-
1
-
-
0031916439
-
The Ras/Racl/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes
-
Auer, K., J. Contessa, S. Brenz-Verca, L. Pirola, S. Rusconi, G. Cooper, A. Abo, M. Wymann, R. J. Davis, M. Birrer, and P. Dent. 1998. The Ras/Racl/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Mol. Biol. Cell 9:561-573.
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 561-573
-
-
Auer, K.1
Contessa, J.2
Brenz-Verca, S.3
Pirola, L.4
Rusconi, S.5
Cooper, G.6
Abo, A.7
Wymann, M.8
Davis, R.J.9
Birrer, M.10
Dent, P.11
-
2
-
-
0025259573
-
Cholecystocolonic fistula: Malabsorptive consequences of lost bile acids
-
Benage, D., and K. W. O'Connor. 1990. Cholecystocolonic fistula: malabsorptive consequences of lost bile acids. J. Clin. Gastroenterol. 12:192-194.
-
(1990)
J. Clin. Gastroenterol.
, vol.12
, pp. 192-194
-
-
Benage, D.1
O'Connor, K.W.2
-
3
-
-
0033375042
-
The significance of apoptosis in the liver
-
Benedetti, A., and L. Marucci. 1999. The significance of apoptosis in the liver. Liver 19:453-463
-
(1999)
Liver
, vol.19
, pp. 453-463
-
-
Benedetti, A.1
Marucci, L.2
-
4
-
-
0035795633
-
Identification of a novel DNA regulatory element in the rabbit surfactant protein B (SP-B) promoter that is a target for ATF/CREB and AP-1 transcription factors
-
Berhane, K., and V. Boggaram. 2001, Identification of a novel DNA regulatory element in the rabbit surfactant protein B (SP-B) promoter that is a target for ATF/CREB and AP-1 transcription factors. Gene 268:141-151.
-
(2001)
Gene
, vol.268
, pp. 141-151
-
-
Berhane, K.1
Boggaram, V.2
-
6
-
-
0032698075
-
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
-
Bonni, A., A. Brunet, A. E. West, S. R. Datta, M. A. Takasu, and M. E. Greenberg. 1999. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286: 1358-1362.
-
(1999)
Science
, vol.286
, pp. 1358-1362
-
-
Bonni, A.1
Brunet, A.2
West, A.E.3
Datta, S.R.4
Takasu, M.A.5
Greenberg, M.E.6
-
7
-
-
0028816461
-
Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
-
Botla, R., J. Spivey, H. Aguilar, S. F. Bronk, and G. Gores. 1995. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. J. Pharmacol. Exp. Ther. 272:930-938.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.272
, pp. 930-938
-
-
Botla, R.1
Spivey, J.2
Aguilar, H.3
Bronk, S.F.4
Gores, G.5
-
8
-
-
0031663583
-
Signal transduction during liver regeneration
-
Brenner, D. A. 1998. Signal transduction during liver regeneration. J. Gastroenterol. Hepatol. 13:S93-S95.
-
(1998)
J. Gastroenterol. Hepatol.
, vol.13
-
-
Brenner, D.A.1
-
9
-
-
0033369990
-
Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBPβ is required for hepatocyte proliferation induced by TGF α
-
Buck, M., V. Poli, P. van der Geer, M. Chojkier, and T. Hunter. 1999. Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBPβ is required for hepatocyte proliferation induced by TGF α. Mol. Cell 4:1087-1092.
-
(1999)
Mol. Cell
, vol.4
, pp. 1087-1092
-
-
Buck, M.1
Poli, V.2
Van der Geer, P.3
Chojkier, M.4
Hunter, T.5
-
10
-
-
17444454260
-
Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS
-
Cohen-Jonathan, E., R. J. Muschel, G. W. McKenna, S. M. Evans, G. Cerniglia, R. Mick, D. Kusewitt, S. M. Sebti, A. D. Hamilton, A. Oliff, N. Kohl, J. B. Gibbs, and E. J. Bernhard. 2000. Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS. Radiat. Res. 154:125-132.
