Genetically modified plants and food hypersensitivity diseases: Usage and implications of experimental models for risk assessment

Pharmacology and Therapeutics

Volumn 111, Issue 2, 2006, Pages 374-383

  Prescott, Vanessa E ^a   Hogan, Simon P ^b  

^a Biology and Environment   (Australia)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Animal model; Assessment; Decision tree; Food allergy; Genetically modified plants; Regulatory T cells

Indexed keywords

ALBUMIN; AMYLASE INHIBITOR;

ALLERGENICITY; ALLERGIC DISEASE; ALLERGY; ANTIGENICITY; CELLULAR IMMUNITY; DOG; EXPERIMENTAL MODEL; FOOD ALLERGY; FOOD SAFETY; GENETICALLY MODIFIED CROP; GENETICALLY MODIFIED FOOD; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATION; LUPIN; MOUSE STRAIN; NONHUMAN; PEA; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT STRAIN; REVIEW; RISK ASSESSMENT; SUNFLOWER; SWINE; TH1 CELL;

ANIMALS; DISEASE MODELS, ANIMAL; FOOD HYPERSENSITIVITY; FOOD, GENETICALLY MODIFIED; HUMANS; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; RISK ASSESSMENT;

EID: 33744798003     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2005.10.005     Document Type: Review

References (78)

