The role of nuclear factor kappa B activation in atherosclerosis and ischemic cardiac injury

Korean Circulation Journal

Volumn 36, Issue 4, 2006, Pages 245-251

  Ahn, Youngkeun ^a   Kim, Yong Sook ^a   Jeong, Myung Ho ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

Atherosclerosis; NF B

Indexed keywords

ACETYLSALICYLIC ACID; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN; PROTEIN P50; PROTEIN P52; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA;

ACUTE CORONARY SYNDROME; APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROSIS; CELL SURVIVAL; DRUG INHIBITION; GENE INDUCTION; HEART INJURY; HUMAN; INFLAMMATION; ISCHEMIC HEART DISEASE; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 33646472330     PISSN: 17385520     EISSN: 17385555     Source Type: Journal    
DOI: 10.4070/kcj.2006.36.4.245     Document Type: Review

References (86)

1. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999;340:115-26.
2. Shah PK. Plaque disruption and thrombosis: potential role of inflammation and infection. Cardiol Rev 2000;8:31-9.
3. Buffon A, Biasucci LM, Liuzzo G, D'Onofrio G, Crea F, Maseri A. Widespread coronary inflammation in unstable angina. N Engl J Med 2002;347:5-12.
4. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336:1066-71.
5. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002;3:221-7.
6. Ahn Y, Kim YS, Park HW, et al. In vivo cardiac gene transfer of dominant negative IKK-β reduces myocardial inflammation, apoptosis, and infarction after ischemia-reperfusion injury. Korean Circ J 2005; 35:206-14.
7. Collins T, Cybulsky MI. NF-kappa B: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest 2001;107:255-64.
8. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive Ikappa B kinase that activates the transcription factor NF-kappa B. Nature 1997;388:548-54.
9. Mercuric F, Zhu H, Murray BW, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 1997;278:860-6.
10. Hu Y, Baud V, Delhase M, et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of Ikappa B kinase. Science 1999;284:316-20.
11. Senftleben U, Cao Y, Xiao G, et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001;293:1495-9.
12. Li Q, van Antwerp D, Mercurio F, Lee KF, Verma IM. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999;284:321-5.
13. Meiler SE, Hung RR, Gerszten RE, et al. Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions. J Mol Cell Cardiol 2002;34:349-59.
14. Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 2000;20:1626-38.
15. Imbert V, Rupec RA, Livolsi A, et al. Tyrosine phosphorylation of Ikappa B-alpha activates NF-kappa B without proteolytic degradation of Ikappa B-alpha. Cell 1996;86:787-98.
16. Chen L, Fischle W, Verdin E, Greene WC. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 2001;293:1653-7.
17. Krikos A, Laherty CD, Dixit VM. Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J Biol Chem 1992;267:17971-6.
18. Opipari AW Jr, Boguski MS, Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem 1990;265:14705-8.
19. Lee EG, Boone DL, Chai S, et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000;289:2350-4.
20. Opipari AW Jr, Hu HM, Yabkowitz R, Dixit VM. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem 1992;267:12424-7.
21. Hu X, Yee E, Harlan JM, Wong F, Karsan A. Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells. Blood 1998;92:2759-65.
22. He KL, Ting AT. A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol Cell Biol 2002;22:6034-45.
23. Lusis AJ. Atherosclerosis. Nature 2000;407:233-41.
24. Kim YS, Ahn Y, Hong MH, et al. Carvedilol inhibits expressions of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, monocyte chemoattractant-l, and interleukin-8 via NF- κB inhibition in human endothelial cells. Korean Circ J 2005;35: 576-82.
25. Park SW, Seo HS, Kim JW, et al. Effect of human bcl-2 gene expression on the peripheral atherosclerotic lesions of apolipoprotein E-deficient mouse. Korean Circ J 2005;35:725-33.
26. Goldstein JA, Demetriou D, Grines CL, Pica M, Shoukfeh M, O'Neill WW. Multiple complex coronary plaques in patients with acute myocardial infarction. N Engl J Med 2000;343:915-22.
27. Rioufol G, Finet G, Ginon I, et al. Multiple atherosclerotic plaque rupture in acute coronary syndrome: a three-vessel intravascular ultrasound study. Circulation 2002;106:804-8.
28. Thurberg BL, Collins T. The nuclear factor-kappa B/inhibitor of kappa B autoregulatory system and atherosclerosis. Curr Opin Lipidol 1998;9:387-96.
