-
(2004)
JAMA
, vol.292
, pp. 2130-2140
-
-
Roberts Jr., T.G.1
-
5
-
-
4544227574
-
Toward large-scale modeling of the microbial cell for computer simulation
-
Ishii, N., Robert, M., Nakayama, Y., Kanai, A. & Tomita, M. Toward large-scale modeling of the microbial cell for computer simulation. J. Biotechnol. 113, 281-294 (2004).
-
(2004)
J. Biotechnol.
, vol.113
, pp. 281-294
-
-
Ishii, N.1
Robert, M.2
Nakayama, Y.3
Kanai, A.4
Tomita, M.5
-
6
-
-
0141566685
-
Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models
-
Oskoglou-Nomikos, T., Pater, J. L. & Seymour, L. Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models. Clin. Cancer Res. 9 4227-4239 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 4227-4239
-
-
Oskoglou-Nomikos, T.1
Pater, J.L.2
Seymour, L.3
-
7
-
-
10444261212
-
Development of TGF-β signaling inhibitors for cancer therapy
-
Yingling, J. M., Blanchard, K. L. & Sawyer, J. S. Development of TGF-β signaling inhibitors for cancer therapy. Nature Rev. Drug Discov. 3, 1011-1022.
-
Nature Rev. Drug Discov.
, vol.3
, pp. 1011-1022
-
-
Yingling, J.M.1
Blanchard, K.L.2
Sawyer, J.S.3
-
8
-
-
1942422737
-
Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development
-
Peterson, J. K. & Houghton, P. J. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. Eur. J. Cancer 40, 837-844 (2004).
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 837-844
-
-
Peterson, J.K.1
Houghton, P.J.2
-
9
-
-
4344623889
-
Imatinib as a paradigm of targeted therapies
-
Druker, B. J. Imatinib as a paradigm of targeted therapies. Adv. Cancer Res. 91, 1-30 (2004).
-
(2004)
Adv. Cancer Res.
, vol.91
, pp. 1-30
-
-
Druker, B.J.1
-
10
-
-
2342500837
-
Predictive factors for epidermal growth factor receptor inhibitors - The bull's-eye hits the arrow
-
Dancey, J. E. Predictive factors for epidermal growth factor receptor inhibitors - the bull's-eye hits the arrow. Cancer Cell 5, 411-415 (2004).
-
(2004)
Cancer Cell
, vol.5
, pp. 411-415
-
-
Dancey, J.E.1
-
11
-
-
0035899418
-
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
-
Tuveson, D. A. et al. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene 20, 5054-5058 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 5054-5058
-
-
Tuveson, D.A.1
-
12
-
-
4043184022
-
FLT3 tyrosine kinase as a target in acute leukemias
-
Griffin, J. D. FLT3 tyrosine kinase as a target in acute leukemias. Hematol. J. 5, S188-190 (2004).
-
(2004)
Hematol. J.
, vol.5
-
-
Griffin, J.D.1
-
13
-
-
0035257549
-
Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trials
-
Slamon, D. & Pegram, M. Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trials. Semin. Oncol. 28, 13-19 (2001).
-
(2001)
Semin. Oncol.
, vol.28
, pp. 13-19
-
-
Slamon, D.1
Pegram, M.2
-
14
-
-
0345600892
-
Resistance to imatinib (Glivec): Update on clinical mechanisms
-
Weisberg, E. & Griffin, J. D. Resistance to imatinib (Glivec): update on clinical mechanisms. Drug Resist. Updat. 6 231-238 (2003).
-
(2003)
Drug Resist. Updat.
, vol.6
, pp. 231-238
-
-
Weisberg, E.1
Griffin, J.D.2
-
15
-
-
0034088857
-
A gene expression database for the molecular pharmacology of cancer
-
Scherf, U. et al. A gene expression database for the molecular pharmacology of cancer. Nature Genet. 24, 236-244 (2000).
-
(2000)
Nature Genet.
, vol.24
, pp. 236-244
-
-
Scherf, U.1
-
16
-
-
0036549015
-
Conditional mouse models of sporadic cancer
-
Jonkers, J. & Berns, A. Conditional mouse models of sporadic cancer. Nature Rev. Cancer 2, 251-265.
-
Nature Rev. Cancer
, vol.2
, pp. 251-265
-
-
Jonkers, J.1
Berns, A.2
-
17
-
-
2042458747
-
Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
-
Johnson, J. I. et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. Br. J. Cancer 84, 1424-1431 (2001)
-
(2001)
Br. J. Cancer
, vol.84
, pp. 1424-1431
-
-
Johnson, J.I.1
|