The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: Evidence for a conserved subdomain, the A-loop in the ATP-binding cassette

Biochemistry

Volumn 45, Issue 24, 2006, Pages 7605-7616

  Kim, In Wha ^a   Peng, Xiang Hong ^a,b   Sauna, Zuben E ^a   FitzGerald, Peter C ^a   Xia, Di ^a   Müller, Marianna ^a,c   Nandigama, Krishnamachary ^a   Ambudkar, Suresh V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL MEDICAL CENTER   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; BIOLOGICAL MEMBRANES; CELLS; FLUORESCENCE; HYDROLYSIS; MUTAGENESIS;

MUTANT PROTEINS; NUCLEOTIDE-BINDING DOMAIN (NBD); TRANSIENT EXPRESSION; TYROSINE;

PROTEINS;

2' O (TRINITROPHENYL)ADENOSINE 5' TRIPHOSPHATE; ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ALANINE; AROMATIC AMINO ACID; CYSTEINE; GLYCOPROTEIN P; MUTANT PROTEIN; NUCLEOTIDE; PHENYLALANINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; VANADIC ACID;

A LOOP; AMINO ACID SUBSTITUTION; ANIMAL CELL; AROMATIC RESIDUE INTERACTING WITH THE ADENINE RING OF ATP DOMAIN; ARTICLE; CONSENSUS SEQUENCE; CRYSTAL STRUCTURE; FLUORESCENCE; GENE EXPRESSION; GENE EXPRESSION SYSTEM; GENETIC CONSERVATION; HYDROLYSIS; INFORMATION PROCESSING; INSECT CELL; NONHUMAN; NUCLEOTIDE BINDING DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DATABASE; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN SUBDOMAIN; SEQUENCE ALIGNMENT; VACCINIA VIRUS; WALKER A DOMAIN;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BACULOVIRIDAE; BASE SEQUENCE; CONSERVED SEQUENCE; DIMERIZATION; HELA CELLS; HUMANS; HYDROLYSIS; INSECTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEIN; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRYPSIN; TYROSINE; VACCINIA VIRUS;

INSECTA; MAMMALIA; VACCINIA VIRUS;

EID: 33745174833     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060308o     Document Type: Article

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