MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

Nature

Volumn 398, Issue 6729, 1999, Pages 718-725

  Gerszten, Robert E ^a,b   Garcia Zepeda, Eduardo A ^a,b   Lim, Yaw Chyn ^b,c   Yoshida, Masayuki ^d   Ding, Han A ^c   Gimbrone Jr , Michael A ^b,c   Luster, Andrew D ^a,b   Luscinskas, Francis W ^b,c   Rosenzwelg, Anthony ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BLOOD FLOW; CELL ADHESION; CELL CULTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MONOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

CELL ADHESION; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; E-SELECTIN; ENDOTHELIUM, VASCULAR; GENE TRANSFER TECHNIQUES; HUMANS; INTERLEUKIN-8; MONOCYTES; RECEPTORS, LEUKOCYTE-ADHESION; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0033594416     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/19546     Document Type: Article

References (29)

1. Smith, J. D. et al. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc. Natl Acad. Sci. USA 92, 8264-8268 (1995).
2. Suzuki, H. et al. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386, 292-296 (1997).
3. Fazio, S. et al. Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proc. Natl Acad. Sci. USA 94, 4647-4652 (1997).
4. Nelken, N. A., Coughlin, S. R., Gordon, D. & Wilcox, J. N. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88, 1121-1127 (1991).
5. Koch, A. E. et al. Enhanced production of the chemotactic cytokines interleukin-8 and monocyte chemoattractant protein-1 in human abdominal aortic aneurysms. Am. J. Pathol. 142, 1423-1431 (1993).
6. Boisvert, W. A., Santiago, R., Curtiss, L. K. & Terkeltaub, R. A. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J. Clin. Invest. 101, 353-363 (1998).
7. Boring, L., Goslin, J., Cleary, M. & Charo, I. Decreased lesion formation in CCR2-/-mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394, 894-897 (1998).
8. Baggiolini, M., Dewald, B. & Moser, B. Interleukin-8 and related chemokines - CXC and CC chemokines. Adv. Immunol. 55, 97-179 (1994).
9. Gerszten, R. E. et al. Adhesion of monocytes to vascular cell adhesion molecule-I-transduced human endothelial cells: implications for atherogenesis. Circ. Res. 82, 871-878 (1998).
10. Berkhout, T. A. et al. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemoattractant protein (MCP) family that binds and signals through the CC chemokine receptor 2B. J. Biol. Chem. 272, 16404-16413 (1997).
11. Springer, T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314 (1994).
12. Weber, C., Alon, R., Moser, B. & Springer, T. A. Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis. J. Cell Biol. 134, 1063-1073 (1996).
13. Woldemar-Carr, M., Alon, R. & Springer, T. A. The C-C chemokine MCP-1 differentially modulates the avidity of β1 and β2 integrins on T lymphocytes. Immunity 4, 179-187 (1996).
14. Yoshimura, T. et al. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc. Natl Acad. Sci. USA 84, 9233-9237 (1987).
15. Schroder, J. M., Mrowietz, U., Morita, E. & Christophers, E. Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin I activity. J. Immunol. 139, 3474-3483 (1987).
16. Chuntharapai, A., Lee, J., Hebert, C. A. & Kim, K. J. Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes. J. Immunol. 153, 5682-5688 (1994).
17. Premack, B. A. & Schall, T. J. Chemokine receptors: gateways to inflammation and infection. Nat. Med. 2, 1174-1178 (1996).
18. Jones, K. A. et al. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 396, 674-679 (1998).
19. Luscinskas, F. W. et al. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J. Cell Biol. 125, 1417-1427 (1994).
20. Gerszten, R. et al. Adhesion of memory lymphocytes to VCAM-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro. Circ. Res. 79, 1205-1215 (1996).
21. Yoshida, M., Szente, B. E., Kiely, J.-M., Rosenzweig, A. & Gimbrone, M. A. Regulation of E-selectin phosphorylation during leukocyte adhesion: a novel outside-in signaling role for E-selectin. J. Immunol. 161, 933-941 (1997).
22. Graber, N. et al. T cells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1. J. Immunol 145, 819-850 (1990).
23. Bevilacqua, M. P., Prober, J. S., Mendrick, D. L., Cotran, R. S. & Gimbrone, M. A. Identification of an inducible endothelial-leukocyte adhesion molecule. Proc. Natl Acad. Sci. USA 84, 9238-9242 (1987).
24. Luscinskas, F. W. et al. Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1. J. Immunol. 146, 1617-1625 (1991).
25. Taichman, D. B. et al. Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1. Cell Regul. 2, 347-355 (1991).
26. Luscinskas, F. W. et al. L-and P-setectins, but not CD49d (VLA4) integrins, mediate monocyte initial attachment to TNF-activated vascular endothelium in vitro. J. Immunol. 156, 326-335 (1996).
27. Shen, J., Luscinskas, F. W., Conolly, A., Dewey, C. F. J. & Gimbrone, M. A. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am. J. Physiol. 262, C384-390 (1992).
28. Wheeler, M. E., Luscinskas, F. W., Bevilacqua, M. P. & Gimbrone, M. A. Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion. J. Clin. Invest. 82, 1211-1218 (1988).
29. Falk, W., Goodwin, R. H. Jr & Leonard, E. J. A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Meth. 33, 239-247 (1980).