메뉴 건너뛰기




Volumn 31, Issue 3, 2006, Pages 189-199

Genetic factors for overweight and CAD

Author keywords

CAD; Genetics; Obesity

Indexed keywords

ADIPOCYTE; ARTICLE; BODY WEIGHT; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; COMORBIDITY; CORONARY ARTERY DISEASE; DEVELOPING COUNTRY; DISEASE ASSOCIATION; DNA POLYMORPHISM; EVALUATION; EXTENDED FAMILY; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC LINKAGE; GENETICS; GENOME; HEART INFARCTION; HEREDITY; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INFLAMMATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE; RECEPTOR GENE; RISK FACTOR; SIBLING; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 33745122556     PISSN: 03409937     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00059-006-2797-7     Document Type: Article
Times cited : (6)

References (100)
  • 1
    • 0032577311 scopus 로고    scopus 로고
    • As obesity rates rise, experts struggle to explain why
    • Taubes G. As obesity rates rise, experts struggle to explain why. Science 1998;280:1367-8.
    • (1998) Science , vol.280 , pp. 1367-1368
    • Taubes, G.1
  • 2
    • 0032453237 scopus 로고    scopus 로고
    • Type II diabetes,essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": The "thrifty genotype" hypothesis enters the 21st century
    • Neel JV, Weder AB, Julius S. Type II diabetes,essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": the "thrifty genotype" hypothesis enters the 21st century. Perspect Biol Med 1998;42:44-74.
    • (1998) Perspect Biol Med , vol.42 , pp. 44-74
    • Neel, J.V.1    Weder, A.B.2    Julius, S.3
  • 3
    • 0042697368 scopus 로고    scopus 로고
    • Perspectives: Molecular genetic research in human obesity
    • Hebebrand J, Friedel S, Schauble N, et al. Perspectives: molecular genetic research in human obesity. Obes Rev 2003;4:139-46.
    • (2003) Obes Rev , vol.4 , pp. 139-146
    • Hebebrand, J.1    Friedel, S.2    Schauble, N.3
  • 4
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the house mouse. J Hered 1950;41:317-8.
    • (1950) J Hered , vol.41 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 5
    • 0014004384 scopus 로고
    • Diabetes, a new mutation in the mouse
    • Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science 1966;153:1127-8.
    • (1966) Science , vol.153 , pp. 1127-1128
    • Hummel, K.P.1    Dickie, M.M.2    Coleman, D.L.3
  • 6
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973;9:294-8.
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.L.1
  • 7
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • Chua SC Jr, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271:994-6.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua Jr., S.C.1
  • 8
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia LA, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-71.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1
  • 9
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1
  • 10
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague CT, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903-8.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1
  • 11
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obesity
    • Strobel A, Issad T, Camoin L, et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998;18:213-5.
    • (1998) Nat Genet , vol.18 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3
  • 12
    • 0033575993 scopus 로고    scopus 로고
    • Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    • Farooqi IS, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-84.
    • (1999) N Engl J Med , vol.341 , pp. 879-884
    • Farooqi, I.S.1
  • 13
    • 0035514934 scopus 로고    scopus 로고
    • Partial leptin deficiency and human adiposity
    • Farooqi IS, et al. Partial leptin deficiency and human adiposity. Nature 2001;414:34-5.
    • (2001) Nature , vol.414 , pp. 34-35
    • Farooqi, I.S.1
  • 14
    • 12144289998 scopus 로고    scopus 로고
    • Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    • U S A
    • Licinio J, et al. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A 2004;101:4531-6.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 4531-4536
    • Licinio, J.1
  • 15
    • 0027049534 scopus 로고
    • Molecular characterization of the mouse agouti locus
    • Bultman SJ, Michaud EJ, Woychik RP. Molecular characterization of the mouse agouti locus. Cell 1992;71:1195-204.
    • (1992) Cell , vol.71 , pp. 1195-1204
    • Bultman, S.J.1    Michaud, E.J.2    Woychik, R.P.3
  • 16
    • 0027256438 scopus 로고
    • Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation
    • Miller MW, et al. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 1993;7:454-67.
    • (1993) Genes Dev , vol.7 , pp. 454-467
    • Miller, M.W.1
  • 17
    • 0029040210 scopus 로고
    • Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
    • Naggert JK, et al. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet 1995;10:135-42.
