Mutation of MEF2A in an Inherited Disorder with Features of Coronary Artery Disease

Science

Volumn 302, Issue 5650, 2003, Pages 1578-1581

  Wang, Lejin ^a,b   Fan, Chun ^a,b   Topol, Sarah E ^a   Topol, Eric J ^a,b   Wang, Qing ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARDIOLOGY; GENES; PROTEINS;

CORONARY ARTERY DISEASE (CAD); PATHOGENESIS;

DISEASE CONTROL;

AMINO ACID; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2A; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG;

CARDIOVASCULAR DISEASE; GENETICS; MUTATION; PROTEIN;

ADULT; AGED; AMINO ACID ANALYSIS; ARTERY ENDOTHELIUM; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL NUCLEUS; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY DISEASE; GENE MUTATION; GENETIC ANALYSIS; GENETIC DISORDER; HEART INFARCTION; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; VASCULAR DISEASE;

AGED; AMINO ACID SEQUENCE; ANIMALS; ARTERIES; BASE SEQUENCE; CELL NUCLEUS; CHROMOSOMES, HUMAN, PAIR 15; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; DIMERIZATION; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION; GENES, DOMINANT; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); MADS DOMAIN PROTEINS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH; MYOCARDIAL INFARCTION; MYOGENIC REGULATORY FACTORS; PEDIGREE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; RISK FACTORS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0344827206     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088477     Document Type: Article

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19. We thank E. F. Plow and J. D. Smith for critical review of the manuscript; E. N. Olson for the MEF2A expression plasmids; C. Fersky, R. Cannata, R. Kadaba, L. Li, S. Archacki, G. Shen, S. Chen, X. Tian, A. Bakos, E. Zirzow, S. Rao, S. You, and other members of Wang laboratory for help and discussion; and the study participants for their enthusiasm and support for this study. Supported by the Cleveland Clinic Foundation Center for Cardiovascular Genetics funds, a Doris Duke Innovation in Clinical Research award (Q.W. and E.J.T.), and NIH grant nos. R01 HL65630 (Q.W.) and R01 HL66251 (Q.W.).