Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 161, Issue 9, 1998, Pages 5097-5104

  Constantinescu, Cris S ^a,c   Wysocka, Maria ^b   Hilliard, Brendan ^a   Ventura, Elvira S ^a   Lavi, Ehud ^a   Trinchieri, Giorgio ^b   Rostami, Abdolmohamad ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; MYELIN BASIC PROTEIN; STAPHYLOCOCCUS ENTEROTOXIN; SUPERANTIGEN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; CELL STIMULATION; COMPLEX FORMATION; DRUG RECEPTOR BINDING; GENE FREQUENCY; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; AUTOIMMUNE DISEASES; BRAIN; CYTOKINES; DEMYELINATING DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENTEROTOXINS; FEMALE; GUINEA PIGS; IMMUNIZATION; INFLAMMATION; INTERLEUKIN-12; MALE; MICE; MOLECULAR MIMICRY; MYELIN BASIC PROTEINS; RATS; RECURRENCE; SEVERITY OF ILLNESS INDEX; SPINAL CORD; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS; TH1 CELLS;

EID: 0032211092     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Zamvil, S. S., and L. Steinman. 1990. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8:579.
2. Marrack, P., and J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science 248:705.
3. Brocke, S., A. Gaur, C. Piercy, A. Gautam, K. Gijbels, C. G. Fathman, and L. Steinman. 1993. Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature 365:642.
4. Schiffenbauer, J., H. M. Johnson, E. J. Butfiloski, L. Wegrzyn, and J. M. Soos. 1993. Staphylococcal enterotoxins can reactivate experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA 90:8543.
5. Matthews, W. B., A. Compston, I. V. Allen, and C. N. Martyn. 1991. McAlpine's Multiple Sclerosis. Edinburgh, Churchill Livingstone.
6. Fritz, R. B., J. C.-H. Chou, and D. E. McFarlin. 1983. Relapsing murine experimental allergic encephalomyelitis induced by myelin basic protein. J. Immunol. 130:1024.
7. Miethke, T., C. Wahl, K. Heeg, B. Echtenacher, P. H. Krammer, and H. Wagner. 1992. T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J. Exp. Med. 175: 191.
8. Mono, T., R. Geha, and T. Chatila. 1994. Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. Eur. J. Immunol. 24:651.
9. Mourad, W., K. Mehindate, T. J. Schall, and S. R. McColl. 1992. Engagement of major histocompatibility complex class II molecules by superantigen induces inflammatory cytokine gene expression in human fibroblast-like synoviocytes. J. Exp. Med. 175:613.
10. Pontzer, C. H., N. D. Griggs, and H. M. Johnson. 1993. Agonist properties of a microbial superantigen peptide. Biochem. Biophys. Res. Commun. 193:1191.
11. Hauschildt, S., W. Bessler, and P. Scheipers. 1993. Engagement of major histocompatibility complex class II molecules leads to nitrite production in bone marrow-derived macrophages. Eur. J. Immunol. 23:2988.
12. Schmitz, J., and A. Radbruch. 1992. Distinct antigen presenting cell-derived signals induce Th cell proliferation and expression of effector cytokines. Int. Immunol. 4:43.
13. + T cells. Eur. J. Immunol. 23:523.
14. Nagelkerken, L., K. J. Gollob, M. Tielemans, and R. L. Coffman. 1993. Role of transforming growth factor-β in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B. Eur. J. Immunol. 23:2301.
15. Krakauer, T. 1994. Costimulatory receptors for the superantigen staphylococcal enterotoxin B on human vascular endothelial cells and T cells. J. Leukocyte Biol. 56:458.
16. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J. Exp. Med. 170:827.
17. Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y. E. Pan, P. M. Quinn, A. G. Wolitzky, P. C. Familletti, D. L. Stremlo, T. Triutt, R. Chizzonite, and M. K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87:6808.
18. Scott, P. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260:496.
19. Trinchieri, G. 1993. Interleukin-12 and its role in the generation of Th1 cells. Immunol. Today 14:335.
20. Leonard, J. P., K. E. Waldburger, and S. J. Goldman. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181:381.
21. Waldburger, K. E., R. C. Hastings, R. G. Schaub, S. J. Goldman, and J. P. Leonard. 1996. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Am. J. Pathol. 148:375.
