Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate

Biological Chemistry

Volumn 385, Issue 5, 2004, Pages 435-438

  Gelhaus, Christoph ^a,c   Vicik, Radim ^a   Hilgenfeld, Rolf ^b   Schmidt, Christian L ^b   Leippe, Matthias ^a,c   Schirmeister, Tanja ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Affinity label; Aziridine; Cathepsin L; Falcipain 2; Malaria; Plasmodium

Indexed keywords

ANTIMALARIAL AGENT; AZIRIDINE DERIVATIVE; AZIRIDINE DICARBOXYLIC ACID; BIOTIN; CATHEPSIN L; CYSTEINE PROTEINASE; ESTER DERIVATIVE; HEMOGLOBIN; PROTEINASE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; CELL DEATH; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; ERYTHROCYTE; HOST CELL; HUMAN; HUMAN CELL; INCUBATION TIME; LIFE CYCLE; MALARIA; MITOSIS INHIBITION; MORPHOLOGY; NONHUMAN; PARASITE DEVELOPMENT; PARASITE SURVIVAL; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTIMALARIALS; AZIRIDINES; BIOTINYLATION; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PLASMODIUM;

PLASMODIUM FALCIPARUM;

EID: 2942709796     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2004.050     Document Type: Article

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