-
(2000)
Radiat. Res.
, vol.154
, pp. 125-132
-
-
Cohen-Jonathan, E.1
Muschel, R.J.2
McKenna, G.W.3
Evans, S.M.4
Cerniglia, G.5
Mick, R.6
Kusewitt, D.7
Sebti, S.M.8
Hamilton, A.D.9
Oliff, A.10
Kohl, N.11
Gibbs, J.B.12
Bernhard, E.J.13
-
11
-
-
0032815618
-
Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death
-
Dent, P., D. B. Reardon, J. S. Park, G. Bowers, C. Logsdon, K. Valerie, and R. K. Schmidt-Ullrich. 1999. Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol. Biol. Cell 10:2493-2506.
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 2493-2506
-
-
Dent, P.1
Reardon, D.B.2
Park, J.S.3
Bowers, G.4
Logsdon, C.5
Valerie, K.6
Schmidt-Ullrich, R.K.7
-
12
-
-
0031759748
-
The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemosensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity
-
Dent, P., W. D. Jarvis, M. J. Birrer, P. B. Fisher, R. K. Schmidt-Ullrich, and S. Grant. 1998. The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemosensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity. Leukemia 12:400-408.
-
(1998)
Leukemia
, vol.12
, pp. 400-408
-
-
Dent, P.1
Jarvis, W.D.2
Birrer, M.J.3
Fisher, P.B.4
Schmidt-Ullrich, R.K.5
Grant, S.6
-
13
-
-
0032919402
-
Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
-
Faubion, W. A., M. E. Guicciardi, H. Miyoshi, S. F. Bronk, P. J. Roberts, P. A. Svingen, S. H. Kaufmann, and G. J. Gores. 1999. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J. Clin. Investig. 103:137-145.
-
(1999)
J. Clin. Investig.
, vol.103
, pp. 137-145
-
-
Faubion, W.A.1
Guicciardi, M.E.2
Miyoshi, H.3
Bronk, S.F.4
Roberts, P.J.5
Svingen, P.A.6
Kaufmann, S.H.7
Gores, G.J.8
-
14
-
-
0034672645
-
CREB is cleaved by caspases during neural cell apoptosis
-
Francois, F., M. J. Godinho, and M. L. Grimes. 2000. CREB is cleaved by caspases during neural cell apoptosis. FEBS Lett. 486:281-284.
-
(2000)
FEBS Lett.
, vol.486
, pp. 281-284
-
-
Francois, F.1
Godinho, M.J.2
Grimes, M.L.3
-
15
-
-
0032504695
-
Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: A potential role for mitochondrial proteases
-
Gores, G. J., H. Miyoshi, R. Botla, H. I. Aguilar, and S. F. Bronk. 1998. Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: a potential role for mitochondrial proteases. Biochim. Biophys. Acta 1366:167-175.
-
(1998)
Biochim. Biophys. Acta
, vol.1366
, pp. 167-175
-
-
Gores, G.J.1
Miyoshi, H.2
Botla, R.3
Aguilar, H.I.4
Bronk, S.F.5
-
16
-
-
0035844156
-
Down-regulation of cholesterol 7 α-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway
-
Gupta, S., R. T. Stravitz, P. Dent, and P. B. Hylemon. 2001. Down-regulation of cholesterol 7 α-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J. Biol. Chem. 276:15816-15822.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 15816-15822
-
-
Gupta, S.1
Stravitz, R.T.2
Dent, P.3
Hylemon, P.B.4
-
17
-
-
0035254521
-
Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
-
Harari, P. M., and S. Huang. 2001. Head and neck cancer as a clinical model for molecular targeting of therapy: combining EGFR blockade with radiation. Int. J. Radiat. Oncol. Biol. Phys. 49:427-433.
