Role of early cytokines, including alpha and beta interferons (IFN-α/β), in innate and adaptive immune responses to viral infections

Seminars in Immunology

Volumn 10, Issue 5, 1998, Pages 383-390

  Biron, Christine A ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

CD8 T cells; IFN; Innate immunity; NK cells; Viral infections

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CD8 ANTIGEN; CYTOKINE;

MACROPHAGE; NATURAL KILLER CELL; REVIEW; T LYMPHOCYTE; VIRUS IMMUNITY; VIRUS INFECTION;

EID: 0032191176     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1998.0138     Document Type: Article

References (76)

1. 1. Ahmed R, Biron CA (1998) Immunity to viruses, in the Fourth Edition of Fundamental Immunology (Paul WE, ed) in press. Raven Press, New York
2. 2. Vilcek J, Sen GC (1996) Interferons and other cytokines, in the Third Edition of Fundamental Virology (Fields BN, Knipe DM, Howley PM, eds) pp 341-365. Lippincott-Raven Publishers, New York
3. 3. Biron CA, Gazzinelli RT (1995) Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr Opin Immunol 7:485-496
4. 4. Romani L, Puccetti P, Bistoni F (1997) Interleukin-12 in infectious diseases. Clin Microbiol Rev 10:611-636
5. 5. Rivière Y, Bandu M-T (1977) Induction d'interféron par le virus de la chorioménigite lymphocytaire chez la souris. Ann Microbiol (Inst Pasteur) 128A:323-329
6. 6. Welsh RM (1978) Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice. I. Characterization of natural killer cell induction. J Exp Med 148:163-181
7. 7. Grundy (Chalmer) JE, Trapman J, Allan JE, Shellam GR, Melief CJM (1982) Evidence for a protective role of interferon in resistance to murine cytomegalovirus and its control by non-H-2-linked genes. Infect Immunol 37:143-150
8. 8. Orange JS, Biron CA (1996) Characterization of early IL-12, IFN-α/β, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. J Immunol 156:4746-4756
9. 9. Trgovcich J, Aronson JF, Johnston RE (1996) Fatal Sindbis virus infection of neonatal mice in the absence of encephalitis. Virology 224:73-83
10. 10. Biron CA, Pederson KF, Welsh RM (1987) Aberrant T cells in beige mutant mice. J Immunol 138:2050-2056
11. 11. Kasaian MT, Biron CA (1989) The activation of IL-2 transcription in L3T4 + and Lyt-2 + lymphocytes during virus infection in vivo. J Immunol 142:1287-1292
12. 12. Cousens LP, Orange JS, Biron CA (1995) Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection. J Immunol 155:5690-5699
13. 13. Murali-Krishna K, Altman JD, Suresh M, Sourdive DJ, Zajac AJ, Miller JD, Slansky J, Ahmed R (1998) Counting antigen specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177-187
14. + T cell interactions in IFN-γ and IL-4 responses to viral infections: requirements for IL-2. J Immunol 160:5007-5017
15. 15. Orange JS, Biron CA (1996) An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections. J Immunol 156:1138-1142
16. 16. Manetti R, Parronchi P, Giudizi MG, Piccinni MP, Maggi E, Trinchieri G, Romagnani S (1993) Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4 producing Th cells. J Exp Med 177:1199-1204
17. + T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming. Proc Natl Acad Sci USA 90:10188-10192
18. 18. Coutelier JP, Van Broeck J, Wolf SF (1995) Interleukin-12 gene expression after viral infection in the mouse. J Virol 69:1955-1958
19. 19. Kanangat S, Thomas J, Gangappa S, Babu JS, Rouse BT (1996) Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection. J Immunol 156:1110-1116
20. 20. Ruzek MC, Miller AH, Opal SM, Pearce BD, Biron CA (1997) Characterization of early cytokine responses and an interleukin (IL)-6-dependent pathway of endogenous glucocorticoid induction during murine cytomegalovirus infection. J Exp Med 185:1185-1192
21. 21. Schijns VECJ, Wierda CMH, van Hoeij M, Horzinek MC (1996) Exacerbated viral hepatitis in IFN-γ receptor-deficient mice is not suppressed by IL-12. J Immunol 157:815-821
22. 22. Cousens LP, Orange JS, Su HC, Biron CA (1997) Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc Natl Acad Sci USA 94:634-639
