Peptidyl allyl sulfones: A new class of inhibitors for clan CA cysteine proteases

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 19, 2004, Pages 5203-5211

  Götz, Marion G ^a   Caffrey, Conor R ^b   Hansell, Elizabeth ^b   McKerrow, James H ^b   Powers, James C ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cathepsins; Cruzain; Cysteine protease inhibitor; Vinyl sulfone

Indexed keywords

2 (1 BENZYLOXYCARBONYLLEUCYLAMINOETHYL)OXAZOLINE; CALPAIN; CATHEPSIN B; CATHEPSIN L; CRUZIPAIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; EPOXIDE; PAPAIN; PHENYL 3 (N CARBOBENZYLOXYALANYL)AMINO 4 PHENYLBUT 2 ENYLSULFONE; PHENYL 3 (N CARBOBENZYLOXYLEUCYL)AMINO 4 PHENYLBUT 1 ENYLSULFONE; PHENYL 3 (N CARBOBENZYLOXYLEUCYL)AMINO 4 PHENYLBUT 2 ENYLSULFONE; PHENYL 3 (N CARBOBENZYLOXYVALYL)AMINO 4 PHENYLBUT 2 ENYLSULFONE; RHODESAIN; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; OXIDATION; STEREOCHEMISTRY;

ANIMALS; CATTLE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; ERYTHROCYTES; INHIBITORY CONCENTRATION 50; KINETICS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 4444338857     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.016     Document Type: Article

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