29. Rajavashisth TB, Xu XP, Jovinge S, et al. Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators. Circulation 1999;99:3103-9.
30. Galis ZS, Sukhova GK, Kranzhofer R, Clark S, Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci USA 1995; 92:402-6.
31. Taubman MB, Fallon JT, Scheeler AD, et al. Tissue factor in the pathogenesis of atherosclerosis. Thromb Haemost 1997;78:200-4.
32. Scheeler AD, Rollins BJ, Zhang YJ, et al. Tissue factor is induced by monocyte chemoattractant protein-1 in human aortic smooth muscle and THP-1 cells. J Biol Chem 1997;272:28568-73.
33. Smith JD, Trogan E, Ginsberg M, Grigaux C, Tian J, Miyata M. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci USA 1995;92:8264-8.
34. Gu L, Okada Y, Clinton SK, et al. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 1998;2:275-81.
35. Boring L, Gosling J, Cleary M, Charo IF. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 1998;394:894-7.
36. Moreno PR, Falk E, Palacios IF, Newell JB, Fuster V, Fallon JT Macrophage infiltration in acute coronary syndromes: implications for plaque rupture. Circulation 1994;90:775-8.
37. Jiang Y, Zhu JF, Luscinskas FW, Graves DT. MCP-1-stimulated monocyte attachment to laminin is mediated by beta 2-integrins. Am J Physiol 1994;267:C1112-8.
38. Weber C, Alon R, Moser B, Springer TA. Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis. J Cell Biol 1996;134:1063-73.
39. Gerszten RE, Garcia-Zepeda EA, Lim YC, et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999;398:718-23.
40. Luscinskas FW, Ding H, Tan P, Cumming D, Tedder T, Gerritsen ME. L-and P-selectins, but not CD49d (VLA4) integrins, mediate monocyte initial attachment to TNF-activated vascular endothelium in vitro. J Immunol 1996;157:326-35.
41. Ramos CL, Huo Y, Jung U, et al. Direct demonstration of P-selectin-and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E- deficient mice. Circ Res 1999;84:1237-44.
42. Luscinskas FW, Kansas GS, Ding H, et al. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J Cell Biol 1994;125:1417-27.
43. Gerszten RE, Lim YC, Ding HT, et al. Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis. Circ Res 1998;82:871-8.
44. Hajra L, Evans AI, Chen M, Hyduk SJ, Collins T, Cybulsky MI. The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Proc Natl Acad Sci USA 2000;97: 9052-7.
45. Ritchie ME. Nuclear factor-kappaB is selectively and markedly activated in humans with unstable angina pectoris. Circulation 1998;98:1707-13.
46. Jude B, Agraou B, McFadden EP, et al. Evidence for time-dependent activation of monocytes in the systemic circulation in unstable angina but not in acute myocardial infarction or in stable angina. Circulation 1994;90:1662-8.
47. Read MA, Whitley MZ, Gupta S, et al. Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways. J Biol Chem 1997;272:2753-61.
48. Zen K, Karsan A, Stempien-Otero A, et al. NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide. J Biol Chem 1999;274:28808-15.
49. Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med 1998;188: 211-6.
50. Pasternak R, Braunwald E, Sobel B. Acute myocardial infarction. In: Braunwald E, editor. Heart Disease. 4th ed. Philadelphis: W.B. Sounders Company; 1992. p. 1200-91.
51. Ma XL, Weyrich AS, Lefer DJ, et al. Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. Circulation 1993;88:649-58.
52. Herskowitz A, Choi S, Ansari AA, Wesselingh S. Cytokine mRNA expression in postischemic/reperfused myocardium. Am J Pathol 1995;146:419-28.
53. Gurevitch J, Frolkis I, Yuhas Y, et al. Tumor necrosis factor-alpha is released from the isolated heart undergoing ischemia and reperfusion. J Am Coll Cardiol 1996;28:247-52.
54. Massey KD, Strieter RM, Kunkel SL, Danforth JM, Standiford TJ. Cardiac myocytes release leukocyte-stimulating factors. Am J Physiol 1995;269:H980-7.
55. O'Neill CA, Fu LW, Halliwell B, Longhurst JC. Hydroxyl radical production during myocardial ischemia and reperfusion in cats. Am J Physiol 1996;271:H660-7.
56. Albertine KH, Weyrich AS, Ma XL, Lefer DJ, Becker LC, Lefer AM. Quantification of neutrophil migration following myocardial ischemia and reperfusion in cats and dogs. J Leukoc Biol 1994; 55:557-66.
57. Xia Y, Zweier JL. Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J Biol Chem 1995; 270:18797-803.
