Atypical enzyme kinetics: Their effect on in vitro-in vivo pharmacokinetic predictions and drug interactions

Current Drug Metabolism

Volumn 4, Issue 5, 2003, Pages 341-346

  Tracy, Timothy S ^a,b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Atypical kinetics; Clearance; Cytochrome P450; Drug interactions; In vitro in vivo correlations; Pharmacokinetics

Indexed keywords

CARBAMAZEPINE; CYTOCHROME P450; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DAPSONE; DICLOFENAC; FELBAMATE; FLURBIPROFEN; ISOENZYME; ISRADIPINE; MIBEFRADIL; MIDAZOLAM; NAPROXEN; NIFEDIPINE; PIROXICAM; QUINIDINE; TERFENADINE; TESTOSTERONE; TRIAZOLAM;

CALCULATION; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; MICHAELIS MENTEN KINETICS; NONHUMAN; OBSERVATION; PREDICTION; REVIEW; STANDARD;

ALGORITHMS; ANIMALS; DRUG INTERACTIONS; ENZYMES; HUMANS; PHARMACOKINETICS; PREDICTIVE VALUE OF TESTS;

EID: 0142106309     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200033489280     Document Type: Review

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