Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 9, 2004, Pages 2041-2046

  Sun, Lichun ^a   Vasilevich, Natalya I ^a   Fuselier, Joseph A ^a   Hocart, Simon J ^a   Coy, David H ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Lactams; 1,4 Diaryl 2 azetidinones; Anti tumor; Combretastatin A 4 analogues; Cytotoxicity; Tubulin polymerization

Indexed keywords

ANILINE DERIVATIVE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; AZETIDINONE DERIVATIVE; COMBRETASTATIN;

ARTICLE; CANCER INHIBITION; COLON CARCINOMA; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; GLIOBLASTOMA; HUMAN; HUMAN CELL; IC 50; KIDNEY CARCINOMA; LEUKEMIA; LUNG CARCINOMA; NEUROBLASTOMA; NONHUMAN; NUDE MOUSE; PANCREAS TUMOR; PROSTATE CARCINOMA; REACTION ANALYSIS; STAUDINGER REACTION; STEREOCHEMISTRY; SUBSTITUTION REACTION; TUMOR CELL LINE; UTERINE CERVIX CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; AZETIDINES; CELL LINE, TUMOR; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; RATS; STILBENES;

MUS MUSCULUS;

EID: 1842741030     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.02.050     Document Type: Article

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