    • (1995) Nat Genet , vol.10 , pp. 135-142
    • Naggert, J.K.1
  • 18
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar D, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997;88:131-41.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1
  • 19
    • 0032863468 scopus 로고    scopus 로고
    • Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    • Yaswen L, Diehl N, Brennan MB, et al. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 1999;5:1066-70.
    • (1999) Nat Med , vol.5 , pp. 1066-1070
    • Yaswen, L.1    Diehl, N.2    Brennan, M.B.3
  • 20
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997;278:135-8.
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1
  • 21
    • 0141564582 scopus 로고    scopus 로고
    • Melanocortin-4 receptor gene: Case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity
    • Hinney A, et al. Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. J Clin Endocrinol Metab 2003;88:4258-67.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4258-4267
    • Hinney, A.1
  • 22
    • 0037449172 scopus 로고    scopus 로고
    • Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: Identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5
    • Giesen K, Plum L, Kluge R, et al. Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5. Biochem Biophys Res Commun 2003;304:812-7.
    • (2003) Biochem Biophys Res Commun , vol.304 , pp. 812-817
    • Giesen, K.1    Plum, L.2    Kluge, R.3
  • 23
    • 0034015394 scopus 로고    scopus 로고
    • A metabolic syndrome of hypertension, hyperinsulinaemia and hypercholesterolaemia in the New Zealand obese mouse
    • Ortlepp JR, et al. A metabolic syndrome of hypertension, hyperinsulinaemia and hypercholesterolaemia in the New Zealand obese mouse. Eur J Clin Invest 2000;30:195-202.
    • (2000) Eur J Clin Invest , vol.30 , pp. 195-202
    • Ortlepp, J.R.1
  • 24
    • 20544471519 scopus 로고    scopus 로고
    • The human obesity gene map: The 2004 update
    • Perusse L, et al. The human obesity gene map: the 2004 update. Obes Res 2005;13:381-490.
    • (2005) Obes Res , vol.13 , pp. 381-490
    • Perusse, L.1
  • 25
    • 3042621978 scopus 로고    scopus 로고
    • The human obesity gene map: The 2003 update
    • Snyder EE, et al. The human obesity gene map: the 2003 update. Obes Res 2004;12:369-439.
    • (2004) Obes Res , vol.12 , pp. 369-439
    • Snyder, E.E.1
  • 26
    • 0033343736 scopus 로고    scopus 로고
    • Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
    • Hinney A, et al. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. J Clin Endocrinol Metab 1999;84:1483-6.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1483-1486
    • Hinney, A.1
  • 27
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity
    • Vaisse C, Clement K, Guy-Grand B, et al. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998;20:113-4.
    • (1998) Nat Genet , vol.20 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-Grand, B.3
  • 28
    • 0031668219 scopus 로고    scopus 로고
    • A frameshift mutation in MC4R associated with dominantly inherited human obesity
    • Yeo GS, et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 1998;20:111-2.
    • (1998) Nat Genet , vol.20 , pp. 111-112
    • Yeo, G.S.1
  • 29
    • 0030006024 scopus 로고    scopus 로고
    • A candidate gene for the mouse mutation tubby
    • Noben-Trauth K, Naggert JK, North MA, et al. A candidate gene for the mouse mutation tubby. Nature 1996;380:534-8.
    • (1996) Nature , vol.380 , pp. 534-538
    • Noben-Trauth, K.1    Naggert, J.K.2    North, M.A.3
  • 30
    • 15844372440 scopus 로고    scopus 로고
    • Identification and characterization of the mouse obesity gene tubby: A member of a novel gene family
    • Kleyn PW, et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 1996;85:281-90.
    • (1996) Cell , vol.85 , pp. 281-290
    • Kleyn, P.W.1
  • 31
    • 0029780748 scopus 로고    scopus 로고
    • Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus
    • Chen Y, Duhl DM, Barsh GS. Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus. Genetics 1996;144:265-77.
    • (1996) Genetics , vol.144 , pp. 265-277
    • Chen, Y.1    Duhl, D.M.2    Barsh, G.S.3
  • 32
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    • Clement K, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
    • (1998) Nature , vol.392 , pp. 398-401
    • Clement, K.1
  • 33
    • 0030949271 scopus 로고    scopus 로고
    • Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
    • Jackson RS, et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 1997;16:303-6.