23. 23. Orange JS, Wolf SF, Biron CA (1994) Effects of IL-12 on the response and susceptibility to experimental viral infections. J Immunol 152:1253-1264
24. 24. Orange JS, Salazar-Mather TP, Opal SM, Spencer RL, Miller AH, McEwen BS, Biron CA (1995) Mechanism of interleukin 12-mediated toxicities during experimental viral infections: Role of tumor necrosis factor and glucocorticoids. J Exp Med 181:901-914
25. 25. Diefenbach A, Schindler H, Donhauser N, Lorenz E, Laskay T, MacMicking J, Röllinghoff M, Gresser I, Bogdan C (1998) Type 1 interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 8:77-87
26. 26. Gutierrez-Ramos JC, Bluethmann H (1997) Molecules and mechanisms operating in septic shock: lessons from knockout mice. Immunol Today 18:329-334
27. 27. McEwen BS, Biron CA, Brunson KW, Bulloch K, Chambers WH, Dhabhar FS, Goldfarb RH, Kitson RP, Miller AH, Spencer RL, Weiss JM (1997) The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Brain Res Rev 23:79-133
28. 28. Orange JS, Salazar-Mather TP, Opal SM, Biron CA (1997) Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection. J Virol 71:9248-9258
29. 29. Darnell JE (1997) STATS and gene regulation. Science 277:1630-1635
30. 30. Gilles PN, Fey G, Chisari FV (1992) Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice. J Virol 66:3955-3960
31. 31. Lucin P, Jonjic S, Messerle M, Polic B, Hengel H, Koszinowski UH (1994) Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. J Gen Virol 75:101-110
32. 32. Neuzil KM, Tang YW, Graham BS (1996) Protective role of TNF-alpha in respiratory syncytial virus infection in vitro and in vivo. Am J Med Sci 311:201-204
33. 33. Orange JS, Wang B, Terhorst C, Biron CA (1995) Requirement for natural killer (NK) cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J Exp Med 182:1045-1056
34. 34. Wong GHW, Goeddel DV (1986) Tumor necrosis factors alpha and beta inhibit virus replication and synergize with interferons. Nature 323:819-822
35. 35. MacMicking J, Xie QW, Nathan C (1997) Nitric oxide and macrophage function. Annu Rev Immunol 15:323-350
36. 36. Chan SH, Perussia B, Gupta JW, Kobayashi M, Pospisil M, Young HA, Wolf SF, Young D, Clark SC, Trinchieri G (1991) Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 173:869-879
37. 37. Komatsu T, Reiss CS (1997) IFN-γ is not required in the IL-12 response to vesicular stomatitis virus infection of the olfactory bulb. J Immunol 159:3444-3452
38. 38. Manetti R, Annuziato F, Tomasevic L, Gianno V, Parronchi P, Romagnani S, Maggi E (1995) Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12. Eur J Immunol 25:2656-2660
39. 39. Rogge L, Barberis-Maino, Biffi M, Passini N, Presky DH, Gubler U, Sinigaglia F (1997) Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J Exp Med 185:825-831
40. 40. Woodruff JF, Woodruff JJ (1970) Virus-induced alterations of lymphocyte tissues. I. Modification of the recirculating pool of small lymphocytes by Newcastle Disease Virus. Cell Immunol 1:333-354
41. 41. Gresser I, Guy-Grand D, Maury C, Maunoury MT (1981) Interferon induces peripheral lymphadenopathy in mice. J Immunol 127:1569-1575
42. 42. Dunnick JK, Galasso GJ (1980) Update on clinical trials with exogenous interferon. J Infect Dis 142:293-299
43. 43. Korngold R, Blank KJ, Murasko DM (1983) Effect of interferon on thoracic duct lymphocyte output: induction with either polyI:polyC or vaccinia virus. J Immunol 130:2236-2240
44. 44. Ishikawa R, Biron CA (1993) IFN induction and associated changes in splenic leukocyte distribution. J Immunol 150:3713-3727
45. 45. Salazar-Mather TP, Ishikawa R, Biron CA (1996) NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection. J Immunol 157:3054-3064
46. 46. Trinchieri G (1989) Biology of natural killer cells. Adv Immunol 47:187-376
47. 47. Biron CA (1997) Activation and function of natural killer cell responses during viral infections. Curr Opin Immunol 9:24-34
48. 48. Biron CA, Welsh RM (1982) Blastogenesis of natural killer cells during viral infection in vivo. J Immunol 129:2788-2795
49. 49. Biron CA, Sonnenfeld G, Welsh RM (1984) Interferon induces natural killer cell blastogenesis in vivo. J Leukocyte Biol 35:31-37
