The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding

FEBS Letters

Volumn 580, Issue 4, 2006, Pages 1049-1055

  Ambudkar, Suresh V ^a   Kim, In Wha ^a   Xia, Di ^a   Sauna, Zuben E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

ABC transporter; ATP hydrolysis; Homology modeling; Multidrug resistance; Nucleotide binding domain; Sequence alignment

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; AROMATIC CARBOXYLIC ACID; GLYCOPROTEIN P; NUCLEOTIDE BINDING PROTEIN; PROTEIN WALKER A; TYROSINE; UNCLASSIFIED DRUG;

BINDING AFFINITY; HUMAN; MULTIDRUG RESISTANCE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN HYDROLYSIS; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; SHORT SURVEY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ATP-BINDING CASSETTE TRANSPORTERS; HYDROLYSIS; MODELS, MOLECULAR; P-GLYCOPROTEIN; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 31844443618     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.12.051     Document Type: Short Survey

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