Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 20449-20452

  Loo, Tip W ^b   Bartlett, M Claire ^b   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MATERIALS; CELLS; CHEMICAL ACTIVATION; DRUG PRODUCTS; SUBSTRATES;

PERMANENT ACTIVATION;

PROTEINS;

ADENOSINE TRIPHOSPHATASE; CALCEIN; COLCHICINE; CYCLOSPORIN A; DEMECOLCINE; DITHIOTHREITOL; FLUPENTIXOL; GLYCOPROTEIN P; METHANETHIOSULFONATE VERAPAMIL; NICKEL; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE;

ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROLYSIS; MULTIDRUG RESISTANCE; MUTAGENESIS; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; BINDING SITES; CELL LINE; CYSTEINE; HUMANS; KIDNEY; MESYLATES; MUTAGENESIS; P-GLYCOPROTEIN; PROTEIN STRUCTURE, TERTIARY; VERAPAMIL;

EID: 0038419822     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C300154200     Document Type: Article

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