    • (1997) Nat Genet , vol.16 , pp. 303-306
    • Jackson, R.S.1
  • 34
    • 2642512097 scopus 로고    scopus 로고
    • GAD2 on chromosome 10p12 is a candidate gene for human obesity
    • Boutin P, et al. GAD2 on chromosome 10p12 is a candidate gene for human obesity. PLoS Biol 2003;1:E68.
    • (2003) PLoS Biol , vol.1
    • Boutin, P.1
  • 35
    • 24944462326 scopus 로고    scopus 로고
    • Lack of support for the association between GAD2 polymorphisms and severe human obesity
    • Swarbrick MM, et al. Lack of support for the association between GAD2 polymorphisms and severe human obesity. PLoS Biol 2005;3:e315.
    • (2005) PLoS Biol , vol.3
    • Swarbrick, M.M.1
  • 36
    • 33645825830 scopus 로고    scopus 로고
    • A common genetic variant 10 kb upstream of INSIG2 is associated with adult and childhood obesity
    • Herbert A, et al. A common genetic variant 10 kb upstream of INSIG2 is associated with adult and childhood obesity. Science 2006:312:279-83.
    • (2006) Science , vol.312 , pp. 279-283
    • Herbert, A.1
  • 37
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi IS, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110:1093-103.
    • (2002) J Clin Invest , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1
  • 38
    • 22144457639 scopus 로고    scopus 로고
    • Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy
    • Williamson DA, et al. Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy. Appetite 2005;45:75-80.
    • (2005) Appetite , vol.45 , pp. 75-80
    • Williamson, D.A.1
  • 39
    • 18844435641 scopus 로고    scopus 로고
    • Effect of leptin replacement on brain structure in genetically leptin-deficient adults
    • Matochik JA, et al. Effect of leptin replacement on brain structure in genetically leptin-deficient adults. J Clin Endocrinol Metab 2005;90:2851-4.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2851-2854
    • Matochik, J.A.1
  • 40
    • 0035810771 scopus 로고    scopus 로고
    • Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor
    • Haskell-Luevano C, Monck EK. Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor. Regul Pept 2001;99:1-7.
    • (2001) Regul Pept , vol.99 , pp. 1-7
    • Haskell-Luevano, C.1    Monck, E.K.2
  • 41
    • 0035130843 scopus 로고    scopus 로고
    • AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor
    • Nijenhuis WA, Oosterom J, Adan RA. AgRP(83-132) acts as an inverse agonist on the human-melanocortin-4 receptor. Mol Endocrinol 2001;15:164-71.
    • (2001) Mol Endocrinol , vol.15 , pp. 164-171
    • Nijenhuis, W.A.1    Oosterom, J.2    Adan, R.A.3
  • 42
    • 17844372731 scopus 로고    scopus 로고
    • Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3
    • Reizes O, et al. Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3. Cell 2001;106:105-16.
    • (2001) Cell , vol.106 , pp. 105-116
    • Reizes, O.1
  • 43
    • 16544371717 scopus 로고    scopus 로고
    • Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22
    • Cai G, et al. Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. Am J Clin Nutr 2004;80:1410-4.
    • (2004) Am J Clin Nutr , vol.80 , pp. 1410-1414
    • Cai, G.1
  • 44
    • 0031017322 scopus 로고    scopus 로고
    • A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
    • Comuzzie AG, et al. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 1997;15:273-6.
    • (1997) Nat Genet , vol.15 , pp. 273-276
    • Comuzzie, A.G.1
  • 45
    • 0033305324 scopus 로고    scopus 로고
    • Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene, POMC
    • Hixson JE, et al. Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene, POMC. J Clin Endocrinol Metab 1999;84:3187-91.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3187-3191
    • Hixson, J.E.1
  • 46
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H, et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998;19:155-7.
    • (1998) Nat Genet , vol.19 , pp. 155-157
    • Krude, H.1
  • 47
    • 0242320429 scopus 로고    scopus 로고
    • Obesity due to proopiomelanocortin deficiency: Three new cases and treatment trials with thyroid hormone and ACTH4-10
    • Krude H, et al. Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab 2003;88:4633-40.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4633-4640
    • Krude, H.1
  • 48
    • 0037101841 scopus 로고    scopus 로고
    • A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
    • Challis BG, et al. A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Hum Mol Genet 2002;11:1997-2004.
    • (2002) Hum Mol Genet , vol.11 , pp. 1997-2004
    • Challis, B.G.1
  • 49
    • 20544469112 scopus 로고    scopus 로고
    • Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity
    • Tao YX. Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Mol Cell Endocrinol 2005;239:1-14.