22. Smith, T., A. K. Hewson, C. I. Kingsley, J. P. Leonard, and M. L. Cuzner. 1997. Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat. Am. J. Pathol. 150:1909.
23. Leung, D. Y. M., M. Gately, A. Trumble, B. Fergusson-Darnell, P. M. Schlievert, and L. J. Picker. 1995. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J. Exp. Med. 181:747.
24. Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler. 1996. Regulation of murine macrophage IL-12 production: activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol. 156:1196.
25. Sriskandan, S., T. J. Evans, and J. Cohen. 1996. Bacterial superantigen-induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-γ. J. Immunol. 156:2430.
26. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste-Amezaga, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, et al. 1992. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
27. Segal, B. M., D. M. Klinman, E. M. Shevach. 1997. Microbial products induce autoimmune disease by an IL-12-dependent pathway. J. Immunol. 158:5087.
28. + helper/killer T cell phenomenon: selective induction of Th1 helper/killer cells and application to tumor immunotherapy. J. Immunol. 154:1777.
29. Deibler, G. E., R. E. Martenson, and M. W. Kies. 1972. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep. Biochem. 2:139.
30. Wysocka, M., M. Kubin, L. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672.
31. + T cells. Microb. Pathol. 18:211.
32. Miethke, T., C. Wahl, K. Heeg, and H. Wagner. 1995. Superantigens: the paradox of T-cell activation versus inactivation. Int. Arch. Allergy Immunol. 106:3.
33. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
34. Tripp, C. S., S. F. Wolff, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor are costimulators of Interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
35. Trembleau, S., T. Germann, and M. K. Gately. 1995. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol. Today 16:383.
36. Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533.
37. Tripp, C. S., O. Kanagawa, and E. R. Unanue. 1995. Secondary response to Listeria infection requires IFN-γ but is independent of IL-12. J. Immunol. 155: 3427.
38. Neurath, M. F., I. Fuss, B. L. Kelsall. E. Stüber, and W. Strober. 1995. Antibodies to interleukin-12 abrogate established experimental colitis in mice. J. Exp. Med. 182:1281.
39. Joosten, L. A. B., E. Lubberts, M. M. A. Hellsen, and W. B. van den Berg. 1997. Dual role of IL-12 in early and late stages of murine collagen type II arthritis. J. Immunol. 159:4092.
40. Seder, R. A., B. Kelsall, and D. Jankovic. 1996. Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease. J. Immunol. 157:2745.
41. Peritt, D., M. Aste-Amezaga, F. Gerosa, C. Paganin, and G. Trinchieri. 1996. Interleukin-10 induction by IL-12: a possible modulatory mechanism? Ann. NY Acad. Sci. 795:387.
42. Winghagen, A., D. E. Anderson, A. Carrizosa, R. E. Williams, and D.A. Hafler. 1997. IL-12 induces human T cells secreting IL-10 with IFN-γ. J. Immunol. 157:1127.
43. Kennedy, M.K., D. S. Torrance, K. S. Picha, and K. M. Mohler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496.
44. Rott, O., B. Fleisher, and E. Cash. 1994. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 24:1434.
45. Cannella, B., Y. L. Gao, C. Brosnan, C. S. Raine. 1996. IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45:735.
46. Crisi, G. M., L. Santambrogio, G. M. Hochwald, S. R. Smith, J. A. Carlino, and G. J. Thorbecke, 1995. Staphylococcus enterotoxin B and tumor-necrosis factor-α-induced relapses of experimental allergic encephalomyelitis: protection by transforming growth factor-β and interleukin-10. Eur. J. Immunol. 25:3035.
47. Segal, B. M., B. K. Dwyer, and E. M. Schevach. 1998. An Interleukin (IL)-10/ IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187:537.
48. Lehmann, P. V., E. E. Sercarz, T. Forsthuber. C. M. Dayan, and G. Gammon. 1993. Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today 14:203.
49. McRae, B. L., C. L. Vanderlugt, M. C. Dal Canto, and S. D. Miller. 1995. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J. Exp. Med. 182:75.
