Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor

Journal of Immunology

Volumn 167, Issue 5, 2001, Pages 2714-2723

  Moon, J J ^a   Nelson, B H ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D2; CYCLIN D3; CYCLIN E; INTERLEUKIN 2 RECEPTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN P27; PROTEIN SHC; STAT5 PROTEIN; THYMIDINE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL LINE; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035451818     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.5.2714     Document Type: Article

References (60)

1. Biology of the interleukin-2 receptor
2. 1 cyclins in primary T cells is not blocked by rapamycin or cyclosporin A
3. Cancer cell cycles
4. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
5. 1-phase progression
6. The regulation of E2F by pRB-family proteins
7. Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling
8. Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation
9. Jaks and STATs: Biological implications
10. Different interleukin 2 receptor β-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation
11. Distinct tyrosine residues within the interleukin-2 receptor β chain drive signal transduction specificity, redundancy, and diversity
12. ras during T-cell activation and growth
13. The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc
14. The docking molecule gab2 is induced by lymphocyte activation and is involved in signaling by interleukin-2 and interleukin-15 but not other common γ chain-using cytokines
15. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
16. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5
17. Regulation of transcription by MAP kinase cascades
18. Ras regulation and function in lymphocytes
19. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
20. Transcriptional regulation by extracellular signals: Mechanisms and specificity
21. Cell cycle targets of Ras/Raf signalling
22. Regulation of c-myc expression by Ras/Raf signalling
23. Structure and function of phosphoinositide 3-kinases
24. Cellular survival: A play in three Akts
25. Mammalian target of rapamycin: Immunonosuppressive drugs uncover a novel pathway of cytokine receptor signaling
26. Ribosomal S6 kinase signaling and the control of translation
27. Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase
28. S6K-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts
29. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
30. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
31. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt
32. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
33. c chain sufficient for Jak kinase activation and induction of proliferation in T cells
34. c chain for Janus kinase activation leading to T cell proliferation
35. Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling
36. Shc contains two grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes
37. A synthetic inhibitor of the mitogen-activated protein kinase cascade
38. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002)
39. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
40. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
41. Critical role of the interleukin 2 (IL-2) receptor γ-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction
42. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase
43. Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2
44. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
45. L induction
46. Expression of c-Myc in response to colony-stimulating factor-1 requires mitogen-activated protein kinase kinase-1
47. MAPK pathway
48. Complementation of defective colony-stimulating factor 1 receptor signaling and mitogenesis by Raf and v-Src
49. 1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 activity
50. Cyclin E-induced S phase without activation of the pRb/E2F pathway
51. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
52. 1IS-promoting mechanism parallel to the pRb/E2F pathway
53. Cell growth: Downstream of Myc: To grow or to cycle?
54. Drosophila myc regulates cellular growth during development
55. PIP2 and PIP3: Complex roles at the cell surface
56. Ras effectors
57. 1 cell cycle progression
58. A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes
59. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
60. IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3′-kinase, and Grb2