    • (2005) Mol Cell Endocrinol , vol.239 , pp. 1-14
    • Tao, Y.X.1
  • 50
    • 6344260502 scopus 로고    scopus 로고
    • Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index
    • Dempfle A, et al. Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index. J Med Genet 2004;41:795-800.
    • (2004) J Med Genet , vol.41 , pp. 795-800
    • Dempfle, A.1
  • 52
    • 12144289073 scopus 로고    scopus 로고
    • Melanocortin-4 receptor gene variant I103 is negatively associated with obesity
    • Geller F, et al. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet 2004;74:572-81.
    • (2004) Am J Hum Genet , vol.74 , pp. 572-581
    • Geller, F.1
  • 53
    • 28544447162 scopus 로고    scopus 로고
    • Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys
    • Heid IM, et al. Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys. J Med Genet 2005;42:e21.
    • (2005) J Med Genet , vol.42
    • Heid, I.M.1
  • 54
    • 32544452700 scopus 로고    scopus 로고
    • The 103I variant of the melanocortin 4 receptor (MC4R) is associated with low serum triglyceride levels
    • Bronner G, et al.The 103I variant of the melanocortin 4 receptor (MC4R) is associated with low serum triglyceride levels. J Clin Endocrinol Metab 2006;91:535-8.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 535-538
    • Bronner, G.1
  • 55
    • 0034716472 scopus 로고    scopus 로고
    • Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations
    • Tunstall-Pedoe H, et al. Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations. Lancet 2000;355:688-700.
    • (2000) Lancet , vol.355 , pp. 688-700
    • Tunstall-Pedoe, H.1
  • 56
    • 21544467275 scopus 로고    scopus 로고
    • Pathophysiology of coronary artery disease
    • Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation 2005;111:3481-8.
    • (2005) Circulation , vol.111 , pp. 3481-3488
    • Libby, P.1    Theroux, P.2
  • 57
    • 0032440577 scopus 로고    scopus 로고
    • Molecular genetics of coronary artery disease: Measuring the phenotype
    • Lond
    • Samani NJ. Molecular genetics of coronary artery disease: measuring the phenotype. Clin Sci (Lond) 1998;95:645-6.
    • (1998) Clin Sci , vol.95 , pp. 645-646
    • Samani, N.J.1
  • 58
    • 20044382611 scopus 로고    scopus 로고
    • Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction
    • Fischer M, et al. Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation 2005;111:855-62.
    • (2005) Circulation , vol.111 , pp. 855-862
    • Fischer, M.1
  • 59
    • 0141819194 scopus 로고    scopus 로고
    • The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
    • Gretarsdottir S, et al. The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet 2003;35:131-8.
    • (2003) Nat Genet , vol.35 , pp. 131-138
    • Gretarsdottir, S.1
  • 60
    • 0032719544 scopus 로고    scopus 로고
    • The joint impact of family history of myocardial infarction and other risk factors on 12-year coronary heart disease mortality
    • Boer JM, Feskens EJ, Verschuren WM, et al. The joint impact of family history of myocardial infarction and other risk factors on 12-year coronary heart disease mortality. Epidemiology 1999;10:767-70.
    • (1999) Epidemiology , vol.10 , pp. 767-770
    • Boer, J.M.1    Feskens, E.J.2    Verschuren, W.M.3
  • 61
    • 0141924146 scopus 로고    scopus 로고
    • Family history is a coronary heart disease risk factor in the Second Northwick Park Heart Study
    • Hawe E, Talmud PJ, Miller GJ, et al. Family history is a coronary heart disease risk factor in the Second Northwick Park Heart Study. Ann Hum Genet 2003;67:97-106.
    • (2003) Ann Hum Genet , vol.67 , pp. 97-106
    • Hawe, E.1    Talmud, P.J.2    Miller, G.J.3
  • 62
    • 0028330005 scopus 로고
    • Genetic susceptibility to death from coronary heart disease in a study of twins
    • Marenberg ME, Risch N, Berkman LF, et al. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 1994;330:1041-6.
    • (1994) N Engl J Med , vol.330 , pp. 1041-1046
    • Marenberg, M.E.1    Risch, N.2    Berkman, L.F.3
  • 63
    • 0028844204 scopus 로고
    • Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy
    • Watkins H, et al. Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy. Nat Genet 1995;11:434-7.