1. Alinorm 03/34: Joint FAO/WHO Food Standard Programme. C. A. C.: Appendix III: Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants; and Appendix IV: Annex on the assessment of possible allergenicity (2003, June 30-July 5), Codex Alimentarius Commission, Rome, Italy 47-60
2. Atherton K.T., Dearman R.J., and Kimber I. Protein allergenicity in mice: a potential approach for hazard identification. Ann NY Acad Sci 964 (2002) 163-171
3. Baur X., and Czuppon A.B. Allergic reaction after eating α-amylase (ASp o 2)-containing bread. A case report. Allergy 50 (1995) 85-87
4. Baur X., and Posch A. Characterized allergens causing bakers' asthma. Allergy 53 (1998) 562-566
5. Brandt P. Overview of the current status of genetically modified plants in Europe as compared to the USA. J Plant Physiol 160 (2003) 735-742
6. Brandt E.B., Strait R.T., Hershko D., Wang Q., Muntel E.E., Scribner T.A., et al. Mast cells are required for experimental oral allergen-induced diarrhea. J Clin Invest 112 (2003) 1666-1677
7. Brandtzaeg P.E. Current understanding of gastrointestinal immunoregulation and its relation to food allergy. Ann NY Acad Sci 964 (2002) 13-45
8. Buchanan B.B., and Frick O.L. The dog as a model for food allergy. Ann NY Acad Sci 964 (2002) 173-183
9. Buchanan B.B., Adamidi C., Lozano R.M., Yee B.C., Momma M., Kobrehel K., et al. Thioredoxin-linked mitigation of allergic responses to wheat. Proc Natl Acad Sci U S A 94 (1997) 5372-5377
10. Burks W. Current understanding of food allergy. Ann NY Acad Sci 964 (2002) 1-12
11. Chehade M., and Mayer L. Oral tolerance and its relation to food hypersensitivities. J Allergy Clin Immunol 115 (2005) 3-12
12. Cohn L., Homer R.J., Niu N., and Bottomly K. T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production. J Exp Med 190 (1999) 1309-1318
13. Conner A.J., Glare T.R., and Nap J.P. The release of genetically modified crops into the environment: Part II. Overview of ecological risk assessment. Plant J 33 (2003) 19-46
14. Dearman R.J., and Kimber I. Determination of protein allergenicity: studies in mice. Toxicol Lett 120 (2001) 181-186
15. Dearman R.J., Caddick H., Basketter D.A., and Kimber I. Divergent antibody isotype responses induced in mice by systemic exposure to proteins: a comparison of ovalbumin with bovine serum albumin. Food Chem Toxicol 38 (2000) 351-360
16. Dearman R.J., Caddick H., Stone S., Basketter D.A., and Kimber I. Characterization of antibody responses induced in rodents by exposure to food proteins: influence of route of exposure. Toxicology 167 (2001) 217-231
17. Eigenmann P.A. T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells. Pediatr Allergy Immunol 13 (2002) 162-171
18. Engel K.H., Frenzel T., and Miller A. Current and future benefits from the use of GM technology in food production. Toxicol Lett 127 (2002) 329-336
19. Faye L., Gomord V., Fitchette-Laine A.C., and Chrispeels M.J. Affinity purification of antibodies specific for Asn-linked glycans containing a1-3 fucose or b1-2 xylose. Anal Biochem 209 (1993) 104-108
20. Goodman R.E., Hefle S.L., Taylor S.L., and van Ree R. Assessing genetically modified crops to minimize the risk of increased food allergy: a review. Int Arch Allergy Immunol 137 (2005) 153-166
21. Helm R.M., and Burks A.W. Animal models of food allergy. Curr Opin Allergy Clin Immunol 2 (2002) 541-546
22. Helm R.M., Furuta G.T., Stanley J.S., Ye J., Cockrell G., Connaughton C., et al. A neonatal swine model for peanut allergy. J Allergy Clin Immunol 109 (2002) 136-142
23. Helm R.M., Ermel R.W., and Frick O.L. Nonmurine animal models of food allergy. Environ Health Perspect 111 (2003) 239-244
24. Hoffman L.M., Ma Y., and Barker R.F. Molecular cloning of Phaseolus vulgaris lectin mRNA and use of cDNA as a probe to estimate lectin transcript levels in various tissues. Nucleic Acids Res 10 (1982) 7819-7828
25. Hogan S., Foster P., Tan X., and Ramsay A. Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity. Eur J Immunol 28 (1998) 413-423
26. Hogan S.P., Mishra A., Brandt E.B., Royalty M.P., Pope S.M., Zimmermann N., et al. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol 2 (2001) 353-360
27. Ishimoto M., Suzuki K., Iwanaga M., Kikuchi F., and Kitamura I. Variation of seed α-amylase inhibitors in the common bean. Theor Appl Genet 90 (1995) 425-429
