Kinetic perspectives of T cell antigen receptor signaling: A two-tier model for T cell full activation

Immunological Reviews

Volumn 191, Issue , 2003, Pages 196-210

  Iwashima, Makio ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; RAF PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIGEN RECOGNITION; CYTOKINE PRODUCTION; HUMAN; LYMPHOCYTE DIFFERENTIATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; HUMANS; INTERLEUKIN-2; KINETICS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 0037306145     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2003.00024.x     Document Type: Review

References (156)

1. Sette A, et al. Antigen analogs/MHC complexes as specific T cell receptor antagonists. Annu Rev Immunol 1994;12:413-431.
2. Jameson SC, Bevan MJ. T cell receptor antagonists and partial agonists. Immunity 1995;2:1-11.
3. Germain RN. The T cell receptor for antigen. signaling and ligand discrimination. J Biol Chem 2001;276:35223-35226.
4. Madrenas J, Schwartz RH, Germain RN. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists. Proc Natl Acad Sci USA 1996;93:9736-9741.
5. Boussiotis VA, et al. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science 1994;266:1039-1042.
6. Beverly B, Kang SM, Lenardo MJ, Schwartz RH. Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int Immunol 1992;4:661-671.
7. DeSilva DR, Urdahl KB, Jenkins MK. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J Immunol 1991;147:3261-3267.
8. Lanzavecchia A, Lezzi G, Viola A. From TCR engagement to T cell activation. a kinetic view of T cell behavior. Cell 1999;96:1-4.
9. Lanzavecchia A. Understanding the mechanisms of sustained signaling and T cell activation. J Exp Med 1997;185:1717-1719.
10. Ullman KS, Northrop JP, Verweij CL, Crabtree GR. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu Rev Immunol 1990;8:421-452.
11. Kelly K, Siebenlist U. Immediate-early genes induced by antigen receptor stimulation. Curr Opin Immunol 1995;7:327-332.
12. Jain J, Loh C, Rao A. Transcriptional regulation of the IL-2 gene. Curr Opin Immunol 1995;7:333-342.
13. Venkataraman L, Burakoff SJ, Sen R. FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells. J Exp Med 1995;181:1091-1099.
14. Kang SM, et al. Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen. Mol Cell Biol 1992;12:3149-3154.
15. Samelson LE. Signal transduction mediated by the T cell antigen receptor: the role of adap ter proteins. Annu Rev Immunol 2002;20:371-394.
16. Qian D, Weiss A. T cell antigen receptor signal transduction. Curr Opin Cell Biol 1997;9:205-212.
17. Straus DB, Weiss A. Genetic evidence for the involvement of the Lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 1992;70:585-593.
18. Wange RL, Malek SN, Desiderio S, Samelson LE. Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor and CD3 from activated Jurkat T cells. J Biol Chem 1993;268:19797-19801.
19. Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 1994;263:1136-1139.
20. Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70kd protein-tyrosine kinase that associates with the TCR chain. Cell 1992;71:649-662.
21. + thymic selection in humans lacking Zap-70 kinase. Cell 1994;76:947-958.
22. Chan AC, et al. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 1994;264:1599-1601.
23. Eider ME, Lin D, Clever J, et al. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 1994;264:1596-1599.
24. Negishi I, et al. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 1995;376:435-438.
25. Wardenburg JB, et al. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J Biol Chem 1996;271:19641-19644.
26. Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. LAT, the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998;92:83-92.
27. Zhang W, Trible RP, Samelson LE. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 1998;9:239-246.
28. Lin J, Weiss A, Finco TS. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J Biol Chem 1999;274:28861-28864.
29. Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE. Association of Grb2, Gads, and phospholipase C-γ1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J Biol Chem 2000;275:23355-23361.
30. Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A. LAT is required for TCR-mediated activation of PLCγ 1 and the Ras pathway. Immunity 1998;9:617-626.
