PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells

Journal of Biological Chemistry

Volumn 281, Issue 17, 2006, Pages 11923-11932

  Yeung, Bonnie H Y ^a   Huang, Der Chen ^a   Sinicrope, Frank A ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; FLUORESCENCE; MICROSCOPIC EXAMINATION; OXYGEN; PROTEINS; RNA;

APOPTOSIS; KILODALTONS; LYSOSOMAL PERMEABILIZATION; MITOCHONDRIAL PERMEABILIZATION; PS-341 (BORTEZOMIB);

TUMORS;

BENZYLOXYCARBONYLVALYLASPARTYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BH3 PROTEIN; BIM PROTEIN; BONGKREKIC ACID; BORTEZOMIB; CASPASE 2; CASPASE INHIBITOR; CATHEPSIN B; CATHEPSIN B INHIBITOR; CYTOCHROME C; ENZYME INHIBITOR; KETONE DERIVATIVE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BIK; R 3032; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TIRON; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PERMEABILIZATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DEPOLARIZATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME RELEASE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LYSOSOME; MITOCHONDRIAL MEMBRANE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; STRESS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; BORONIC ACIDS; CASPASE 2; CATHEPSIN B; CYSTEINE ENDOPEPTIDASES; CYTOCHROMES C; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; LYSOSOMES; MEMBRANE PROTEINS; MITOCHONDRIAL MEMBRANES; PANCREATIC NEOPLASMS; PERMEABILITY; PHOSPHATIDYLSERINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRAZINES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 33744959426     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M508533200     Document Type: Article

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