-
(2001)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.49
, pp. 427-433
-
-
Harari, P.M.1
Huang, S.2
-
18
-
-
0035914341
-
The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis
-
Higuchi, H., S. F. Bronk, Y. Takikawa, N. Werneburg, R. Takimoto, W. El-Deiry, and G. J. Gores. 2001. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. J. Biol. Chem. 276: 38610-38618.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38610-38618
-
-
Higuchi, H.1
Bronk, S.F.2
Takikawa, Y.3
Werneburg, N.4
Takimoto, R.5
El-Deiry, W.6
Gores, G.J.7
-
19
-
-
85047700485
-
Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis
-
Hochedlinger, K., E. F. Wagner, and K. Sabapathy. 2002. Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. Oncogene 21:2441-2445.
-
(2002)
Oncogene
, vol.21
, pp. 2441-2445
-
-
Hochedlinger, K.1
Wagner, E.F.2
Sabapathy, K.3
-
20
-
-
0015412556
-
The roles of bile acids during the process of normal fat and cholesterol absorption
-
Holt, P. R. 1972. The roles of bile acids during the process of normal fat and cholesterol absorption. Arch. Intern. Med. 130:574-583.
-
(1972)
Arch. Intern. Med.
, vol.130
, pp. 574-583
-
-
Holt, P.R.1
-
21
-
-
0031785213
-
Evidence for involvement of mitogenactivated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling
-
Jarvis, W. D., F. A. Fornari, R. M. Tombes, R. K. Erukulla, R. Bittman, G. K. Schwartz, P. Dent, and S. Grant. 1998. Evidence for involvement of mitogenactivated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. Mol. Pharmacol. 54:844-856.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 844-856
-
-
Jarvis, W.D.1
Fornari, F.A.2
Tombes, R.M.3
Erukulla, R.K.4
Bittman, R.5
Schwartz, G.K.6
Dent, P.7
Grant, S.8
-
22
-
-
0033649270
-
Mechanisms of liver cell injury
-
Kaplowitz, N. 2000. Mechanisms of liver cell injury. J. Hepatol. 32:39-47.
-
(2000)
J. Hepatol.
, vol.32
, pp. 39-47
-
-
Kaplowitz, N.1
-
23
-
-
12644257582
-
Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver
-
Koeppel, T. A., M. Trauner, J. C. Baas, J. C. Thies, S. F. Schlosser, S. Post, M. M. Gebhard, C. Herfarth, J. L. Boyer, and G. Otto. 1997. Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology 26:1085-1091.
-
(1997)
Hepatology
, vol.26
, pp. 1085-1091
-
-
Koeppel, T.A.1
Trauner, M.2
Baas, J.C.3
Thies, J.C.4
Schlosser, S.F.5
Post, S.6
Gebhard, M.M.7
Herfarth, C.8
Boyer, J.L.9
Otto, G.10
-
24
-
-
0037198169
-
Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis
-
Koo, M. S., Y. G. Kwo, J. H. Park, W. J. Choi, T. R. Billiar, and Y. M. Kim. 2002. Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. Mol. Cell 13:194-201.
-
(2002)
Mol. Cell
, vol.13
, pp. 194-201
-
-
Koo, M.S.1
Kwo, Y.G.2
Park, J.H.3
Choi, W.J.4
Billiar, T.R.5
Kim, Y.M.6
-
25
-
-
0035854780
-
Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL
-
Kovalovich, K., W. Li, R. DeAngelis, L. E. Greenbaum, G. Ciliberto, and R. Taub. 2001. Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J. Biol. Chem. 276:26605-26613.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26605-26613
-
-
Kovalovich, K.1
Li, W.2
DeAngelis, R.3
Greenbaum, L.E.4
Ciliberto, G.5
Taub, R.6
-
26
-
-
0028091169
-
Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria
-
Krahenbuhl, S., C. Talos, S. Fischer, and J. Reichen. 1994. Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria. Hepatology 19:471-479.
-
(1994)
Hepatology
, vol.19
, pp. 471-479
-
-
Krahenbuhl, S.1
Talos, C.2
Fischer, S.3
Reichen, J.4
-
27
-
-
0033118607
-
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
-
Kuan, C. Y., D. D. Yang, D. R. Samanta Roy, R. J. Davis, P. Rakic, and R. A. Flavell. 1999. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22:667-676.