58. Slezak J, Tribulova N, Pristacova J, et al. Hydrogen peroxide changes in ischemic and reperfused heart: cytochemistry and biochemical andX-ray microanalysis. Am J Pathol 1995;147:772-81.
59. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, Engler RL. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 1994;94:1621-8.
60. Buerke M, Murohara T, Skurk C, Nuss C, Tomaselli K, Lefer AM. Cardioprotective effect of insulin-like growth factor 1 in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci USA 1995;92:8031-5.
61. Romson JL, Hook BG, Kunkel SL, Abrams GD, Schork MA, Lucchesi BR. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation 1983;67: 1016-23.
62. Mullane KM, Read N, Salmon JA, Moncada S. Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs. J Pharmacol Exp Ther 1984;228:510-22.
63. Engler RL, Dahlgren MD, Morris DD, Peterson MA, Schmid-Schonbein GW. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol 1986;251:H314-23.
64. Tanaka M, Brooks SE, Richard VJ, et al. Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs. Circulation 1993;87: 526-35.
65. Maroko PR, Carpenter CB, Chiariello M, et al. Reduction by cobra venom factor of myocardial necrosis after coronary artery occlusion. J Clin Invest 1978;61:661-70.
66. Shappell SB, Taylor AA, Hughes H, Mitchell JR, Anderson DC, Smith CW. Comparison of antioxidant and nonantioxidant lipoxygenase inhibitors on neutrophil function: implications for pathogenesis of myocardial reperfusion injury. J Pharmacol Exp Ther 1990;252:531-8.
67. Hwang MW, Matsumori A, Furukawa Y, et al. Neutralization of interleukin-1beta in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling. J Am Coll Cardiol 2001;38:1546-53.
68. Maekawa N, Wada H, Kanda T, et al. Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-alpha. J Am Coll Cardiol 2002;39:1229-35.
69. Kloner RA, Fishbein MC, Lew H, Maroko PR, Braunwald E. Mummification of the infarcted myocardium by high dose corticosteroids. Circulation 1978;57:56-63.
70. Entman ML, Youker KA, Frangogiannis N, et al. Is inflammation good for the ischemic heart: perspectives beyond the ordinary. Z Kardiol 2000;89 (Suppl 9):IX/82-7.
71. Roberts R, DeMello V, Sobel BE. Deleterious effects of methylprednisolone in patients with myocardial infarction. Circulation 1976;53:1204-6.
72. Li C, Browder W, Kao RL. Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. Am J Physiol 1999;276:H543-52.
73. Li C, Kao RL, Ha T, Kelley J, Browder IW, Williams DL. Early activation of IKKbeta during in vivo myocardial ischemia. Am J Physiol Heart Circ Physiol 2001;280:H1264-71.
74. Mustapha S, Kirshner A, de Moissac D, Kirshenbaum LA. A direct requirement of nuclear factor-kappa B for suppression of apoptosis in ventricular myocytes. Am J Physiol 2000;279:H939-45.
75. Morishita R, Sugimoto T, Aoki M, et al. In vivo transfection of cis element "decoy" against nuclear factor- kappaB binding site prevents myocardial infarction. Nat Med 1997;3:894-9.
76. Kupatt C, Wichels R, Deiss M, et al. Retroinfusion of NFkappaB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs. Gene Ther 2002;9:518-26.
77. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003;9:575-81.
78. Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I (kappa)B kinase-beta. Nature 1998;396:77-80.
79. Burke JR, Pattoli MA, Gregor KR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 2003;278:1450-6.
80. Misra A, Haudek SB, Knuefermann P, et al. Nuclear factor-κB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. Circulation 2003;108:3075-8.
81. Squadrito F, Deodato B, Squadrito G, et al. Gene transfer of IkappaBalpha limits infarct size in a mouse model of myocardial ischemia-reperfusion injury. Lab Invest 2003;83:1097-104.
82. Qi WN, Chaiyakit P, Cai Y, et al. NF-kappaB p65 involves in reperfusion injury and iNOS gene regulation in skeletal muscle. Microsurgery 2004;24:316-23.
83. Onai Y, Suzuki J, Kakuta T, et al. Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc Res 2004;63:51-9.
84. Trescher K, Bernecker O, Fellner B, et al. Adenovirus-mediated overexpression of inhibitor kappa B-alpha attenuates postinfarct remodeling in the rat heart. Eur J Cardiothorac Surg 2004;26: 960-7.
85. Regula KM, Baetz D, Kirshenbaum LA. Nuclear factor-κB represses hypoxia-induced mitochondrial defects and cell death of ventricular myocytes. Circulation 2004;110:3795-802.
86. Hua F, Ha T, Ma J, et al. Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts. Biochem Biophys Res Comm 2005;338:1118-25.