50. 50. Tough DF, Borrow P, Sprent J (1996) Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272:1947-1950
51. 51. Roake JA, Rao AS, Morris PJ, Larsen CP, Hankins DF, Austyn JM (1995) Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med 181:2237-2247
52. 52. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245-252
53. 53. Trinchieri G, Santoli D, Koprowski H (1978) Spontaneous cell-mediated cytotoxicity in humans: role of interferon and immunoglobulins. J Immunol 120:1849-1855
54. 54. Bukowski JF, Woda BA, Habu S, Okumura K, Welsh RM (1983) Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J Immunol 131:1531-1538
55. 55. Habu S, Akamatsu K, Tamaoki N, Okumura K (1984) In vivo significance of NK cells on resistance against virus (HSV-1) infections in mice. J Immunol 133:2743-2747
56. 56. Biron CA, Byron KS, Sullivan JL (1989) Severe herpesvirus infections in an adolescent without natural killer cells. New Eng J Med 320:1731-1735
57. 57. Kägi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen KJ, Podack ER, Zinkernagel RM, Hengartner H (1994) Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31-37
58. 58. Tay CH, Welsh RM (1997) Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells. J Virol 71:267-275
59. 59. Kobayashi M, Fitz L, Ryan M, Hewik RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170:827-845
60. 60. Salazar-Mather, TP, Orange JS, Biron CA (1998) Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIP-1 α)-dependent pathways. J Exp Med 187:1-14
61. 61. Heise MT, Virgin IV HW (1995) The T cell independent role of gamma interferon and tumor necrosis factor alpha in macrophage activation during murine cytomegalovirus and herpes simplex virus infections. J Virol 69:904-909
62. 62. Karupiah G, Xie QW, Buller RM, Nathan C, Duarte C, MacMicking JD (1993) Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science 261:1445-1448
63. 63. Bi Z, Reiss CS (1995) Inhibition of vesicular stomatitis virus infection by nitric oxide. J Virol 69:2208-2213
64. 64. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM (1989) Reciprocal expression of interferon-γ or interleukin 4 during the resolution of progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med 169:59-72
65. 65. Szabo SJ, Dighe AS, Gubler U, Murphy KM (1997) Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 185:817-824
66. 66. Gollob JA, Kawasaki H, Ritz J (1997) Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur J Immunol 27:647-652
67. 67. Graziosi C, Pantaleo G, Gantt KR, Fortin JP, Demarest JF, Cohen OJ, Sekaly RP, Fauci AS (1994) Lack of evidence for the dichotomy of TH1 and TH2 predominance in HW-infected individuals. Science 265:248-252
68. 68. Mo XY, Sarawar SR, Doherty PC (1995) Induction of cytokines in mice with parainfluenza pneumonia. J Virol 69:1288-1291
69. 69. Maggi E, Mazzetti M, Ravina A, Annunziato F, De Carli M, Piccinni MP, Manetti R, Carbonari M, Pesce AM, Del Prete G, Romagnani S (1994) Ability of HIV to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science 265:244-248
70. + T cells from human immunodeficiency virus-infected individuals. Blood 89:3672-3681
71. 71. Romagnani S, Del-Prete G, Manetti R, Ravina A, Annunziato F, De-Carli M, Mazzetti M, Piccinni MP, D'Elios MM, Parronchi P et al (1994) Role of TH1/TH2 cytokines in HIV infection. Immunol Rev 140:73-92
72. 72. Graham MB, Dalton DK, Giltinan D, Braciale VL, Stewart TA, Braciale TJ (1993) Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. J Exp Med 178:1725-1732
73. 73. Huang S, Hendriks W, Althage A, Hemmi S, Bluethmann H, Kamijo R, Vilcek J, Zinkernagel RM, Aguet M (1993) Immune response in mice that lack the interferon-γ receptor. Science 259:1742-1745
74. 74. van den Broek MF, Müller U, Huang S, Aguet M, Zinkernagel RM (1995) Antiviral defense in mice lacking both alpha/beta, and gamma interferon receptors. J Virol 69:4792-4796
75. + T cells. J Exp Med 178:1655-1663
76. 76. Lindahl P, Gresser I, Leary P, Tovey M (1976) Interferon treatment of mice. Enhanced expression of histocompatibility antigens on lymphoid cells. Proc Natl Acad Sci USA 73:1284-1287