NF-κB inactivation converts a hepatocyte cell line TNF-α response from proliferation to apoptosis

American Journal of Physiology - Cell Physiology

Volumn 275, Issue 4 44-4, 1998, Pages

  Xu, Yang ^a   Bialik, Shani ^a   Jones, Brett E ^a   Iimuro, Yuji ^b   Kitsis, Richard N ^a   Srinivasan, Anu ^c   Brenner, David A ^b   Czaja, Mark J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c PFIZER INC   (United States)

Author keywords

Caspases; Hydrogen peroxide; Inducible nitric oxide synthase; Liver; Nitric oxide

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; CASPASE; CYSTEINE PROTEINASE INHIBITOR; DNA; DNA BINDING PROTEIN; DRUG DERIVATIVE; I KAPPA B; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE DONOR; PENICILLAMINE; RECOMBINANT PROTEIN; THYMIDINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CYTOTOXICITY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BIOSYNTHESIS; CELL DIVISION; CELL LINE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; METABOLISM; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CASPASES; CELL DIVISION; CELL LINE; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; I-KAPPA B PROTEINS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE DONORS; PENICILLAMINE; RATS; RECOMBINANT PROTEINS; S-NITROSO-N-ACETYLPENICILLAMINE; THYMIDINE; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032185680     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1998.275.4.c1058     Document Type: Article

References (38)