31. Liu SK, Berry DM, McGlade CJ. The role of Gads in hematopoietic cell signalling. Oncogene 2001;20:6284-6290.
32. Koretzky GA. The role of Grb2-associated proteins in T-cell activation. Immunol Today 1997;18:401-406.
33. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 1993;363:45-51.
34. Liu SK, McGlade CJ. Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc. Oncogene 1998;17:3073-3082.
35. Liu SK, Fang N, Koretzky GA, McGlade CJ. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr Biol 1999;9:67-75.
36. Liu SK, Smith CA, Arnold R, Kiefer F, McGlade CJ. The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR. J Immunol 2000;165:1417-1426.
37. Koretzky GA, Boerth NJ. The role of adapter proteins in T cell activation. Cell Mol Life Sci 1999;56:1048-1060.
38. Jackman JK, et al. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem 1995;270:7029-7032.
39. Clements JL, et al. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 1998;281:416-419.
40. Koretzky GA, Myung PS. Positive and negative regulation of T-cell activation by adaptor proteins. Nat Rev Immunol 2001;1:95-107.
41. Griffiths EK, Penninger JM. Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr Opin Immunol 2002;14:317-322.
42. Burack WR, Cheng AM, Shaw AS. Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr Opin Immunol 2002;14:312-316.
43. Griffiths EK, Penninger JM. Adapting TCR signaling to integrins. Sci STKE 2002;127:RE3.
44. Yablonski D, Kuhne MR, Kadlecek T, Weiss A. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell. Science 1998;281:413-416.
45. Lin J, Weiss A. Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem 2001;276:29588-29595.
46. Nishibe S, Wahl MI, Hernandez-Sotomayor SM, Tonks NK, Rhee SG, Carpenter G. Increase of the catalytic activity of phospholipase C-γ1 by tyrosine phosphorylation. Science 1990;250:1253-1256.
47. Schaeffer EM, et al. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 1999;284:638-641.
48. Liu KQ, Bunnell SC, Gurniak CB, Berg LJ. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J Exp Med 1998;187:1721-1727.
49. Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell 2002;109:S67-S79.
50. Ebinu JO, et al. RasGRP links T-cell receptor signaling to Ras. Blood 2000;95:3199-3203.
51. Dower NA, et al. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol 2000;1:317-321.
52. Isakov N, Altman A. Protein kinase C (θ) in T cell activation. Annu Rev Immunol 2002;20:761-794.
53. Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998;395:82-86.
54. Monks CR, Kupfer H, Tamir I, Barlow A, Kupfer A. Selective modulation of protein kinase C-θ during T-cell activation. Nature 1997;385:83-86.
55. Sun Z, et al. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 2000;404:402-407.
56. Macian F, Lopez-Rodriguez C, Rao A. Partners in transcription: NFAT and AP-1. Oncogene 2001;20:2476-2489.
57. Ghosh S, May MJ, Kopp EB. NF-κ B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16:225-260.
58. Whitney RB, Sutherland RM. Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin. J Cell Physiol 1972;80:329-337.
59. Aramburu J, Rao A, Klee CB. Calcineurin: from structure to function. Curr Topics Cell Regul 2000;36:237-295.
60. Bootman MD, et al. Calcium signalling - an overview. Semin Cell Dev Biol 2001;12:3-10.
61. Peng SL, Gerth AJ, Ranger AM, Glimcher LH. NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity 2001;14:13-20.
62. Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH. The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity 1998;9:295-304.
63. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 1997;15:707-747.
64. Klemm JD, Beals CR, Crabtree GR. Rapid targeting of nuclear proteins to the cytoplasm. Curr Biol 1997;7:638-644.
65. Garcia-Rodriguez C, Rao A. Requirement for integration of phorbol 12-myristate 13-acetate and calcium pathways is preserved in the transactivation domain of NFAT1. Eur J Immunol 2000;30:2432-2436.
66. Okamura H, et al. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell 2000;6:539-550.
67. Chinenov Y, Kerppola TK. Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity. Oncogene 2001;20:2438-2452.
68. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995;270:16483-16486.
69. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995;80:179-185.
70. Rincon M, Flavell RA. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J 1994;13:4370-4381.
71. Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994;77:727-736.
72. Gaide O, et al. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation. Nat Immunol 2002;3:836-843.
73. Shapiro VS, Truitt KE, Imboden JB, Weiss A. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol 1997;17:4051-4058.
74. McGuire KL, Iacobelli M. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J Immunol 1997;159:1319-1327.
75. Altman A, Isakov N, Baier G. Protein kinase Cθ: a new essential superstar on the T-cell stage. Immunol Today 2000;21:567-573.
76. Ruland J, et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure. Cell 2001;104:33-42.
77. Wang D, et al. A requirement for carma1 TCR-induced NF-κB activation. Nat Immunol 2002;3:830-835.
78. Dimitratos SD, Woods DF, Stathakis DG, Bryant PJ. Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family. Bioessays 1999;21:912-921.
79. Ghosh S, Karin M. Missing pieces in the NF-κB puzzle. Cell 2002;109:S81-S96.
80. Kane LP, Lin J, Weiss A. It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation. Trends Immunol 2002;23:413-420.
81. Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines. Nat Immunol 2001;2:37-44.
82. Kane LP, Shapiro VS, Stokoe D, Weiss A. Induction of NF-κB by the Akt/PKB kinase. Curr Biol 1999;9:601-604.
83. Scherer DC, Brockman JA, Bendall HH, Zhang GM, Ballard DW, Oltz EM. Corepression of RelA and c-rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes. Immunity 1996;5:563-574.
84. Brockman JA, et al. Coupling of a signal response domain in Iκ Bα to multiple pathways for NF-κ B activation. Mol Cell Biol 1995;15:2809-2818.
85. Boothby MR, Mora AL, Scherer DC, Brockman JA, Ballard DW. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF) -κB. J Exp Med 1997;185:1897-1907.
86. Weiss A, Shields R, Newton M, Manger B, Imboden J. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. J Immunol 1987;138:2169-2176.
87. Goldsmith MA, Weiss A. Early signal transduction by the antigen receptor without commitment to T cell activation. Science 1988;240:1029-1031.
88. +1. J Immunol 1993;150:5338-5349.
89. Valitutti S, Dessing M, Aktories K, Gallati H, Lanzavecchia A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J Exp Med 1994;181:577-584.
90. Angkachatchai V, Finkel TH. ADP-ribosylation of rho by C3 ribosyltransferase inhibits IL-2 production and sustained calcium influx in activated T cells. J Immunol 1999;163:3819-3825.
91. Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 1997;385:169-172.
92. Costello PS, et al. The Rho-famlly GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways. Proc Natl Acad Sci USA 1999;96:3035-3040.
93. + signals and immunosuppression. Nature 1996;383:837-840.
94. Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 1997;275:1930-1934.
95. Ohteki T, et al. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med 2000;192:99-104.
96. Berg NN, Puente LG, Dawicki W, Ostergaard HL. Sustained TCR signaling is required for mitogen-activated protein kinase activation and degranulation by cytotoxic T lymphocytes. J Immunol 1998;161:2919-2924.
97. Ward Y, Gupta S, Jensen P, Wartmann M, Davis RJ, Kelly K. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature 1994;367:651-654.
98. Rohan PJ, et al. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science 1993;259:1763-1766.
99. Pages G, et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 1999;286:1374-1377.
100. Shao H, Wilkinson B, Lee B, Han PC, Kaye J. Slow accumulation of active mitogen-activated protein kinase during thymocyte differentiation regulates the temporal pattern of transcription factor gene expression. J Immunol 1999;163:603-610.
101. Backstrom BT, Muller U, Hausmann B, Palmer E. Positive selection through a motif in the αβ T cell receptor. Science 1998;281:835-838.
102. Delgado P, Fernandez E, Dave V, Kappes D, Alarcon B. CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Nature 2000;406:426-430.
103. Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, Crabtree GR. Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol Cell Biol 1988;8:1715-1724.