50. Yu, M., J. M. Johnson, and V. K. Tuohy. 1996. Generation of autonomously pathogenic neo-autoreactive Th1 cells during the development of the determinant spreading cascade in murine autoimmune encephalomyelitis. J. Neurosci. Res. 45:463.
51. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211.
52. Murphy, E., G. Terres, S. Macatonia, C.-S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin-12 cooperate for proliferation and interferon-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223.
53. Miller, S. D., C. L. Vanderlugt, D. J. Lenschow, J. G. Pope, N. J. Karandikar, M. C. Dal Canto, and J. A. Bluestone. 1995. Blockade of CD28/B7 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3:739.
54. Perrin, P. J., D. Scott, L. Quigley, P. S. Albert, O. Feder, G. S. Gray, R. Abe, C. H. June, and M. K. Racke. 1995. Role of B7:CD28/CTLA4 in the induction of chronic relapsing experimental allergic encephalomyelitis. J. Immunol. 154: 1481.
55. Miethke, T., C. Wahl, D. Regele, H. Gaus, K. Heeg, and H. Wagner. 1993. Superantigen-mediated shock: a cytokine release syndrome. Immunobiology 189: 270.
56. Ogawa, M., T. Tsutsui, J.-P. Zou, R. Wijesuriya, W.-G. Yu, S. Herrmann, T. Kubo, H. Fujiwara, and T. Harnaoka. 1997. Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin-12. Cancer Res. 57:2216.
57. + T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57.
58. Marth, T., W. Strober, and B. L. Kelsall. 1996. High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J. Immunol. 157:2348.
59. Brocke, S., K. Gijbels, M. Allegretta, I. Ferber, C. Piercy, T. Blankenstein, R. Martin, U. Utz, N. Karin, D. Mitchell, et al. 1996. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379: 343.
60. Kuruvilla, A. P., R. Shah, G. M. Hochwald, M. Liggitt, A. Palladino, and G. J. Thorbecke. 1991. Protective effect of transforming growth factor β1 on experimental autoimmune diseases in mice. Proc. Natl. Acad. Sci. USA 88:2918.
61. Racke, M. K., S. Dhib-Jalbut, B. Cannella, P. Albert, C. S. Raine, and D. E. McFarlin. 1991. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1. J. Immunol. 146: 3012.
62. Soos, J. M., P. S. Subramaniam, A. C. Hobeika, J. Schiffenbauer, and H. M. Johnson. 1995. The IFN pregnancy recognition hormone IFN-γ blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity. J. Immunol. 155:2747.
63. Santambrogio, L., G. M. Hochwald, B. Saxena, C.-H. Leu, J. E. Martz, J. A. Carlino, N. H. Ruddle, M. A. Palladino, L. I. Gold, and G. J. Thorbecke. 1993. Studies on the mechanism by which transforming growth factor-β (TGF-β) protects against allergic encephalomyelitis: antagonism between TGF-β and tumor necrosis factor. J. Immunol. 151:1116.
64. Baker, D., D. Butler, B. J. Scallon, J. K. O'Neill, and J. L. Turk. 1994. Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins. Eur. J. Immunol. 24:2040.
65. Hunter, C., L. Bermudez, H. Beernink, W. Waegell, and J. S. Remington. 1995. Transforming growth factor-β inhibits interleukin-12-induced production of interferon-γ by natural killer cells: a role for transforming growth factor-β in the regulation of T-cell independent resistance to Toxoplasma gondii. Eur. J. Immunol. 25:994.
66. Scharton-Kersten, T., L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154:5320.
67. Goverman, J., A. Woods, L. Larson, L. P. Weiner, L. Hood, and D. M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunily. Cell 72:551.
68. Lichtman, S. N., J. Wang, R. B. Sartor, C. Zhang, D. Bender, F. G. Dalldorf, and J. H. Schwab. 1995. Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: role of cytokines, bacteria, and bacterial polymers. Infect. Immun. 63:2295.
69. C. S. Constantinescu, B. D. Hondowicz, M. M. Ellosa, M. Wysocka, G. Trinchieri, and P. Scott. 1998. The role of IL-12 in the maintenance of an established Th1 response in experimental leishmaniasis. Eur. J. Immunol. 28: 2227.