In vivo dynamics of anti-viral CD8 T cell responses to different epitopes: An evaluation of bystander activation in primary and secondary responses to viral infection

Advances in Experimental Medicine and Biology

Volumn 452, Issue , 1998, Pages 123-142

  Murali Krishna, Kaja ^a   Altman, John D ^a   Suresh, M ^a   Sourdive, David ^a   Zajac, Allan ^a   Ahmed, Rafi ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CD8 ANTIGEN; CYTOKINE; EPITOPE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE;

ANIMAL CELL; ASSAY; CONFERENCE PAPER; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MALE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION;

ANIMALIA; VACCINIA;

EID: 0031722187     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5355-7_14     Document Type: Conference Paper

References (25)

1. Beverley PC: Is T cell memory maintained by crossreactive stimulation? Immunol. Today 11: 203-5, 1990.
2. Cao W, Tykodi SS, Esser MT, Braciale VL, Braciale TJ: Partial activation of CD8+ T cells by a self-derived peptide. Nature 378: 295-8, 1995.
3. Matzinger P: Immunology. Memories are made of this? Nature 369: 605-6, 1994.
4. Oldstone MB: Molecular mimicry and autoimmune disease. Cell 50: 819-20, 1987.
5. Tough DF, Borrow P, Sprent J: Induction of bystander T cell proliferation by viruses and type I interferon in vivo . Science 272: 1947-50, 1996.
6. Tough DF, Sprent J: Viruses and T cell turnover: evidence for bystander proliferation. Immunol. Rev. 150: 129-42, 1996.
7. Unutmaz D, Pileri P, Abrignani S: Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180:1159-64, 1994.
8. Zal T, Weiss S, Mellor A., Stockinger B: Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc. Natl. Acad. Sci. USA 93: 9102-7, 1996.
9. Ahmed R, Gray D: Immunological memory and protective immunity: understanding their relation. Science 272: 54-60, 1996.
10. Doherty PC, Allan W, Eichelberger M, Carding SR: Roles of alpha beta and gamma delta T cell subsets in viral immunity. Ann. Rev. Immunol. 10: 123-151, 1992.
11. Zinkernagel RM: Immunology taught by viruses. Science 271: 173-178, 1996.
12. Ehl S, Hombach J, Aichele P, HengartnerH, Zinkernagel RM: Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J. Exp. Med. 185: 1241-51, 1997.
13. Zarozinski CC, Welsh RM: Minimal bystander activation of CDS T cells during the virus-induced polyclonal T cell response. J .Exp. Med. 185: 1629-39, 1997.
14. Griffin D E: Immune responses during measles virus infection. Curr. Top. Microbiol. Immunol. 191: 117-34, 1995.
15. Ahmed R, Salmi A, Butler L D, Chiller J M, Oldstone MBA: Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp.Med.160: 521-40, 1984.
16. Borrow P, Tishon A, Lee S, Xu J, Grewal IS, Oldstone M B, Flavell RA: CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+CTL response. J. Exp. Med. 183: 2129-42, 1996.
17. Byrne JA, Ahmed R, Oldstone MBA: Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants. J. Immunol. 133: 433-9, 1984.
18. Fung-Leung WP, Kundig TM, Zinkernagel RM, Mak T W: Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J. Exp. Med. 174: 1425-9, 1991.
19. Gegin C, Lehmann Grube F: Control of acute infection with lymphocytic choriomeningitis virus in mice that cannot present an immunodominant viral cytotoxic T lymphocyte epitope. J. Immunol. 149: 3331-8, 1992.
20. Kagi D, Ledermann B, Burki K, Zinkernagel R M, Hengartner H: Molecular mechanisms of lymphocytemediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14: 207-32, 1996.
21. Matloubian M, Kolhekar S R, Somasundaram T, Ahmed R: Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus. J. Virol. 67: 7340-9, 1993.
22. McFarland H I, Nahill SR, Maciaszek JW, Welsh R M: CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection. J. Immunol. 149: 1326-33, 1992.
23. Moskophidis D, Fang L, Gossmann J, Lehmann Grube F: Mechanism of recovery from acute virus infection. IX. Clearance of lymphocytic choriomeningitis (LCM) virus from the feet of mice undergoing LCM virus-specific delayed-type hypersensitivity reaction. J. Gen. Virol. 70: 3305-16, 1989.
24. Moskophidis D, Lechner F, Pircher H, Zinkernagel R M: Virus persistence in acutely infected immuno-competent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362: 758-61, 1993.
25. van der Most RG, Sette A, Oseroff C, Alexander J, Murali-Krishna K, Lau LL, Southwood S, Sidney J, Chesnut RW, Matloubian M, Ahmed R: Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J. Immunol. 157: 5543-54, 1996.