Intramolecular isotope effects for benzylic hydroxylation of isomeric xylenes and 4,4'-dimethylbiphenyl by cytochrome P450: Relationship between distance of methyl groups and masking of the intrinsic isotope effect

Biochemistry

Volumn 36, Issue 23, 1997, Pages 7136-7143

  Iyer, Krishna R ^a   Jones, Jeffrey P ^b   Darbyshire, John F ^a   Trager, William F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' DIMETHYLBIPHENYL; BIPHENYL DERIVATIVE; CYTOCHROME P450; UNCLASSIFIED DRUG; XYLENE;

ANIMAL CELL; ARTICLE; CATALYSIS; ENZYME MECHANISM; HYDROXYLATION; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BENZENE; BIPHENYL COMPOUNDS; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; HYDROGEN BONDING; HYDROXYLATION; ISOMERISM; KINETICS; MALE; METHYLATION; MICROSOMES, LIVER; MODELS, CHEMICAL; RATS; RATS, SPRAGUE-DAWLEY; XYLENES;

ANIMALIA;

EID: 0030910832     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962810m     Document Type: Article

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