-
(1999)
Neuron
, vol.22
, pp. 667-676
-
-
Kuan, C.Y.1
Yang, D.D.2
Samanta Roy, D.R.3
Davis, R.J.4
Rakic, P.5
Flavell, R.A.6
-
28
-
-
0028911047
-
Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes
-
Kwo, P., T. Patel, S. Bronk, and G. Gores. 1995. Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes. Am. J. Physiol. 268:G613-G621.
-
(1995)
Am. J. Physiol.
, vol.268
-
-
Kwo, P.1
Patel, T.2
Bronk, S.3
Gores, G.4
-
29
-
-
0037013331
-
Activation of constitutive nitric-oxide synthase activity is an early signaling event induced by ionizing radiation
-
Leach, J. K., S. M. Black, R. K. Schmidt-Ullrich, and P. B. Mikkelsen. 2002. Activation of constitutive nitric-oxide synthase activity is an early signaling event induced by ionizing radiation. J. Biol. Chem. 277:15400-15406.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 15400-15406
-
-
Leach, J.K.1
Black, S.M.2
Schmidt-Ullrich, R.K.3
Mikkelsen, P.B.4
-
30
-
-
0036329891
-
Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells
-
Liedtke, C., J. Plumpe, S. Kubicka, C. A. Bradham, M. P. Manns, D. A. Brenner, and C. Trautwein. 2002. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Hepatology 36:315-325.
-
(2002)
Hepatology
, vol.36
, pp. 315-325
-
-
Liedtke, C.1
Plumpe, J.2
Kubicka, S.3
Bradham, C.A.4
Manns, M.P.5
Brenner, D.A.6
Trautwein, C.7
-
31
-
-
0033900954
-
Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-κB, activation protein-1, and c-Jun N-terminal kinase
-
Manna, S. K., V. Haridas, and B. B. Aggarwal. 2000. Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-κB, activation protein-1, and c-Jun N-terminal kinase. J. Interferon Cytokine Res. 20:725-735.
-
(2000)
J. Interferon Cytokine Res.
, vol.20
, pp. 725-735
-
-
Manna, S.K.1
Haridas, V.2
Aggarwal, B.B.3
-
32
-
-
0033630308
-
Serine/threonine phosphorylation in cytokine signal transduction
-
McCubrey, J. A., W. S. May, V. Duronio, and A. Mufson. 2000. Serine/threonine phosphorylation in cytokine signal transduction. Leukemia 14:9-21.
-
(2000)
Leukemia
, vol.14
, pp. 9-21
-
-
McCubrey, J.A.1
May, W.S.2
Duronio, V.3
Mufson, A.4
-
33
-
-
0031969138
-
Effect of high concentrations of bile acids on cultured hepatocytes
-
Noto, H., M. Matsushita, M. Koike, M. Takahashi, H. Matsue, J. Kimura, and S. Todo. 1998. Effect of high concentrations of bile acids on cultured hepatocytes. Artif. Organs 22:300-307.
-
(1998)
Artif. Organs
, vol.22
, pp. 300-307
-
-
Noto, H.1
Matsushita, M.2
Koike, M.3
Takahashi, M.4
Matsue, H.5
Kimura, J.6
Todo, S.7
-
34
-
-
0033378009
-
c-raf-1 depletion and tumor responses in patients treated with the c-raf-1 antisense oligodeoxynucleotide ISIS 5132 (CGP 69846A)
-
O'Dwyer, P. J., J. P. Stevenson, M. Gallagher, A. Cassella, I. Vasilevskaya, B. P. Monia, J. Holmlund, F. A. Dorr, and K. S. Yao. 1999. c-raf-1 depletion and tumor responses in patients treated with the c-raf-1 antisense oligodeoxynucleotide ISIS 5132 (CGP 69846A). Clin. Cancer Res. 5:3977-3982.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 3977-3982
-
-
O'Dwyer, P.J.1
Stevenson, J.P.2
Gallagher, M.3
Cassella, A.4
Vasilevskaya, I.5
Monia, B.P.6
Holmlund, J.7
Dorr, F.A.8
Yao, K.S.9
-
35
-
-
0034490479
-
A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes
-
Park, J. S., L. Qiao, G. Gilfor, M. Y. Yang, P. B. Hylemon, C. Benz, G. Darlington, G. Firestone, P. B. Fisher, and P. Dent. 2000. A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes. Mol. Biol. Cell 11:2915-2932.