1. Akerman, P., Y. Cote, S. Q. Yang, C. McClain, S. Nelson, G. J. Bagby, and A. M. Diehl. Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy. Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26): G579-G585, 1992.
2. Beg, A. A., and D. Baltimore. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274: 782-784, 1996.
3. Bellas, R. E., M. J. FitzGerald, N. Fausto, and G. E. Sonenshein. Inhibition of NF-κB activity induces apoptosis in murine hepatocytes. Am. J. Path. 15: 891-896, 1997.
4. Blazka, M. E., J. L. Wilmer, S. D. Holladay, R. E. Wilson, and M. I. Luster. Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol. Appl. Pharmacol. 133: 43-52, 1995.
5. Chamulitrat, W., S. J. Jordan, and R. P. Mason. Nitric oxide production during endotoxic shock in carbon tetrachloride-treated rats. Mol. Pharmacol. 46: 391-397, 1994.
6. Chou, J. Y. Temperature-sensitive adult liver cell line dependent on glucocorticoid for differentiation. Mol. Cell. Biol. 3: 1013-1020, 1983.
7. Chu, Z.-L., T. A. McKinsey, L. Liu, J. J. Gentry, M. H. Malim, and D. W. Ballard. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc. Natl. Acad. Sci. USA 94: 10057-10062, 1997.
8. Czaja, M. J., K. C. Flanders, L. Biempica, C. Klein, M. A. Zern, and F. R. Weiner. Expression of tumor necrosis factor-α and transforming growth factor-β1 in acute rat liver injury. Growth Factors 1: 219-226, 1989.
9. Czaja, M. J., M. L. Schilsky, Y. Xu, P. Schmiedeberg, A. Compton, L. Ridnour, and L. W. Oberley. Induction of MnSOD gene expression in a hepatic model of TNF-α toxicity does not result in increased protein. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G737-G744, 1994.
10. Czaja, M. J., F. R. Weiner, K. C. Flanders, M. A. Giambrone, R. Wind, L. Biempica, and M. A. Zern. The in vitro and in vivo association of transforming growth factor-β with hepatic fibrosis. J. Cell Biol. 108: 2477-2482, 1989.
11. Czaja, M. J., J. Xu, and E. Alt. Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor. Gastroenterology 108: 1849-1854, 1995.
12. Denizat, F., and R. Lang. Rapid colorimetric assay for cell growth and survival. J. Immunol. Methods 89: 271-277, 1986.
13. Diehl, A. M., D. C. Johns, S. Q. Yang, H. Z. Lin, M. Yin, L. A. Matelis, and J. H. Lawrence. Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-α identifies a dominant anti-proliferative role for this isoform in hepatocytes. J. Biol. Chem. 271: 7343-7350, 1996.
14. Dimmeler, S., J. Haendeler, M. Nehls, and A. M. Zeiher. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J. Exp. Med. 185: 601-607, 1997.
15. Dimmeler, S., and A. M. Zeiher. Nitric oxide and apoptosis: another paradigm for the double-edged role of nitric oxide. Nitric Oxide 1: 275-281, 1997.
16. Galang, C. K., C. J. Der, and C. A. Hauser. Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. Oncogene 9: 2913-2921, 1994.
17. Geller, D. A., A. K. Nussler, M. Di Silvio, C. J. Lowenstein, R. A. Shapiro, S. C. Wang, R. L. Simmons, and T. R. Billiar. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. USA 90: 522-526, 1993.
18. Hishinuma, I., J. I. Nagakawa, K. Hirota, K. Miyamoto, K. Tsukidate, T. Yamanaka, K. I. Katayama, and I. Yamatsu. Involvement of tumor necrosis factor-α in development of hepatic injury in galactosamine-sensitized mice. Hepatology 12: 1187-1191, 1990.
19. Iimuro, Y., T. Nishiura, C. Hellerbrand, K. Behrns, R. Schoonhoven, J. W. Grisham, and D. A. Brenner. NF-κB prevents apoptosis and liver dysfunction during liver regeneration. J. Clin. Invest. 101: 802-811, 1998.
20. 2. J. Clin. Invest. 89: 794-802, 1992.
21. Kayama, F., T. Yoshida, M. R. Elwell, and M. I. Luster. Role of tumor necrosis factor-α in cadmium-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 131: 224-234, 1995.
22. Kim, Y.-M., M. E. deVera, S. C. Watkins, and T. R. Billiar. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-α-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272: 1402-1411, 1997.
23. Kull, F. C., and P. Cuatrecasas. Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum. Cancer Res. 41: 4885-4890, 1981.
24. LaBarca, C., and K. Paigen. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102: 344-352. 1980.
25. Liu, Z., H. Hsu, D. V. Goeddel, and M. Karin. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87: 565-576, 1996.
26. McClain, C. J., and D. A. Cohen. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 9: 349-351, 1989.
27. Salvesen, G. S., and V. M. Dixit. Caspases: intracellular signaling by proteolysis. Cell 91: 443-446, 1997.
28. Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. Rapid detection of octamer binding proteins with "mini-extracts" prepared from a small number of cells. Nucleic Acids Res. 17: 6419, 1989.
29. L functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J. Biol. Chem. 273: 4523-4529, 1998.
30. Tracy, K. J. Tumor necrosis factor. In: Cytokine in Health and Disease, edited by D. G. Remick and J. S. Friedland. New York: Marcel Dekker, 1997, p. 223-240.
31. Van Antwerp, D. J., S. J. Martin, T. Kafri, D. R. Green, and I. M. Verma. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274: 787-789, 1996.
32. Wang, C.-Y., M. W. Mayo, and A. S. Baldwin, Jr. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274: 784-787, 1996.
33. Wang, X., N. G. Zelenski, J. Yang, J. Sakai, M. S. Brown, and J. L. Goldstein. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 15: 1012-1020, 1996.
34. Wong, G. H. W., J. H. Elwell, L. W. Oberley, and D. V. Goeddel. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell 58: 923-931, 1989.
35. Xu, J., Y. Xu, Q. Nguyen, P. M. Novikoff, and M. J. Czaja. The induction of hepatoma cell apoptosis by c-myc requires zinc and occurs in the absence of DNA fragmentation. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G60-G70, 1996.
36. Yamada, Y., I. Kirillova, J. J. Peschon, and N. Fausto. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I TNF receptor. Proc. Natl. Acad. Sci. USA 94: 1441-1446, 1997.
37. Yoshioka, K., S. Kakumu, M. Arao, Y. Tsutsumi, and M. Inoue. Tumor necrosis factor-α production by peripheral blood mononuclear cells of patients with chronic liver disease. Hepatology 10: 769-773, 1989.
38. Yuan, J. Transforming signals of life and death. Curr. Opin. Cell Biol. 9: 247-251, 1997.