Synthesis and evaluation of double bond substituted combretastatins

European Journal of Medicinal Chemistry

Volumn 40, Issue 6, 2005, Pages 529-541

  Hadfield, John A ^a,b   Gaukroger, Keira ^b   Hirst, Nicholas ^a   Weston, Anna P ^a   Lawrence, Nicholas J ^c,d   McGown, Alan T ^a,b  

^a UNIVERSITY OF SALFORD   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Antimitotic; Combretastatin; Tubulin

Indexed keywords

2 (3',4',5' TRIMETHOXYPHENYL) 3 (3'' HYDROXY 4'' METHOXYPHENYL)PROP 2 ENE; 3 (3',4',5' TRIMETHOXYPHENYL) 4 (3'' HYDROXY 4'' METHOXYPHENYL)BUT 3 ENE; COMBRETASTATIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CYTOTOXICITY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MICROTUBULE ASSEMBLY; MITOSIS;

AMIDES; ANTINEOPLASTIC AGENTS; BIBENZYLS; CELL CYCLE; CELL SURVIVAL; EPOXY COMPOUNDS; FORMAZANS; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; SPECTROPHOTOMETRY, ULTRAVIOLET; STILBENES; TETRAZOLIUM SALTS; TUBULIN; TUBULIN MODULATORS;

EID: 19544367790     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.12.008     Document Type: Article

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