Structural diversities of active site in clinical azole-bound forms between sterol 14α-demethylases (CYP51s) from human and Mycobacterium tuberculosis

Journal of Biological Chemistry

Volumn 280, Issue 10, 2005, Pages 9088-9096

  Matsuura, Koji ^a,e   Yoshioka, Shiro ^b   Tosha, Takehiko ^c   Hori, Hiroshi ^d   Ishimori, Koichiro ^a   Kitagawa, Teizo ^c   Morishima, Isao ^a   Kagawa, Norio ^b   Waterman, Michael R ^b  

^a KYOTO UNIVERSITY   (Japan)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTES OF NATURAL SCIENCES   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; AMINO ACIDS; BACTERIA; HYDROPHOBICITY; PIGMENTS; RAMAN SPECTROSCOPY; TITRATION;

BINDING PROPERTIES; CYTOCHROMES; MYCOBACTERIUM TUBERCULOSIS; SELECTIVE AZOLE ANTI-FUNGALS;

ENZYMES;

4 PHENYLIMIDAZOLE; FLUCONAZOLE; KETOCONAZOLE; PYRROLE; STEROL 14ALPHA DEMETHYLASE; VINYL DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; HUMAN; LIPOPHILICITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SPECTROSCOPY; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; AZOLES; BACTERIAL PROTEINS; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; HEME; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY; SPECTRUM ANALYSIS, RAMAN;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 15744390565     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413042200     Document Type: Article

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