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 2915-2932
-
-
Park, J.S.1
Qiao, L.2
Gilfor, G.3
Yang, M.Y.4
Hylemon, P.B.5
Benz, C.6
Darlington, G.7
Firestone, G.8
Fisher, P.B.9
Dent, P.10
-
36
-
-
0035930905
-
Alternative splicing variants of c-FLIP transduce the differential signal through the Raf or TRAF2 in TNF-induced cell proliferation
-
Park, S. J., Y. Y. Kim, J. W. Ju, B. G. Han, S. I. Park, and B. J. Park. 2001. Alternative splicing variants of c-FLIP transduce the differential signal through the Raf or TRAF2 in TNF-induced cell proliferation. Biochem. Biophys. Res. Commun. 289:1205-1210.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.289
, pp. 1205-1210
-
-
Park, S.J.1
Kim, Y.Y.2
Ju, J.W.3
Han, B.G.4
Park, S.I.5
Park, B.J.6
-
37
-
-
0028135420
-
Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes
-
Patel, T., S. Bronk, and G. Gores. 1994. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J. Clin. Investig. 94:2183-2192.
-
(1994)
J. Clin. Investig.
, vol.94
, pp. 2183-2192
-
-
Patel, T.1
Bronk, S.2
Gores, G.3
-
39
-
-
0036288670
-
Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53
-
Qiao, L., R. McKinstry, S. Gupta, D. Gilfor, J. J. Windle, P. B. Hylemon, S. Grant, P. B. Fisher, and P. Dent. 2002. Cyclin kinase inhibitor p21 potentiates bile acid-induced apoptosis in hepatocytes that is dependent on p53. Hepatology 36:39-48.
-
(2002)
Hepatology
, vol.36
, pp. 39-48
-
-
Qiao, L.1
McKinstry, R.2
Gupta, S.3
Gilfor, D.4
Windle, J.J.5
Hylemon, P.B.6
Grant, S.7
Fisher, P.B.8
Dent, P.9
-
40
-
-
0036211298
-
Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes
-
Qiao, L., A. Yacoub, E. Studer, S. Gupta, X. Y. Pei, S. Grant, P. B. Hylemon, and P. Dent. 2002. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 35: 779-789.
-
(2002)
Hepatology
, vol.35
, pp. 779-789
-
-
Qiao, L.1
Yacoub, A.2
Studer, E.3
Gupta, S.4
Pei, X.Y.5
Grant, S.6
Hylemon, P.B.7
Dent, P.8
-
41
-
-
0035167269
-
Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis
-
Qiao, L., E. Studer, K. Leach, R. McKinstry, S. Gupta, R. Decker, R. Kukreja, K. Valerie, P. Nagarkatti, W. El Deiry, J. Molkentin, R. Schmidt-Ullrich, P. B. Fisher, S. Grant, P. B. Hylemon, and P. Dent. 2001. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis. Mol. Biol. Cell 12:2629-2645.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 2629-2645
-
-
Qiao, L.1
Studer, E.2
Leach, K.3
McKinstry, R.4
Gupta, S.5
Decker, R.6
Kukreja, R.7
Valerie, K.8
Nagarkatti, P.9
El Deiry, W.10
Molkentin, J.11
Schmidt-Ullrich, R.12
Fisher, P.B.13
Grant, S.14
Hylemon, P.B.15
Dent, P.16
-
42
-
-
0031459956
-
Activation of protein kinase C alpha and delta by bile acids: Correlation with bile acid structure and diacylglycerol formation
-
Rao, Y. P., R. T. Stravitz, Z. R. Vlahcevic, E. C. Gurley, J. J. Sando, and P. B. Hylemon. 1997. Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. J. Lipid Res. 38:2446-2454.