    • (1995) Nat Genet , vol.11 , pp. 434-437
    • Watkins, H.1
  • 64
    • 24644467759 scopus 로고    scopus 로고
    • Mutations in NOTCH1 cause aortic valve disease
    • Garg V, et al. Mutations in NOTCH1 cause aortic valve disease. Nature 2005;437:270-4.
    • (2005) Nature , vol.437 , pp. 270-274
    • Garg, V.1
  • 65
    • 4644346837 scopus 로고    scopus 로고
    • Prenatal molecular diagnosis in hypertrophic cardiomyopathy: Report of the first case
    • Charron P, et al. Prenatal molecular diagnosis in hypertrophic cardiomyopathy: report of the first case. Prenat Diagn 2004;24:701-3.
    • (2004) Prenat Diagn , vol.24 , pp. 701-703
    • Charron, P.1
  • 66
    • 0026675062 scopus 로고
    • Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
    • Cambien F, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992;359:641-4.
    • (1992) Nature , vol.359 , pp. 641-644
    • Cambien, F.1
  • 67
    • 0037274826 scopus 로고    scopus 로고
    • Apolipoprotein E polymorphism and atherosclerosis
    • Kolovou G, Daskalova D, Mikhailidis DP. Apolipoprotein E polymorphism and atherosclerosis. Angiology 2003;54:59-71.
    • (2003) Angiology , vol.54 , pp. 59-71
    • Kolovou, G.1    Daskalova, D.2    Mikhailidis, D.P.3
  • 68
    • 0035571606 scopus 로고    scopus 로고
    • Immune mechanisms in atherosclerosis
    • Hansson GK. Immune mechanisms in atherosclerosis. Arterioscler Thromb Vasc Biol 2001;21:1876-90.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1876-1890
    • Hansson, G.K.1
  • 69
    • 28444457805 scopus 로고    scopus 로고
    • Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men
    • Chiappelli M, et al. Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. Int J Immunogenet 2005;32:349-53.
    • (2005) Int J Immunogenet , vol.32 , pp. 349-353
    • Chiappelli, M.1
  • 70
    • 33745168580 scopus 로고    scopus 로고
    • Association of TNF-[alpha] serum levels and TNFA promoter polymorphisms with risk of myocardial infarction
    • in press
    • Bennet AM, et al. Association of TNF-[alpha] serum levels and TNFA promoter polymorphisms with risk of myocardial infarction. Atherosclerosis 2006:in press.
    • (2006) Atherosclerosis
    • Bennet, A.M.1
  • 71
    • 21944444926 scopus 로고    scopus 로고
    • Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction
    • Holloway JW, Yang IA, Ye S. Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction. Pharmacogenet Genom 2005;15:15-21.
    • (2005) Pharmacogenet Genom , vol.15 , pp. 15-21
    • Holloway, J.W.1    Yang, I.A.2    Ye, S.3
  • 72
    • 0034161456 scopus 로고    scopus 로고
    • Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease
    • Lane DA, Grant PJ. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 2000;95:1517-32.
    • (2000) Blood , vol.95 , pp. 1517-1532
    • Lane, D.A.1    Grant, P.J.2
  • 73
    • 0742288585 scopus 로고    scopus 로고
    • The complex interplay among factors that influence allelic association
    • Zondervan KT, Cardon LR. The complex interplay among factors that influence allelic association. Nat Rev Genet 2004;5:89-100.
    • (2004) Nat Rev Genet , vol.5 , pp. 89-100
    • Zondervan, K.T.1    Cardon, L.R.2
  • 74
    • 23944469845 scopus 로고    scopus 로고
    • Recent developments in genomewide association scans: A workshop summary and review
    • Thomas DC, Haile RW, Duggan D. Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet 2005;77:337-45.
    • (2005) Am J Hum Genet , vol.77 , pp. 337-345
    • Thomas, D.C.1    Haile, R.W.2    Duggan, D.3
  • 75
    • 18744407845 scopus 로고    scopus 로고
    • Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction
    • Ozaki K, et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 2002;32:650-4.
    • (2002) Nat Genet , vol.32 , pp. 650-654
    • Ozaki, K.1
  • 76
    • 3843138430 scopus 로고    scopus 로고
    • Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese
    • Yamada A, et al. Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese. J Mol Med 2004;82:477-83.
