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Volumn 8, Issue 22, 1998, Pages 3153-3158

Syntheses and antitumor activity of cis-restricted combretastatins: 5- membered heterocyclic analogues

Author keywords

[No Author keywords available]

Indexed keywords

AC 7739; ANTINEOPLASTIC AGENT; COLCHICINE; COMBRETASTATIN DERIVATIVE; HETEROCYCLIC COMPOUND; SERINE 2 METHOXY 5 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]ANILIDE; TUBULIN; UNCLASSIFIED DRUG;

EID: 0032542045     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00579-4     Document Type: Article
Times cited : (203)

References (22)
  • 1
    • 0019988507 scopus 로고
    • 1. Pettit, G. R.; Cragg, G. M.; Herald, D. L.; Schmidt, J. M.; Lohavanijaya, P. Can. J. Chem. 1982, 60, 1374. Pettit, G. R.; Singh, S. B.; Hamel, E.; Lin, C. M.; Alberts, D. S.; Garcia-Kendall, D. Experientia 1989, 45, 209. Hamel, E.; Lin, C. M. Biochem. Pharmacol. 1983, 32, 3864. Lin, C. M.; Ho, H. H.; Pettit, G. R.; Hamel, E. Biochemistry 1989, 28, 6984.
    • (1982) Can. J. Chem. , vol.60 , pp. 1374
    • Pettit, G.R.1    Cragg, G.M.2    Herald, D.L.3    Schmidt, J.M.4    Lohavanijaya, P.5
  • 2
    • 0024513175 scopus 로고
    • 1. Pettit, G. R.; Cragg, G. M.; Herald, D. L.; Schmidt, J. M.; Lohavanijaya, P. Can. J. Chem. 1982, 60, 1374. Pettit, G. R.; Singh, S. B.; Hamel, E.; Lin, C. M.; Alberts, D. S.; Garcia-Kendall, D. Experientia 1989, 45, 209. Hamel, E.; Lin, C. M. Biochem. Pharmacol. 1983, 32, 3864. Lin, C. M.; Ho, H. H.; Pettit, G. R.; Hamel, E. Biochemistry 1989, 28, 6984.
    • (1989) Experientia , vol.45 , pp. 209
    • Pettit, G.R.1    Singh, S.B.2    Hamel, E.3    Lin, C.M.4    Alberts, D.S.5    Garcia-Kendall, D.6
  • 3
    • 0021061705 scopus 로고
    • 1. Pettit, G. R.; Cragg, G. M.; Herald, D. L.; Schmidt, J. M.; Lohavanijaya, P. Can. J. Chem. 1982, 60, 1374. Pettit, G. R.; Singh, S. B.; Hamel, E.; Lin, C. M.; Alberts, D. S.; Garcia-Kendall, D. Experientia 1989, 45, 209. Hamel, E.; Lin, C. M. Biochem. Pharmacol. 1983, 32, 3864. Lin, C. M.; Ho, H. H.; Pettit, G. R.; Hamel, E. Biochemistry 1989, 28, 6984.
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 3864
    • Hamel, E.1    Lin, C.M.2
  • 4
    • 0024427745 scopus 로고
    • 1. Pettit, G. R.; Cragg, G. M.; Herald, D. L.; Schmidt, J. M.; Lohavanijaya, P. Can. J. Chem. 1982, 60, 1374. Pettit, G. R.; Singh, S. B.; Hamel, E.; Lin, C. M.; Alberts, D. S.; Garcia-Kendall, D. Experientia 1989, 45, 209. Hamel, E.; Lin, C. M. Biochem. Pharmacol. 1983, 32, 3864. Lin, C. M.; Ho, H. H.; Pettit, G. R.; Hamel, E. Biochemistry 1989, 28, 6984.
    • (1989) Biochemistry , vol.28 , pp. 6984
    • Lin, C.M.1    Ho, H.H.2    Pettit, G.R.3    Hamel, E.4
  • 5
    • 0025326011 scopus 로고
    • 2. McGown, A. T.; Fox, B. W. Cancer Chemother. Pharmacol. 1990, 26, 79. El-Zayat, A. A. E.; Degen, D.; Drabek, S.; Clark, G. M.; Pettit, G. R.; Von Hoff, D. D. Anti-Cancer Drugs 1993, 4, 19.
    • (1990) Cancer Chemother. Pharmacol. , vol.26 , pp. 79
    • McGown, A.T.1    Fox, B.W.2
  • 12
    • 85038544187 scopus 로고    scopus 로고
    • Superimposition was calculated by Molecular Modeling System SYBYL, Version 6.2; Tripos Associates, Inc.
    • 7. Superimposition was calculated by Molecular Modeling System SYBYL, Version 6.2; Tripos Associates, Inc.
  • 13
    • 0000596040 scopus 로고    scopus 로고
    • 8. Since we started this study, the synthesis of structure-restricted combretastatin analogues was reported. Shirai, R.; Okabe, T.; Iwasaki, S. Heterocycles 1997, 46, 1457.
    • (1997) Heterocycles , vol.46 , pp. 1457
    • Shirai, R.1    Okabe, T.2    Iwasaki, S.3
  • 16
    • 0001522202 scopus 로고
    • 11. Meguro, K.; Kuwada, Y. Chem. Pharm. Bull. 1973, 21, 2375. Fray, M. J.; Bull, D. J.; Cooper, K.; Parry, M. J.; Stefaniak, M. H. J. Med. Chem. 1995, 38, 3524.
    • (1973) Chem. Pharm. Bull. , vol.21 , pp. 2375
    • Meguro, K.1    Kuwada, Y.2
  • 18
    • 0021163546 scopus 로고
    • 12. Hamel, E.; Lin, C. M. Biochemistry 1984, 23, 4173. Muzaffar, A.; Brossi, A.; Lin, C. M.; Hamel, E. J. Med. Chem. 1990, 33, 567.
    • (1984) Biochemistry , vol.23 , pp. 4173
    • Hamel, E.1    Lin, C.M.2
  • 21
    • 0002832133 scopus 로고
    • 13. Alley, M. C.; Scudiero, D. A.; Monks, A.; Hursey, M. L.; Czerwinski, M. J.; Fine, D. L.; Abbott, B. J.; Mayo, J. G.; Shoemaker, R. H.; Boyd, M. R. Cancer Res. 1988, 48, 589. Mossman, T. J. Immunol. Meth. 1983, 65, 55.
    • (1983) J. Immunol. Meth. , vol.65 , pp. 55
    • Mossman, T.1
  • 22
    • 85038551443 scopus 로고    scopus 로고
    • note
    • 14. Fragments of colon 26 tumor (5mg) were inoculated sc into CD2F1 mice. Test compounds were given iv or sc on days 7, 11 and 15. On day 21, the tumor weights were measured. The inhibition ratio was evaluated as (1-T/C)X100 (%) (T; the mean tumor weight of the treated group, C; the mean tumor weight of the control group). Each group consisted of 5 mice.


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