-
(1997)
J. Lipid Res.
, vol.38
, pp. 2446-2454
-
-
Rao, Y.P.1
Stravitz, R.T.2
Vlahcevic, Z.R.3
Gurley, E.C.4
Sando, J.J.5
Hylemon, P.B.6
-
43
-
-
0033584391
-
Dominant-negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells
-
Reardon, D. B., J. N. Contessa, R. B. Mikkelsen, K. Valerie, P. Dent, and R. K. Schmidt-Ullrich. 1999. Dominant-negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells. Oncogene 18:4756-4766.
-
(1999)
Oncogene
, vol.18
, pp. 4756-4766
-
-
Reardon, D.B.1
Contessa, J.N.2
Mikkelsen, R.B.3
Valerie, K.4
Dent, P.5
Schmidt-Ullrich, R.K.6
-
44
-
-
0032562704
-
Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha
-
Roulston, A., C. Reinhard, P. Amiri, and L. T. Williams. 1998. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor alpha. J. Biol. Chem. 273:10232-10239.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10232-10239
-
-
Roulston, A.1
Reinhard, C.2
Amiri, P.3
Williams, L.T.4
-
45
-
-
0034059884
-
Signal transduction and cellular radiation responses
-
Schmidt-Ullrich, R. K., P. Dent, S. Grant, R. B. Mikkelsen, and K. Valerie. 2000. Signal transduction and cellular radiation responses. Radiat. Res. 153:245-257.
-
(2000)
Radiat. Res.
, vol.153
, pp. 245-257
-
-
Schmidt-Ullrich, R.K.1
Dent, P.2
Grant, S.3
Mikkelsen, R.B.4
Valerie, K.5
-
46
-
-
0032984348
-
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
-
Sebolt-Leopold, J. S., D. T. Dudley, R. Herrera, K. Van Becelaere, A. Wiland, R. C. Gowan, H. Tecle, S. D. Barrett, A. Bridges, S. Przybranowski, W. R. Leopold, and A. R. Saltiel. 1999. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat. Med. 5:810-816.
-
(1999)
Nat. Med.
, vol.5
, pp. 810-816
-
-
Sebolt-Leopold, J.S.1
Dudley, D.T.2
Herrera, R.3
Van Becelaere, K.4
Wiland, A.5
Gowan, R.C.6
Tecle, H.7
Barrett, S.D.8
Bridges, A.9
Przybranowski, S.10
Leopold, W.R.11
Saltiel, A.R.12
-
47
-
-
0033936183
-
Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas
-
Sodeman, T., S. F. Bronk, P. J. Roberts, H. Miyoshi, and G. J. Gores. 2000. Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas. Am. J. Physiol. Gastrointest. Liver Physiol. 278:G992-G999.
-
(2000)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.278
-
-
Sodeman, T.1
Bronk, S.F.2
Roberts, P.J.3
Miyoshi, H.4
Gores, G.J.5
-
48
-
-
0027227827
-
Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
-
Spivey, J. R., S. Bronk, and G. Gores. 1993. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J. Clin. Investig. 92:17-24.
-
(1993)
J. Clin. Investig.
, vol.92
, pp. 17-24
-
-
Spivey, J.R.1
Bronk, S.2
Gores, G.3
-
49
-
-
0034108838
-
Growth hormone induces CCAAT/enhancer binding protein α (C/EBPα) in cultured rat hepatocytes
-
Strand, P., L. Carlsson, K. Rask, S. Skrtic, S. Ekberg, L. Hedin, J. Oscarsson, and J. O. Jansson. 2000. Growth hormone induces CCAAT/enhancer binding protein α (C/EBPα) in cultured rat hepatocytes. J. Hepatol. 32:618626.
