Bystander sensitization to activation-induced cell death as a mechanism of virus-induced immune suppression

Journal of Virology

Volumn 74, Issue 8, 2000, Pages 3650-3658

  Zarozinski, Christopher C ^a,b   McNally, James M ^a   Lohman, Barbara L ^a,c   Daniels, Keith A ^a   Welsh, Raymond M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; EXPERIMENTAL MODEL; FLOW CYTOMETRY; LEUKOCYTE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN-PRESENTING CELLS; APOPTOSIS; CARRIER STATE; CD8-POSITIVE T-LYMPHOCYTES; FAS LIGAND PROTEIN; FEMALE; IMMUNE TOLERANCE; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SPLEEN;

EID: 0034111526     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.8.3650-3658.2000     Document Type: Article

References (39)

1. Akbar, A. N., N. Borthwick, M. Salmon, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pett, J. E. Grundy, and G. Janossy. 1993. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J. Exp. Med. 179:427-438.
2. Bruce, J., F. W. Symington, T. J. McKearn, and J. Sprent. 1981. A monoclonal antibody discriminating between subsets of T and B cells. J. Immunol. 127:2496-2501.
3. Ehl, S., J. Hombach, P. Aichele, H. Hengartner, and R. M. Zinkernagel. 1997. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J. Exp. Med. 185:1241-1251.
4. Finkel, T. H., G. Tudor-Williams, N. K. Banda, M. F. Cotton, T. Monks, T. W. Baba, R. M. Ruprecht, and A. Kupfer. 1995. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV and SIV infected lymph nodes. Nat. Med. 1:129-134.
5. Fugier-Viver, I., C. Severt-Delprat, P. Rivailler, M. Rissoan, Y. Liu, and C. Rabourdin-Combe. 1997. Measles virus suppresses cell-mediated immunity by interfering with survival and functions of dendritic and T cells. J. Exp. Med. 186:813-823.
6. + T cells. J. Exp. Med. 186:801-812.
7. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp. Med. 175:331-340.
8. Gruters, R. A., F. G. Terpsta, R. De Jong, C. J. M. von Nossel, R. A. W. van Lier, and F. Miedema. 1990. Selective loss of T cell functions in different stages of HIV infection. Eur. J. Immunol. 20:1039-1044.
9. Inaba, K., and R. M. Steinman. 1984. Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release. J. Exp. Med. 160:1717-1735.
10. Jacobs, R. P., and G. A. Cole. 1976. Lymphocytic choriomeningitis virus-induced immunosuppression: a virus-induced macrophage defect. J. Immunol. 117:1004-1009.
11. Jamieson, B. D., and R. Ahmed. 1988. T-cell tolerance: exposure to virus in utero does not cause a permanent deletion of specific T cells. Proc. Natl. Acad. Sci. USA 85:2265-2268.
12. Jamieson, B. D., T. Somasundaram, and R. Ahmed. 1991. Abrogation of tolerance to a chronic viral infection. J. Immunol. 147:3521-3529.
13. Karp, C. L., M. Wysocka, L. M. Wahl, J. M. Ahearn, P. J. Cumo, B. Sherry, G. Trinchieri, and D. E. Griffin. 1996. Mechanism of suppression of cell-mediated immunity to measles virus. Science 273:228-231.
14. King, C., B. D. Jamieson, K. Reddy, N. Bali, R. J. Concepcion, and R. Ahmed. 1992. Viral infection of the thymus. J. Virol. 66:3155-3160.
15. Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353:858-851.
16. Lenardo, M. J. 1997. The molecular regulation of lymphocyte apoptosis. Semin. Immunol. 9:1-5.
17. + T cells from HIV-infected persons. J. Immunol. 153:412-420.
18. Liu, Y., and C. A. Janeway. 1990. Interferon γ plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J. Exp. Med. 172:1735-1739.
19. Lohman, B. L., and R. M. Welsh. 1998. Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice. J. Virol. 72:7815-7821.
20. Lynch, D. H., M. L. Watson, M R. Alderson, P. R. Baum, R. E. Miller, T. Tough, M. Gibson, T. Davis-Smith, C. A. Smith, K. Hunter, D. Bhat, W. Din, R. G. Goodwin, and M. F. Seidin. 1994. The mouse Fas-ligand gene is mutated in gld mice as is part of a TNF family gene cluster. Immunity 1: 131-136.
21. Meyaard, L., S. A. Otto, R. R. Jonker, M. J. Mijnster, R. P. M. Keet, and F. Miedema. 1992. Programmed death of T cells in HIV-1 infection. Science 257:217-219.
22. Muller, U., U. Steinhoff, L. F. L. Reiss, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918-1921.
23. Murali-Krishna, K., J. D. Altman, M. Suresh, D. Sourdive, A. J. Zajac, J. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a re-evaluation of bystander activation during viral infection. Immunity 8:177-187.
24. Razvi, E. S., Z. Jiang, B. A. Woda, and R. M. Welsh. 1995 Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice. Am. J. Pathol. 147:79-91.
25. Razvi, E. S., and R. M. Welsh. 1993. Programmed cell death of T lymphocytes during acute viral infection: a mechanism fur virus-induced immune deficiency. J. Virol. 67:5754-5765.
26. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225-1228.
27. Rouse, B. T., and D. W. Horohov. 1986. Immunosuppression during viral infections. Rev. Infect. Dis. 8:850-873.
28. Saron, M., B. Shidani, M. A. Nahori, J. Guillon, and P. Truffa-Bachi. 1990. Lymphocytic choriomeningitis virus-induced immunodepression: inherent defect in B and T lymphocytes. J. Virol. 64:4076-4083.
29. Selin, L. K., S. R. Nahill, and R. M. Welsh. 1994. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179:1933-1943.
30. Selin, L. K., K. Vergilis, R. M. Welsh, and S. R. Nahill. 1996. Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte (CTL) memory by heterologous viral infections. J. Exp. Med. 183:2489-2500.
31. Takahasi, T., M. Tanaka, C. I. Brannan, N. A. Jenkins, N. G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice caused by a point mutation in the Fas ligand. Cell 76:969-976.
32. Tough, D. L., P. Borrow, and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272:1947-1950.
33. van Nossel, C. J. M., R. A. Gruters, F. G. Terpstra, P. T. A. Schellekens, R. A. W. van Lier, and F. Miedema. 1990. Functional and phenotypic evidence for a selective loss of memory T cells in different stages of HIV infection. J. Clin. Investig. 86:293-299.
34. high γδ T cells in lyme arthritis. J. Exp. Med. 184:2109-2117.
35. von Pirquet, C. 1908. Das Verhalten der kutanen Tuberkulin-Reakton wahrend der Masern. Dtsch. Med. Wochenschr. 34:1297-1300.
36. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317.
37. Watanabe-Fukunaga, R., T. Suda, H. Hashimoto, and S. Nagata. 1995. Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders. EMBO J. 14:12-18.
38. Zarozinski, C. C., and R. M. Welsh. 1997. Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response. J. Exp. Med. 185:1629-1639.
39. Zinkernagel, R. M., and R. M. Welsh. 1976. H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D. J. Immunol. 117:1495-1502.