Alteration of substrate specificity by mutations at the His61 position in predicted transmembrane domain 1 of human MDR1/P-Glycoprotein

Biochemistry

Volumn 36, Issue 29, 1997, Pages 8883-8889

  Taguchi, Yoshitomo ^a   Kino, Kouichi ^a   Morishima, Masaki ^a   Komano, Tohru ^a,c   Kane, Susan E ^b   Ueda, Kazumitsu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; COLCHICINE; COMPLEMENTARY DNA; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; ION CHANNEL; MEMBRANE PROTEIN; VINBLASTINE;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELL MEMBRANE TRANSPORT; DRUG SENSITIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING SITES; COLCHICINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DNA MUTATIONAL ANALYSIS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; FLUORESCEINS; FLUORESCENT DYES; HISTIDINE; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; P-GLYCOPROTEIN; PROTEIN STRUCTURE, TERTIARY; RHODAMINE 123; RHODAMINES; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0030858837     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970553v     Document Type: Article

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