Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations

Biochemistry

Volumn 45, Issue 20, 2006, Pages 6341-6353

  Pearson, Josh T ^a   Hill, John J ^b   Swank, Jennifer ^b   Isoherranen, Nina ^a   Kunze, Kent L ^a   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; COMPLEXATION; CYTOLOGY; ENZYME INHIBITION; NITROGEN; SURFACE PLASMON RESONANCE;

CYTOCHROME P450S (CYP); ITRACONAZOLE (ITZ); KETOCONAZOLE (KTZ);

DRUG PRODUCTS;

ANTIFUNGAL AGENT; COMPLEMENTARY DNA; CYTOCHROME P450 3A4; GLYCEROL; ITRACONAZOLE; KETOCONAZOLE; LIGAND; METHANOL; MIDAZOLAM; POTASSIUM DIHYDROGEN PHOSPHATE; TESTOSTERONE;

ARTICLE; BINDING KINETICS; CHEMICAL STRUCTURE; DRUG CLEARANCE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; ENANTIOMER; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SURFACE PLASMON RESONANCE;

ANTIFUNGAL AGENTS; BINDING SITES; CYTOCHROME P-450 CYP3A; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; ITRACONAZOLE; KETOCONAZOLE; KINETICS; LIGHT; PROTEIN CONFORMATION; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; SURFACE PLASMON RESONANCE;

EID: 33646874799     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0600042     Document Type: Article

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