-
(2000)
J. Hepatol.
, vol.32
, pp. 618626
-
-
Strand, P.1
Carlsson, L.2
Rask, K.3
Skrtic, S.4
Ekberg, S.5
Hedin, L.6
Oscarsson, J.7
Jansson, J.O.8
-
50
-
-
0029792502
-
Hepatocellular protein kinase C activation by bile acids: Implications for regulation of cholesterol 7 alpha-hydroxylase
-
Stravitz, R. T., Y. P. Rao, Z. R. Vlahcevic, E. C. Gurley, W. D. Jarvis, and P. B. Hylemon. 1996. Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase. Am. J. Physiol. 271:G293-G303.
-
(1996)
Am. J. Physiol.
, vol.271
-
-
Stravitz, R.T.1
Rao, Y.P.2
Vlahcevic, Z.R.3
Gurley, E.C.4
Jarvis, W.D.5
Hylemon, P.B.6
-
51
-
-
0032521642
-
The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic
-
Tombes, R. M., K. L. Auer, R. Mikkelsen, K. Valerie, M. P. Wymann, C. J. Marshall, M. McMahon, and P. Dent. 1998. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. Biochem. J. 330:1451-1460.
-
(1998)
Biochem. J.
, vol.330
, pp. 1451-1460
-
-
Tombes, R.M.1
Auer, K.L.2
Mikkelsen, R.3
Valerie, K.4
Wymann, M.P.5
Marshall, C.J.6
McMahon, M.7
Dent, P.8
-
52
-
-
0032080399
-
Concanavalin A-induced liver injury triggers hepatocyte proliferation
-
Trautwein, C., T. Rakemann, N. P. Malek, J. Plumpe, G. Tiegs, and M. P. Manns. 1998. Concanavalin A-induced liver injury triggers hepatocyte proliferation. J. Clin. Investig. 101:1960-1969.
-
(1998)
J. Clin. Investig.
, vol.101
, pp. 1960-1969
-
-
Trautwein, C.1
Rakemann, T.2
Malek, N.P.3
Plumpe, J.4
Tiegs, G.5
Manns, M.P.6
-
53
-
-
0033970607
-
Hepatocyte growth factor increases in injured organs and functions as an organotrophic factor in rats with experimental acute pancreatitis
-
Ueda, T., Y. Takeyama, Y. Hori, M. Shinkai, K. Takase, M. Goshima, M. Yamamoto, and Y. Kuroda. 2000. Hepatocyte growth factor increases in injured organs and functions as an organotrophic factor in rats with experimental acute pancreatitis. Pancreas 20:84-93.
-
(2000)
Pancreas
, vol.20
, pp. 84-93
-
-
Ueda, T.1
Takeyama, Y.2
Hori, Y.3
Shinkai, M.4
Takase, K.5
Goshima, M.6
Yamamoto, M.7
Kuroda, Y.8
-
54
-
-
0035123848
-
Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes
-
Webster, C. R., and M. S. Anwer. 2001. Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. Hepatology 33:608-615.
-
(2001)
Hepatology
, vol.33
, pp. 608-615
-
-
Webster, C.R.1
Anwer, M.S.2
-
55
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu, J., L. Zhang, P. M. Hwang, K. W. Kinzler, and B. Vogelstein. 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7:673-682.
-
(2001)
Mol. Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Kinzler, K.W.4
Vogelstein, B.5
-
56
-
-
0037039312
-
CCAAT/enhancer binding protein-β is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling
-
Zhu, S., K. Yoon, E. Sterneck, P. F. Johnson, and R. C. Smart. 2002. CCAAT/enhancer binding protein-β is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Proc. Natl. Acad. Sci. USA 99:207-212.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 207-212
-
-
Zhu, S.1
Yoon, K.2
Sterneck, E.3
Johnson, P.F.4
Smart, R.C.5
|