Anergic T cells act as suppressor cells in vitro and in vivo

European Journal of Immunology

Volumn 29, Issue 2, 1999, Pages 686-692

  Chai, Jian Guo ^a   Bartok, Istvan ^b   Chandler, Phillip ^b   Vendetti, Silvia ^a   Antoniou, Antony ^b   Dyson, Julian ^b   Lechler, Robert ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Anergy; CD4+ T cell; Murine; Skin graft rejection; Suppression

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CLONAL ANERGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLOGRAFT; SUPPRESSOR CELL; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; GRAFT REJECTION; ISOANTIGENS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; SKIN TRANSPLANTATION; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS;

EID: 0033032992     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199902)29:02<686::AID-IMMU686>3.0.CO;2-N     Document Type: Article

References (40)

1. Charlton, B., Auchincloss Jr., H. and Fathman, C. G., Mechanisms of transplantation tolerance. Annu. Rev. Immunol. 1994. 12: 707-734.
2. Cobbold, S. P., Adams, E., Marshall, S. E., Davis, J. D. and Waldmann, H., Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8. Immunol. Rev. 1996. 149: 5-33.
3. Qin, S., Cobbold, S. P., Pope, H., Elliott, J., Kioussis, D. and Waldmann, H., "Infectious" transplantation tolerance. Science 1993. 259: 974-977.
4. Chen, Y., Kuchroo, V. K., Inobe, J.-I., Hafler, D. A. and Weiner, H. L., Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994. 265: 1237-1240.
5. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997. 389: 737-742.
6. Davis, J. D., Leong, L. Y. W., Mellor, A., Cobbold, S. P. and Waldmann, H., T cell suppression in transplantation tolerance through linked recognition. J. Immunol. 1996. 156: 3602-3607.
7. Davis, J. D., Martin, G., Phillips, J., Marshall, S. E., Cobbold, S. P. and Waldmann, H., T cell regulation in adult transplantation tolerance. J. Immunol. 1996. 157: 529-533.
8. Chen, N. and Field, E., Enhanced type 2 and diminished type 1 cytokines in neonatal tolerance. Transplantation 1995. 59: 933-941.
9. Powell, T. J. and Streilein, J. W., Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells. J. Immunol. 1990. 144: 854-859.
10. Maeda, H., Takata, M., Takahashi, S., Ogoshi, S. and Fujimoto, S. Adoptive transfer of a Th2-like cell line prolongs MHC class II antigen disparate skin allograft survival in the mouse. Int. Immunol. 1994. 6: 855-862.
11. Sayegh, M. H., Akalin, E., Hancock, W. W., Russell, M. E., Carpenter, C. B., Linsley, P. S. and Turka, T. A., CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 1995. 181: 1869-1874.
12. Onodera, K., Hancock, W. H., Graser, E., Lehmann, M., Sayegh, M. H., Strom, T. B., Volk, H.-D. and Kupiec-Weglinski, J. W., Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients. J. Immunol. 1997. 158: 1572-1581.
13. + T cell-mediated graft rejection. Eur. J. Immunol. 1997. 27: 1663-1670.
14. Weiner, H. L., Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol. Today 1997. 18: 335-343.
15. Strom, T. B., Roy-Chaudhury, P., Robert, M., Zheng, X. X., Nickerson, P. W., Wood, K. and Bushell, A., The Th1/Th2 paradigm and the allograft response. Curr. Opin. Immunol. 1996. 8: 688-693.
16. Piccotti, J. R., Chan, S. Y., Vanbuskirk, A. M., Eichwald, E. J. and Bishop, D. K., Are Th2 helper T lymphocytes beneficial, deleterious, or irrelevant in promoting allograft survival? Transplantation 1997. 63: 619-624.
17. + T cells or B cells. J. Immunol. 1998. 16: 1868-1874.
18. Piccotti, J. R., Chan, S. Y., Goodman, R. E., Megram, J., Eichwald, E. J. and Biship, D. K., II-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection: evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J. Immunol. 1996. 157: 1951-1957.
