Mutational biosynthesis - A tool for the generation of structural diversity in the biosynthesis of antibiotics

Applied Microbiology and Biotechnology

Volumn 68, Issue 2, 2005, Pages 141-150

  Weist, S ^a,b   Sussmuth R D ^a  

^a TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOTECHNOLOGY; METABOLITES; MICROORGANISMS; MOLECULAR BIOLOGY; ONCOLOGY; SYNTHESIS (CHEMICAL);

CANCER THERAPY; MUTASYNTHESIS; MUTATIONAL BIOSYNTHESIS; STRUCTURAL DIVERSITY;

BIOSYNTHESIS;

2 DEOXYSTREPTAMINE; 2 EPISTREPTAMINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; AVERMECTIN; BALHIMYCIN; BUTIROSIN; CLOROBIOCIN; COUMAMYCIN; DORAMECTIN; ENTEROCIN; ERYTHROMYCIN; FLUOROBALHIMYCIN; HYBRIMYCIN; MACROLIDE; METHYLPYOCHELIN; MICRONOMICIN; NEOMYCIN; NIKKOMYCIN; NIKKOMYCIN X; NIKKOMYCIN Z; NOVOBIOCIN; POLYPEPTIDE ANTIBIOTIC AGENT; PYOCHELIN; RAPAMYCIN; SIDEROPHORE; TACROLIMUS; UNCLASSIFIED DRUG; VANCOMYCIN; VULGAMYCIN; WAILUPEMYCIN;

ANTIBIOTICS;

BACTERIUM; CANCER CHEMOTHERAPY; COMPLEX FORMATION; DELETION MUTANT; DRUG DISTRIBUTION; DRUG RESEARCH; DRUG SAFETY; DRUG SYNTHESIS; DRUG UPTAKE; EXPECTATION; FUNGUS; GENE LIBRARY; GENETIC VARIABILITY; HUMAN; MEDICAL TECHNOLOGY; MOLECULAR EVOLUTION; NONHUMAN; PHYSICAL CHEMISTRY; PRECURSOR; SHORT SURVEY; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

ACTINOBACTERIA; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIA; CULTURE MEDIA; MACROLIDES; MUTATION; NEOMYCIN; NOVOBIOCIN; PEPTIDES; SIDEROPHORES; STREPTOMYCES;

FUNGI;

EID: 23444460405     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-005-1891-8     Document Type: Short Survey

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