    • (2004) J Mol Med , vol.82 , pp. 477-483
    • Yamada, A.1
  • 77
    • 0142027222 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha, lymphotoxin-alpha, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting
    • Koch W, Tiroch K, Beckerath N von, et al. Tumor necrosis factor-alpha, lymphotoxin-alpha, and interleukin-10 gene polymorphisms and restenosis after coronary artery stenting. Cytokine 2003;24:161-71.
    • (2003) Cytokine , vol.24 , pp. 161-171
    • Koch, W.1    Tiroch, K.2    Von Beckerath, N.3
  • 78
    • 4644324638 scopus 로고    scopus 로고
    • A trio family study showing association of the lymphotoxin-alpha N26 (804A) allele with coronary artery disease
    • Procardis Consortium. A trio family study showing association of the lymphotoxin-alpha N26 (804A) allele with coronary artery disease. Eur J Hum Genet 2004;12:770-4.
    • (2004) Eur J Hum Genet , vol.12 , pp. 770-774
  • 79
    • 0033658950 scopus 로고    scopus 로고
    • Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland
    • Pajukanta P, et al. Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. Am J Hum Genet 2000;67:1481-93.
    • (2000) Am J Hum Genet , vol.67 , pp. 1481-1493
    • Pajukanta, P.1
  • 80
    • 18244398717 scopus 로고    scopus 로고
    • A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27
    • Francke S, et al. A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum Mol Genet 2001;10:2751-65.
    • (2001) Hum Mol Genet , vol.10 , pp. 2751-2765
    • Francke, S.1
  • 81
    • 18544372620 scopus 로고    scopus 로고
    • A comprehensive linkage analysis for myocardial infarction and its related risk factors
    • Broeckel U, et al. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet 2002;30:210-4.
    • (2002) Nat Genet , vol.30 , pp. 210-214
    • Broeckel, U.1
  • 82
    • 0036094165 scopus 로고    scopus 로고
    • Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2
    • Harrap SB, et al. Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2. Arterioscler Thromb Vasc Biol 2002;22:874-8.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 874-878
    • Harrap, S.B.1
  • 83
    • 10744233196 scopus 로고    scopus 로고
    • Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis
    • Wang Q, et al. Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet 2004;74:262-71.
    • (2004) Am J Hum Genet , vol.74 , pp. 262-271
    • Wang, Q.1
  • 84
    • 4143098058 scopus 로고    scopus 로고
    • A genomewide scan for early-onset coronary artery disease in 438 families: The GENECARD study
    • Hauser ER, et al. A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD study. Am J Hum Genet 2004;75:436-47.
    • (2004) Am J Hum Genet , vol.75 , pp. 436-447
    • Hauser, E.R.1
  • 85
    • 10744220794 scopus 로고    scopus 로고
    • The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
    • Helgadottir A, et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 2004;36:233-9.
    • (2004) Nat Genet , vol.36 , pp. 233-239
    • Helgadottir, A.1
  • 86
    • 33644621593 scopus 로고    scopus 로고
    • ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance
    • Lond
    • Kaaman M, et al. ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. Int J Obes (Lond) 2005;30:447-52.
    • (2005) Int J Obes , vol.30 , pp. 447-452
    • Kaaman, M.1
  • 87
    • 0344827206 scopus 로고    scopus 로고
    • Mutation of MEF2A in an inherited disorder with features of coronary artery disease
    • Wang L, Fan C, Topol SE, et al. Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science 2003;302:1578-81.
    • (2003) Science , vol.302 , pp. 1578-1581
    • Wang, L.1    Fan, C.2    Topol, S.E.3
  • 88
    • 32944473313 scopus 로고    scopus 로고
    • The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction
    • Gonzalez P, et al. The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction. J Med Genet 2005;43:167-9.
    • (2005) J Med Genet , vol.43 , pp. 167-169
    • Gonzalez, P.1
  • 89
    • 16844368100 scopus 로고    scopus 로고
    • Lack of MEF2A mutations in coronary artery disease
    • Weng L, et al. Lack of MEF2A mutations in coronary artery disease. J Clin Invest 2005;115:1016-20.
    • (2005) J Clin Invest , vol.115 , pp. 1016-1020
    • Weng, L.1
  • 90
    • 11044220307 scopus 로고    scopus 로고
    • Transcription factor MEF2A mutations in patients with coronary artery disease
    • Bhagavatula MR, et al. Transcription factor MEF2A mutations in patients with coronary artery disease. Hum Mol Genet 2004;13:3181-8.
