Functionally Similar Vanadate-induced 8-Azidoadenosine 5′-[α -32P]Diphosphate-trapped Transition State Intermediates of Human P-glycoprotein are Generated in the Absence and Presence of ATP Hydrolysis

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21199-21208

  Sauna, Zuben E ^b   Smith, Melissa M ^b   Müller, Marianna ^b   Ambudkar, Suresh V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG PRODUCTS; GLUCOSE; HYDROLYSIS; PROTEINS; SUBSTRATES; TUMORS;

NUCLEOTIDES;

BIOCHEMISTRY;

2'(3') O (2,4,6 TRINITROPHENYL)ADENOSINE TRIPHOSPHATE; 8 AZIDOADENOSINE 5' DIPHOSPHATE; 8 AZIDOADENOSINE TRIPHOSPHATE; ADENOSINE DERIVATIVE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; GLYCOPROTEIN P; IODINE 125; MULTIDRUG RESISTANCE PROTEIN 1; PHOSPHORUS 32; PRAZOSIN; UNCLASSIFIED DRUG; VANADIC ACID; 8 AZIDOADENOSINE DIPHOSPHATE; 8-AZIDOADENOSINE 5'-TRIPHOSPHATE; 8-AZIDOADENOSINE DIPHOSPHATE; AZIDE; DRUG DERIVATIVE; PHOSPHORUS; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; INSECT CELL; MULTIDRUG RESISTANCE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; AFFINITY LABELING; ANIMAL; BINDING SITE; CELL LINE; CELL MEMBRANE; CHEMISTRY; GENETIC TRANSFECTION; INSECT; KINETICS; METABOLISM; THERMODYNAMICS;

ANIMALIA; INSECTA; ARRHENIUS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AFFINITY LABELS; ANIMALS; AZIDES; BINDING SITES; CELL LINE; CELL MEMBRANE; HELA CELLS; HUMANS; HYDROLYSIS; INSECTS; KINETICS; P-GLYCOPROTEINS; PHOSPHORUS RADIOISOTOPES; RECOMBINANT PROTEINS; THERMODYNAMICS; TRANSFECTION; VANADATES;

EID: 0035877703     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100886200     Document Type: Article

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