28. Kanny G., and Moneret-Vautrin D.A. α-Amylase contained in bread can induce food allergy. J Allergy Clin Immunol 95 (1995) 132-133
29. Kelly K.J. Eosinophilic gastroenteritis. J Pediatr Gastroenterol Nutr 30 Suppl. (2000) S28-S35
30. Kelly J.D., Hlywka J.J., and Hefle S.L. Identification of sunflower seed IgE-binding proteins. Int Arch Allergy Immunol 121 (2000) 19-24
31. Khakoo A., and Lack G. Preventing food allergy. Curr Allergy Asthma Rep 4 (2004) 36-42
32. Knippels L.M., and Penninks A.H. Assessment of protein allergenicity: studies in Brown Norway rats. Ann NY Acad Sci 964 (2002) 151-161
33. Knippels L.M., Penninks A.H., Spanhaak S., and Houben G.F. Oral sensitization to food proteins: a Brown Norway rat model. Clin Exp Allergy 28 (1998) 368-375
34. Lee H.O., Miller S.D., Hurst S.D., Tan L.J., Cooper C.J., and Barrett T.A. Interferon gamma induction during oral tolerance reduces T-cell migration to sites of inflammation. Gastroenterology 119 (2000) 129-138
35. Li X.M., Serebrisky D., Lee S.Y., Huang C.K., Bardina L., Schofield B.H., et al. A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J Allergy Clin Immunol 106 (2000) 150-158
36. Lorentz A., Schwengberg S., Mierke C., Manns M.P., and Bischoff S.C. Human intestinal mast cells produce IL-5 in vitro upon IgE receptor cross-linking and in vivo in the course of intestinal inflammatory disease. Eur J Immunol 29 (1999) 1496-1503
37. Martin Young N., Thibault P., Watson D.C., and Chrispeels M.J. Post-translational processing of two α-amylase inhibitors and an arcelin from the common bean, Phaseolus vulgaris. FEBS Lett 446 (1999) 203-206
38. Mason H.S., Warzecha H., Mor T., and Arntzen C.J. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol Med 8 (2002) 324-329
39. Metcalfe D.D., Astwood J.D., Townsend R., Sampson H.A., Taylor S.L., and Fuchs R.L. Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit Rev Food Sci Nutr 36 Suppl. (1996) S165-S186
40. Miller S.D., and Hanson D.G. Inhibition of specific immune responses by feeding protein antigens: IV. Evidence for tolerance and specific active suppression of cell mediated immune responses to ovalbumin. J Immunol 123 (1979) 2344
41. Molvig L., Tabe L.M., Eggum B.O., Moore A.E., Craig S., Spencer D., et al. Enhanced methionine levels and increased nutritive value of seeds of transgenic lupins (Lupinus angustifolius L.) expressing a sunflower seed albumin gene. Proc Natl Acad Sci U S A 94 (1997) 8393-8398
42. Morton R.L., Schroeder H.E., Bateman K.S., Chrispeels M.J., Armstrong E., and Higgins T.J. Bean alpha-amylase inhibitor 1 in transgenic peas (Pisum sativum) provides complete protection from pea weevil (Bruchus pisorum) under field conditions. Proc Natl Acad Sci U S A 97 (2000) 3820-3825
43. Mowat A.M. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 3 (2003) 331-341
44. Mowat A.M., Strobel S., Drummond H.E., and Ferguson A. Immunological responses to fed protein antigens in mice: I. Reversal of oral tolerance to ovalbumin by cyclophosphamide. Immunology 45 (1982) 105-113
45. Nagata S., McKenzie C., Pender S.L., Bajaj-Elliott M., Fairclough P.D., Walker-Smith J.A., et al. Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile. J Immunol 165 (2000) 5315-5321
46. Ngan J., and Kind L.S. Suppressor T cell for IgE and IgG in Peyer's patches of mice made tolerant by the oral administration of ovalbumin. J Immunol 120 (1978) 861-868
47. Nordlee J.A., Taylor S.L., Townsend J.A., Thomas L.A., and Bush R.K. Identification of a Brazil-nut allergen in transgenic soybeans. N Engl J Med 334 (1996) 688-692
48. Novak W.K., and Haslberger A.G. Substantial equivalence of antinutrients and inherent plant toxins in genetically modified novel foods. Food Chem Toxicol 38 (2000) 473-483
49. Oehlschlager S., Reece P., Brown A., Hughson E., Hird H., Chisholm J., et al. Food allergy-towards predictive testing for novel foods. Food Addit Contam 18 (2001) 1099-1107
50. Okano M., Nishizaki K., Abe M., Wang M.M., Yoshino T., Satoskar A.R., et al. Strain-dependent induction of allergic rhinitis without adjuvant in mice. Allergy 54 (1999) 593-601
51. Penninks A.H., and Knippels L.M. Determination of protein allergenicity: studies in rats. Toxicol Lett 120 (2001) 171-180