    • (2004) Hum Mol Genet , vol.13 , pp. 3181-3188
    • Bhagavatula, M.R.1
  • 91
    • 0034098728 scopus 로고    scopus 로고
    • New target regions for human hypertension via comparative genomics
    • Stoll M, et al. New target regions for human hypertension via comparative genomics. Genome Res 2000;10:473-82.
    • (2000) Genome Res , vol.10 , pp. 473-482
    • Stoll, M.1
  • 92
    • 4143124261 scopus 로고    scopus 로고
    • Unraveling the genetics of chronic kidney disease using animal models
    • Korstanje R, DiPetrillo K. Unraveling the genetics of chronic kidney disease using animal models. Am J Physiol Renal Physiol 2004;287:F347-52.
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Korstanje, R.1    DiPetrillo, K.2
  • 93
    • 0022003324 scopus 로고
    • Variation in susceptibility to atherosclerosis among inbred strains of mice
    • Paigen B, Morrow A, Brandon C, et al. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 1985;57:65-73.
    • (1985) Atherosclerosis , vol.57 , pp. 65-73
    • Paigen, B.1    Morrow, A.2    Brandon, C.3
  • 94
    • 20544467972 scopus 로고    scopus 로고
    • Identifying novel genes for atherosclerosis through mouse-human comparative genetics
    • Wang X, Ishimori N, Korstanje R, et al. Identifying novel genes for atherosclerosis through mouse-human comparative genetics. Am J Hum Genet 2005;77:1-15.
    • (2005) Am J Hum Genet , vol.77 , pp. 1-15
    • Wang, X.1    Ishimori, N.2    Korstanje, R.3
  • 95
    • 4644219642 scopus 로고    scopus 로고
    • Haplotype analysis in multiple crosses to identify a QTL gene
    • Wang X, Korstanje R, Higgins D, et al. Haplotype analysis in multiple crosses to identify a QTL gene. Genome Res 2004;14:1767-72.
    • (2004) Genome Res , vol.14 , pp. 1767-1772
    • Wang, X.1    Korstanje, R.2    Higgins, D.3
  • 96
    • 0023551561 scopus 로고
    • Genetic analysis of strains C57BL/6J and BALB/cJ for Ath-1, a gene determining atherosclerosis susceptibility in mice
    • Paigen B, Mitchell D, Holmes PA, et al. Genetic analysis of strains C57BL/6J and BALB/cJ for Ath-1, a gene determining atherosclerosis susceptibility in mice. Biochem Genet 1987;25:881-92.
    • (1987) Biochem Genet , vol.25 , pp. 881-892
    • Paigen, B.1    Mitchell, D.2    Holmes, P.A.3
  • 97
    • 0023391441 scopus 로고
    • Genetic analysis of murine strains C57BL/6J and C3H/HeJ to confirm the map position of Ath-1, a gene determining atherosclerosis susceptibility
    • Paigen B, Albee D, Holmes PA, et al. Genetic analysis of murine strains C57BL/6J and C3H/HeJ to confirm the map position of Ath-1, a gene determining atherosclerosis susceptibility. Biochem. Genet. 1987;25:501-11.
    • (1987) Biochem. Genet. , vol.25 , pp. 501-511
    • Paigen, B.1    Albee, D.2    Holmes, P.A.3
  • 98
    • 0342855957 scopus 로고
    • Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice
    • U S A
    • Paigen B, et al. Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Proc Natl Acad Sci U S A 1987;84:3763-7.
    • (1987) Proc Natl Acad Sci , vol.84 , pp. 3763-3767
    • Paigen, B.1
  • 99
    • 0036802653 scopus 로고    scopus 로고
    • Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on chromosome 1
    • Phelan SA, Beier DR, Higgins DC, et al. Confirmation and high resolution mapping of an atherosclerosis susceptibility gene in mice on chromosome 1. Mamm Genome 2002;13:548-53.
    • (2002) Mamm Genome , vol.13 , pp. 548-553
    • Phelan, S.A.1    Beier, D.R.2    Higgins, D.C.3
  • 100
    • 20144386616 scopus 로고    scopus 로고
    • Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility
    • Wang X, et al. Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet 2005;37:365-72.
    • (2005) Nat Genet , vol.37 , pp. 365-372
    • Wang, X.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.