104. Corcoran LM, Karvelas M. Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. Immunity 1994;1:635-645.
105. Bhargava AK, Li Z, Weissman SM. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. Proc Natl Acad Sci USA 1993;90:10260-10264.
106. Zwilling S, Dieckmann A, Pfisterer P, Angel P, Wirth T. Inducible expression and phosphorylation of coactivator BOB. 1/OBF.1 in T cells. Science 1997;277:221-225.
107. Nielsen PJ, Georgiev O, Lorenz B, Schaffner W. B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1. Eur J Immunol 1996;26:3214-3218.
108. Gerondakis S, Strasser A, Metcalf D, Grigoriadis G, Scheerlinck JY, Grumont RJ. Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA 1996;93:3405-3409.
109. Kontgen F, et al. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev 1995;9:1965-1977.
110. Liou HC, Jin Z, Tumang J, Andjelic S, Smith KA, Liou ML. c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol 1999;11:361-371.
111. He YW, Beers C, Deftos ML, Ojala EW, Forbush KA, Bevan MJ. Down-regulation of the orphan nuclear receptor RORγt is essential for T lymphocyte maturation. J Immunol 2000;164:5668-5674.
112. Bull P, Morley KL, Hoekstra MF, Hunter T, Verma IM. The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. Mol Cell Biol 1990;10:5473-5485.
113. Martin AG, Fresno M. Tumor necrosis factor-α activation of NF-κB requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel. J Biol Chem 2000;275:24383-24391.
114. Tam WF, Wang W, Sen R. Cell-specific association and shuttling of IκBα provides a mechanism for nuclear NF-κB in B lymphocytes. Mol Cell Biol 2001;21:4837-4846.
115. Tam WF, Sen R. IκB family members function by different mechanisms. J Biol Chem 2001;276:7701-7704.
116. Pelicci G, et al. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 1992;70:93-104.
117. Bonfini L, Migliaccio E, Pelicci G, Lanfrancone L, Pellcci P. Not all Shc's roads lead to Ras. T1BS 1996;21:257-261.
118. Milia E, et al. The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation. Oncogene 1996;13:767-775.
119. Pratt JC, van den Brink MR, Igras VE, Walk SF, Ravichandran KS, Burakoff SJ. Requirement for Shc in TCR-mediated activation of a T cell hybridoma. J Immunol 1999;163:2586-2591.
120. Ravichandran KS, Lee KK, Songyang Z, Cantley LC, Burn P, Burakoff SJ. Interaction of Shc with the chain of the T cell receptor upon T cell activation. Science 1993;262:902-905.
121. Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol Cell Biol 1995;15:593-600.
122. Walk SF, March ME, Ravichandran KS. Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc. Eur J Immunol 1998;28:2265-2275.
123. Plyte S, et al. Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts. Oncogene 2000;19:1529-1537.
124. Ravinhandran KS. Signaling via Shc family adapter proteins. Oncogene 2001;20:6322-6330.
125. Baldari CT, Telford JL. Lymphocyte antigen receptor signal integration and regulation by the SHC adaptor. Biol Chem 1999;380:129-134.
126. Zhang L, Camerini B, Bender TP, Ravinhandran KS. A nonredundant role for the adapter protein Shc in thymic T cell development. Nat Immunol 2002;3:749-755.
127. Iwashima M, et al. Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression. Proc Natl Acad Sci USA 2002;99:4544-4549.
128. Castellanos MC, Munoz C, Montoya MC, Lara-Pezzi E, Lopez-Cabrera M, Landazuri MO. Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1. J Immunol 1997;159:5463-5473.
129. Leonard WJ, Kronke M, Peffer NJ, Depper JM, Greene WC. Interleukin 2 receptor gene expression in normal human T lymphocytes. Proc Natl Acad Sci USA 1985;82:6281-6285.
