Apoptosis signaling triggered by the marine alkaloid ascididemin is routed via caspase-2 and JNK to mitochondria

Oncogene

Volumn 23, Issue 8, 2004, Pages 1586-1593

  Dirsch, Verena M ^a   Kirschke, Stephanie O ^a   Estermeier, Michael ^a   Steffan, Bert ^a   Vollmar, Angelika M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Ascididemin; Caspase 2; Mitochondria

Indexed keywords

ALKALOID; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ASCIDIDEMIN; CASPASE 2; CASPASE 2 INHIBITOR; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYTOCHROME C; DNA FRAGMENT; FAS ANTIGEN; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; CASPASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PHENANTHROLINE DERIVATIVE; QUINOLINE DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRION; MULTIDRUG RESISTANCE; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; METABOLISM; TIME; TUMOR CELL LINE;

ALKALOIDS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; MAP KINASE KINASE 4; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHENANTHROLINES; QUINOLINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 1542426652     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207281     Document Type: Article

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