52. Prescott V.E., Campbell P.M., Mattes J., Rothenberg M.E., Foster P.S., and H. T. J. V. Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity. J Agric Food Chem 53 23 (2005) 9023-9030
53. Read S., and Powrie F. CD4+ regulatory T cells. Curr Opin Immunol 13 (2001) 644-649
54. Rothenberg M.E. Eosinophilia. N Engl J Med 338 (1998) 1592-1600
55. Russo M., Nahori M.A., Lefort J., Gomes E., de Castro Keller A., Rodriguez D., et al. Suppression of asthma-like responses in different mouse strains by oral tolerance. Am J Respir Cell Mol Biol 24 (2001) 518-526
56. Sampson H.A. Food allergy: Part 1. Immunopathogenesis and clinical disorders. J Allergy Clin Immunol 103 (1999) 717-728
57. Sampson H.A. Food allergy. J Allergy Clin Immunol 111 (2003) S540-S547
58. Sanchez-Monge R., Gomez L., Barber D., Lopez-Otin C., Armentia A., and Salcedo G. Wheat and barley allergens associated with baker's asthma. Glycosylated subunits of the alpha-amylase-inhibitor family have enhanced IgE-binding capacity. Biochem J 281 Pt 2 (1992) 401-405
59. Santos J., Bayarri C., Saperas E., Nogueiras C., Antolin M., Mourelle M., et al. Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy. Gut 45 (1999) 553-558
60. Sawada S., Takeda Y., and Tashiro M. primary structures of alpha- and beta-subunits of alpha-amylase inhibitors from seeds of three cultivars of phaseolus beans. J Protein Chem 21 (2002) 9-17
61. Schroeder H.E., Gollasch S., Moore A.E., Tabe L.M., Craig S., Hardie D.C., et al. Bean α-amylase inhibitor confers resistance to the pea weevil (Bruchus pisorum) in transgenic peas (Pisum sativum L.). Plant Physiol 107 (1995) 1233-1239
62. Sicherer S.H. Food allergy. Lancet 360 (2002) 701-710
63. Siddiqui A.A., and Miner P.B. The role of mast cells in common gastrointestinal diseases. Curr Allergy Asthma Rep 4 (2004) 47-54
64. Smart V., Foster P.S., Rothenberg M.E., Higgins T.J., and Hogan S.P. A plant-based allergy vaccine suppresses experimental asthma via an IFN-gamma and CD4(+)CD45RB(low) T cell-dependent mechanism. J Immunol 171 (2003) 2116-2126
65. Stewart, Jr., C. N., Richards, H. A. t., & Halfhill, M. D. (2000). Transgenic plants and biosafety: science, misconceptions and public perceptions. Biotechniques, 29, 832-836, 838-843.
66. Strobel S., Mowat A.M., Drummond H.E., Pickering M.G., and Ferguson A. Immunological responses to fed protein antigens in mice: II. Oral tolerance for CMI is due to activation of cyclophosphamide-sensitive cells by gut-processed antigen. Immunology 49 (1983) 451-456
67. Taylor S.L. Protein allergenicity assessment of foods produced through agricultural biotechnology. Annu Rev Pharmacol Toxicol 42 (2002) 99-112
68. Taylor S.L., and Hefle S.L. Genetically engineered foods: implications for food allergy. Curr Opin Allergy Clin Immunol 2 (2002) 249-252
69. Tryphonas H., Arvanitakis G., Vavasour E., and Bondy G. Animal models to detect allergenicity to foods and genetically modified products: workshop summary. Environ Health Perspect 111 (2003) 221-222
70. Turcanu V., Maleki S.J., and Lack G. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest 111 (2003) 1065-1072
71. Untersmayr E., Scholl I., Swoboda I., Beil W.J., Forster-Waldl E., Walter F., et al. Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice. J Allergy Clin Immunol 112 (2003) 616-623
72. Van Ree R., Cabanes-Macheteau M., Akkerdaas J., Milazzo J., Loutelier-Bourhis C., Rayon C., et al. b(1,2)-xylose and a(1,3)-fucose residues have a string contriubtion in IgE binding to plant glycoallergens. J Biol Chem 275 (2000) 11451-11458
73. Weiner H.L. Oral tolerance, an active immunologic process mediated by multiple mechanisms. J Clin Invest 106 (2000) 935-937
74. Whitacre C.C., Gienapp I.E., Orosz C.G., and Bitar D.M. Oral tolerance in experimental autoimmune encephalomyelitis. Eur J Immunol 147 (1991) 2155-2163
75. Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 17 (1999) 255-281
76. Wills-Karp M. Murine models of asthma in understanding immune dysregulation in human asthma. Immunopharmacology 48 (2000) 263-268
77. Yamaguchi H., Funaoka H., and Iwamoto H. Structures of sugar chains of the subunits of an alpha-amylase inhibitor from Phaseolus vulgaris white kidney beans. J Biochem (Tokyo) 111 (1992) 388-395
78. Yu L.C., and Perdue M.H. Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress. Immunol Rev 179 (2001) 61-73