19. Steiger, J., Nickerson, P. W., Steurer, W., Moscovitch-Lopatin, M. and Strom, T. B., IL-2 knockout recipient mice reject islet allografts. J. Immunol 1992. 155: 489.
20. Slaeem, S., Konieczny, B. T., Lowry, R. P., Baddoura, F. K. and Lakkis, F. G., Acute rejection of vascularized herat allografts in the absence of IFN-γ. Transplantation 1996. 62: 1908-1911.
21. Zheng, X. X., Steele, A. W., Nickerson, P. W., Steurer, W., Steiger, J. and Strom, T. B., Administration of non cytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J. Immunol. 1995. 154: 5590-5600.
22. Muller, R., Davies, J. D., Krahl, T. and Sarvetnick, N., IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection. J. Immunol. 1997. 159: 1599-1603.
23. Nickerson, P., Zheng, X. X., Steiger, J., Steele, A. W., Steurer, W., Roy-Chaudhury, P., Muller, W. and Strom, T. B., Prolonged islet allograft acceptance in the absence of IL-4 expression. Transpl. Immunol. 1996. 4: 81-85.
24. Lakkis, F. G., Konieczny, B. T., Lowry, R. P., Linsley, P. R., Linsley, P. S., Alexander, D. Z., Pearson, T. L. and Larson, C. P., Prolonged cardiac allografts survival in IL-4 gene knockout mice treated with CTLA-Ig. J. Immunol. 1997. 158: 2443-2448.
25. Lombardi, G., Sidhu, S., Batchelor, R. and Lechler, R., Anergic T cells as suppressor cells in vitro. Science 1994. 264: 1587-1589.
26. Frasca, L., Carmichael, P., Lechler, R. and Lombardi, G., Anergic T cells effect linked suppression. Eur. J. lmmunol. 1997. 27: 3191-3197.
27. Jenkins, M. K., Chen, C., Jung, G., Mueller, D. L. and Schwarte, R. H., Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol. 1990. 144: 16-22.
28. + T cells. Int. Immunol. 1997. 9: 935-944.
29. Buer, J., Lanoue, A., Franzke, A., Garcia, C., von Boehmer, H. and Sarukhan, A., Interleukin 10 secretion and imparied effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J. Exp. Med. 1998. 187: 177-183.
30. Waldmann, H., Cobbold, S., Benjamin, R. and Qin, S., A theoretical framework for selftolerance and its relevance to therapy of autoimmune disease. J. Autoimmun. 1988. 1: 623-629.
31. Antoniou, A. N., Elliott, J., Rosmarakis, E. and Dyson, P. J., H-2 Aγ diabetogenic residue 57 asp/non-asp dimorphism influences T cell recognition and selection. Immunogenetics 1997. 47: 218-225.
32. Dailey, M. O., Fathman, G., Butcher, E. C., Pillemer, E. and Weissman, I., Abnormal migration of T lymphocyte clones. J. Immunol. 1982. 128: 2134-2136.
33. Dailey, M. O., Gallatin, W. M. and Weissman, I. L., The in vivo behavior of T cell clones: altered migration due to loss of the lymphocyte surface homing receptor. J. Mol. Cell, Immunol. 1985. 2: 27-36.
34. Gallatin, W. M., Weissman, I. L. and Butcher, E. C., A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 1983. 304: 30-34.
35. Sakaguchi, S., Toda, M., Asano, M., Itoh, M., Morse, S. S. and Sakaguchi, N., T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases. J. Autoimmun. 1996. 9: 211-220.
36. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol 1998. 160: 1212-1218.
37. g7 βchain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. J. Immunol. 1995. 154: 5567-5575.
38. Tomonari, K., T cell receptor expressed on an autoreactive T cell clone, clone 4. I. Induction of various T cell receptorfunctions by anti-T idiotype antibodies. Cell Immunol. 1985. 96: 147-162.
39. Mosmann, T., Schumacher, J. H., Fiorentino, D. F., Leverah, J., Morre, K. W. and Bond, M. W., Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6 and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid radioimmunoadsorbent assay. J. Immunol. 1990. 145: 2938-2945.
40. Simpson, E. and Chandler, P., Analysis of allograft responses in vivo and in vitro. In Herzenberg, L. A., Weir, D. M., Herzenberg, L. A. and Blackwell, C. (Eds.) Immunochemistry and Molecular Immunology. Blackwell Science, Cambridge 1996, pp 139.1-139.10.