130. John S, et al. Regulation of cell-type-specific interleukin-2 receptor α-chain gene expression: potential role of physical interactions between Elf-1, HMG-I (Y), and NF-κB family proteins. Mol Cell Biol 1995;15:1786-1796.
131. Thompson CB, et al. cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol Cell Biol 1992;12:1043-1053.
132. Rellahan BL, Jensen JP, Howcroft TK, Singer DS, Bonvini E, Weissman AM. Elf-1 regulates basal expression from the T cell antigen receptor ζ-chain gene promoter. J Immunol 1998;160:2794-2801.
133. Juang YT, Solomou EE, Rellahan B, Tsokos GC. Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR ζ-chain. J Immunol 2002;168:2865-2871.
134. Kwon B, Youn BS, Kwon BS. Functions of newly identified members of the tumor necrosis factor receptor/ligand superfamilies in lymphocytes. Curr Opin Immunol 1999;11:340-345.
135. Lobo FM, Zanjani R, Ho N, Chatila TA, Fuleihan RL. Calcium-dependent activation of TNF family gene expression by Ca2+/calmodulin kinase type IV/Gr and calcineurin. J Immunol 1999;162:2057-2063.
136. Tsytsykova AV, Tsitsikov EN, Geha KS. The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription. J Biol Chem 1996;271:3763-3770.
137. Tocci MJ, et al. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J Immunol 1989;143:718-726.
138. Hampl J, Chien YH, Davis MM. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 1997;7:379-385.
139. Rosette C, et al. The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model. Immunity 2001;15:59-70.
140. Diehn M, et al. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci USA 2002;99:11796-11801.
141. Umlauf SW, Beverly B, Kang SM, Brorson K, Tran AC, Schwartz RH. Molecular regulation of the IL-2 gene: rheostatic control of the immune system. Immunol Rev 1993;133:177-197.
142. Umlanf SW, Beverly B, Lantz O, Schwartz RH. Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics. Mol Cell Biol 1995;15:3197-3205.
143. Kiernan RE, et al. Post-activation turn-off of NF-κB-dependent transcription is regulated by acetylation of p65. J Biol Chem 2002;in press http://www.jbc.org/cgi/reprint/M209572200v1.pdf.
144. Bromley SK, et al. The immunological synapse. Annu Rev Immunol 2001;19:375-396.
145. Lee KH, Holdorf AD, Dustin ML, Chan AC, Allen PM, Shaw AS. T cell receptor signaling precedes immunological synapse formation. Science 2002;295:1539-1542.
146. Grakoui A, et al. The immunological synapse: a molecular machine controlling T cell activation. Science 1999;285:221-227.
147. Bernhagen J, Calandra T, Bucala R. Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features. J Mol Med 1998;76:151-161.
148. Bacher M, et al. An essential regulatory role for macrophage migration inhibitory factor in T-cell activation. Proc Natl Acad Sci USA 1996;93:7849-7854.
149. Mitchell RA, Metz CN, Peng T, Bucala R. Sustained mitogen-activated protein kinase (MAPK) and cytoplasmic phospholipase A2 activation by macrophage migration inhibitory factor (MIF). Regulatory role in cell proliferation and glucocorticoid action. J Biol Chem 1999;274:18100-18106.
150. de Jong YP, et al. Development of chronic colitis is dependent on the cytokine MIF. Nat Immunol 2001;2:1061-1066.
151. Horak I, Lohler J, Ma A, Smith KA. Interleukin-2 deficient mice. a new model to study autoimmunity and self-tolerance. Immunol Rev 1995;148:35-44.
152. + T cells. J Exp Med 1997;186:757-766.
153. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J Exp Med 1995;182:1579-1584.
154. Yamashita M, Hashimoto K, Kimura M, Kubo M, Tada T, Nakayama T. Requirement for p56 (lck) tyrosine kinase activation in Th subset differentiation. Int Immunol 1998;10:577-591.
155. Yamashita M, et al. T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J Exp Med 2000;191:1869-1879.
156. Yamashita M, et al. T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc Natl Acad Sci USA 1999;96:1024-1029.