A metabolic syndrome of hypertension, hyperinsulinaemia and hypercholesterolaemia in the New Zealand obese mouse

European Journal of Clinical Investigation

Volumn 30, Issue 3, 2000, Pages 195-202

  Ortlepp, J R ^a   Kluge, R ^a   Giesen, K ^a   Plum, L ^a   Radke, P ^a   Hanrath, P ^a   Joost, H G ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Back cross; Hypercholesterolaemia; Hypertension; Insulin resistance; Metabolic syndrome; New Zealand obese mouse

Indexed keywords

CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HYPERCHOLESTEROLEMIA; HYPERINSULINEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; BODY WEIGHT; CHOLESTEROL; FEMALE; HYPERCHOLESTEROLEMIA; HYPERINSULINISM; HYPERTENSION; INSULIN; MALE; MICE; MICE, OBESE; SYNDROME;

EID: 0034015394     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2000.00611.x     Document Type: Article

References (37)

1. 1 Bielschowsky M, Bielschowsky F. A new strain of mice with hereditary obesity. Proc Univ Otago Med School 1953;31:29-31.
2. 2 Subrahmanyam K. Metabolism in the New Zealand strain of obese mice. Biochem J 1960;76:548-56.
3. 3 Crofford OB, Davis CK. Growth characteristics, glucose tolerance and insulin sensitivity of New Zealand Obese mice. Metabolism 1965;14:271-80.
4. 4 Herberg L, Coleman DL. Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 1977;26:59-98.
5. 5 Veroni MC, Proietto J, Larkins RG. Evolution of insulin resistance in New Zealand obese mice. Diabetes 1991;40:1480-7.
6. 6 Igel M, Becker W, Herberg L, Joost HG. Hyperleptinemia, leptin resistance and polymorphic leptin receptor in the New Zealand Obese (NZO) mouse. Endocrinology 1997;138:4234-9.
7. 7 Leiter EH, Reifsnyder PC, Flurkey K, Partke HJ, Junger E, Herberg L. NIDDM genes in mice. Deleterious synergism by both parental genomes contributes to diabetic thresholds. Diabetes 1998;47:1287-95.
8. 8 Mark AL, Correia M, Morgan DA, Shaffer RA, Haynes WG. Obesity induced hypertension: new concepts from the emerging biology of obesity. Hypertension 1999;33:537-41.
9. 9 Brands MW, Hall JE, Keen HL. Is insulin resistance linked to hypertension? Clin Exp Pharmacol Physiol 1998;25:70-6.
10. 10 Müller-Wieland D, Kotzka J, Knebel B, Krone W. Metabolic syndrome and hypertension: pathophysiology and molecular basis of insulin resistance. Basic Res Cardiol 1998;93(Suppl 2):131-4.
11. 11 Scherrer U, Sartori C. Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity and cardiovascular morbidity. Circulation 1997;96:4104-13.
12. 12 Cleland SJ, Petrie JR, Ueda S, Elliott HL, Connell JM. Insulin as a vascular hormone: implications for the pathophysiology of cardiovascular disease. Clin Exp Pharmacol Physiol 1998;25:175-84.
13. 13 Klöting I, Berg S, Kovac P, Voigt B, Vogt L, Schmidt S. Diabetes and hypertension in rodent models. Ann NY Acad Sci 1997;827:64-84.
14. 14 Mills E, Kuhn CM, Feinglos MN, Surwit R. Hypertension in C57BL/6J mouse model of non-insulin dependent diabetes mellitus. Am J Physiol 1993;264:R73-8.
15. 15 Paigen B. Genetics of responsiveness to high fat and high cholesterol diets in mice. Am J Clin Nutr 1995;62:458S-62S.
16. 16 Krege JH, Hodgin JB, Hagaman JR, Smithies O. A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension 1995;25:1111-5.
17. 17 Bielschowsky M, Goodall CM. Origin of inbred NZ mouse strains. Cancer Res 1970;30:834-6.
18. 18 Festing MFW. Inbred Strains in Biomedical Research. London: Macmillan Press; 1979.
19. 19 Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, et al. Identification of Cd36 (Fat) as an insulin resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nature Genet 1999;21:76-83.
20. 20 Baron AD. Hemodynamic actions of insulin. Am J Physiol 1994;267:E187-202.
21. 21 Vollenweider P, Randin D, Tappy L, Jequier E, Nicod P, Scherrer U. Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. J Clin Invest 1994;93:1265-71.
22. 22 Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 1994;94:1172-9.
23. 23 Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 1994;94:2511-5.
24. 24 Ueda S, Petrie JR, Elliott HL, Connell JM. The vasodilating effect of insulin is dependent on local glucose uptake: a double blind, placebo-controlled study. J Clin Endocrinol Metab 1998;83:2126-31.
25. 25 Abe H, Yamada N, Kamata K, Kuwaki T, Shimada M, Osuga J, et al. Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest 1998;101:1784-8.
26. 26 Stenbit AE, Tsao TS, Burcelin R, Geenen DL, Factor SM, Houseknecht K, et al. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Med 1997;3:1096-101.
27. 27 Leiter EH, Chapman HD, Falany CN. Synergism of obesity genes with hepatic steroid sulfotransferases to mediate diabetes in mice. Diabetes 1991;40:1360-3.
28. 28 Leiter EH, Chapman HD. Obesity-induced diabetes (diabesity) in C57BL/KsJ mice produces aberrant trans-regulation of sex steroid sulfotransferase genes. J Clin Invest 1994;93:2007-13.
29. 29 Haynes WG, Morgan DA, Walsh SA, Sivitz WI, Mark AL. Cardiovascular consequences of obesity: role of leptin. Clin Exp Pharmacol Physiol 1998;25:65-9.
30. 30 Suter PM, Locher R, Hasler E, Vetter W. Is there a role for the ob gene product leptin in essential hypertension? Am J Hypertension 1998;11:1305-11.
31. 31 Hirose H, Saito I, Tsujioka M, Mori M, Kawabe H, Saruta T. The obese gene product, leptin: possible role in obesity-related hypertension in adolescents. J Hypertension 1998;16:2007-12.
32. 32 Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptor mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997;100:270-8.
33. 33 Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998;31:409-14.
34. 34 Igel M, Kainulainen H, Brauers A, Becker W, Herberg L, Joost HG. Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents. Diabetologia 1996;39:758-65.
35. 35 Igel M, Becker W, Herberg L, Joost HG. Leptin and leptin receptor abnormalities in mouse strains with polygenic obesity. In: Blum WF, Kiess W, Rascher W, editors. Leptin - The Voice of Adipose Tissue. Leipzig: J.A. Barth-Verlag; 1997. p.43-9.
36. 36 Halaas JL, Boozer C, Blair-West J, Fidahusein N, Demon DA, Friedman JM. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997;94:8878-83.
37. 37 Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Häring HU. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate dependent pathways. Diabetologia 1997;40:1358-62.