Conformationally restricted anti-plasmodial chalcones

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 21, 2005, Pages 4858-4861

  Larsen, Mogens ^a,b   Kromann, Hasse ^a,c   Kharazmi, Arsalan ^a   Nielsen, Simon Feldbæk ^a,d  

^a Lica Pharmaceuticals A/S   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c MedChem Aps   (Denmark)

^d LEO PHARMA A S   (Denmark)

Author keywords

Chalcone isomers; Malaria

Indexed keywords

CHALCONE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; ISOMER; NONHUMAN; PLASMODIUM;

ANIMALS; ANTIMALARIALS; CHALCONES; MOLECULAR CONFORMATION; PLASMODIUM FALCIPARUM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 25144501143     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.07.012     Document Type: Article

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31. 3): δ = 7.74 (d, J = 6.9 Hz, 2H), 7.41-7.32 (m, 1H), 30-7.20 (m, 2H), 7.18-7.05 (m, 5H), 3.08-2.86 (m, 4H), 2.20-2.05 unitet, 2H.
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34. 3): δ 7.66 (d, J = 9.0 Hz, 2H), 6.95 (d, J = 8.4 Hz, 1H), 6.90 (d, J = 8.8 Hz, 2H), 6.71 (d, J = 1.3 Hz, 1H), 6.43 (dd, J = 8.4 Hz, J = 2.5 Hz, 1H), 6.39 (d, J = 1.8 Hz, 1H), 5.06 (d, J = 1.4 Hz, 2H), 3.82 (s, 3H), 3.74 (s, 3H).
35. 3): δ 7.64 (2H, d, J = 8.3 Hz), 7.34 (1H, dd, J = 8.1 Hz, 2.4 Hz), 7.30 (2H, d, J = 8.3 Hz), 7.22 (1H, d, J = 2.4 Hz), 7.03 (1H, br s), 6.79 (1H, d, J = 8.1 Hz) 5.18 (2H, br s), 2.42 (3H, s).
36. 3): δ 7.39 (1H, td, J = 7.4 Hz, 1.8 Hz), 7.33 (1H, dd, J = 8.8 Hz, 2.6 Hz), 7.30-7.23 (3H, m), 7.17 (1H, d, J = 2.6 Hz), 6.82 (1H, br s), 6.77 (1H, dd, J = 8.6 Hz, 0.6 Hz), 5.19 (2H, s), 2.36 (3H, s).
37. 3): δ 7.38 (1H, td, J = 7.5 Hz, 1.6 Hz), 7.31 (1H, dd, J = 7.5 Hz, 1.6 Hz), 7.30-7.22 (2H, m), 6.92-6.90 (2H, m), 6.86 (1H, t, J = 7.5 Hz), 6.68 (1H, dd, J = 7.5 Hz, 1.5 Hz), 5.15 (2H, s), 3.90 (3H, s), 2.38 (3H, s).
38. 3): δ 7.72 (1H, d, J = 16.3 Hz), 7.67 (1H, d, J = 2.6 Hz), 7.51 (1H, dd, J = 8.2 Hz, 1.6 Hz), 7.45 (1H, dd, J = 8.8 Hz, 2.6 Hz), 7.38 (1H, td, J = 7.3 Hz, 1.6 Hz), 7.3-7.24 (m, 2H), 7.20 (1H, d, J = 16.3 Hz), 6.82 (1H, d, J = 8.8 Hz) 3.82 (3H, s), 2.41 (3H, s).
39. 3): δ 7.81 (1H, d, J = 16.1 Hz), 7.81 (1H, bd, J ≈ 8 Hz), 7.32 (1H, td, J = 7.9, 1.8 Hz), 7.30-7.20 (3H, m), 7.18 (1H, d, J = 16.1 Hz), 7.08 (1H, t, J = 7.9 Hz), 6.96 (1H, dd, J = 8.0, 1.3 Hz), 3.87 (3H, s), 3.82 (3H, s), 2.46 (3H, s).
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