Pneumococcal meningitis in adults: New approaches to management and prevention

Lancet Neurology

Volumn 5, Issue 4, 2006, Pages 332-342

  Weisfelt, Martijn ^a   De Gans, Jan ^a   Van Der Poll, Tom ^a   Van De Beek, Diederik ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIOXIDANT; BB 1101; CEFEPIME; CEFOTAXIME; CEFTRIAXONE; CHLORAMPHENICOL; DAPTOMYCIN; DEXAMETHASONE; ERTAPENEM; GARENOXACIN; GATIFLOXACIN; GEMIFLOXACIN; ILOMASTAT; MEROPENEM; MOXIFLOXACIN; PENICILLIN G; PNEUMOCOCCUS POLYSACCHARIDE; PNEUMOCOCCUS VACCINE; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; BACTERIAL MENINGITIS; CEREBROSPINAL FLUID ANALYSIS; CLINICAL EXAMINATION; CLINICAL FEATURE; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; DRUG EFFICACY; ERADICATION THERAPY; GRAM STAINING; HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; MORBIDITY; MORTALITY; NEUROLOGICAL COMPLICATION; PRIORITY JOURNAL; RADIODIAGNOSIS; REVIEW; SYSTEMIC DISEASE; TREATMENT OUTCOME; VACCINATION;

ANTI-INFECTIVE AGENTS; HUMANS; INCIDENCE; MENINGITIS, BACTERIAL; MENINGITIS, PNEUMOCOCCAL; META-ANALYSIS; MODELS, BIOLOGICAL; PROGNOSIS; VACCINES, CONJUGATE;

EID: 33644989941     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(06)70409-4     Document Type: Review

References (93)

1. A Schuchat, K Robinson, JD Wenger Bacterial meningitis in the United States in 1995 N Engl J Med 337 1997 970 976
2. AR Tunkel Bacterial meningitis 2001 Lippincott Williams & Wilkins Philadelphia
3. MN Swartz Bacterial meningitis: a view of the past 90 years N Engl J Med 351 2004 1826 1828
4. H Peltola Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates Clin Microbiol Rev 13 2000 302 317
5. WR Short, AR Tunkel Changing epidemiology of bacterial meningitis in the United States Curr Infect Dis Rep 2 2000 327 331
6. M Weisfelt, D van de Beek, L Spanjaard, JB Reitsma, J de Gans Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series Lancet Neurol 5 2006 123 129
7. S Kastenbauer, HW Pfister Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases Brain 126 2003 1015 1025
8. C Ostergaard, HB Konradsen, S Samuelsson Clinical presentation and prognostic factors of Streptococcus pneumoniae meningitis according to the focus of infection BMC Infect Dis 5 2005 93
9. M Auburtin, R Porcher, F Bruneel Pneumococcal meningitis in the intensive care unit: prognostic factors of clinical outcome in a series of 80 cases Am J Respir Crit Care Med 165 2002 713 717
10. GA Bruyn, HP Kremer, S de Marie, GW Padberg, J Hermans, R van Furth Clinical evaluation of pneumococcal meningitis in adults over a twelve-year period Eur J Clin Microbiol Infect Dis 8 1989 695 700
11. B Hoen, JF Viel, A Gerard, JB Dureux, P Canton Mortality in pneumococcal meningitis: a multivariate analysis of prognostic factors Eur J Med 2 1993 28 32
12. RJ Stanek, MA Mufson A 20-year epidemiological study of pneumococcal meningitis Clin Infect Dis 28 1999 1265 1272
13. P Kragsbjerg, J Kallman, P Olcen Pneumococcal meningitis in adults Scand J Infect Dis 26 1994 659 666
14. B Sigurdardottir, OM Bjornsson, KE Jonsdottir, H Erlendsdottir, S Gudmundsson Acute bacterial meningitis in adults: a 20-year overview Arch Intern Med 157 1997 425 430
15. ML Durand, SB Calderwood, DJ Weber Acute bacterial meningitis in adults: a review of 493 episodes N Engl J Med 328 1993 21 28
16. D van de Beek, J de Gans, L Spanjaard, M Weisfelt, JB Reitsma, M Vermeulen Clinical features and prognostic factors in adults with bacterial meningitis N Engl J Med 351 2004 1849 1859
17. J Attia, R Hatala, DJ Cook, JG Wong The rational clinical examination: does this adult patient have acute meningitis? JAMA 282 1999 175 181
18. H van Crevel, A Hijdra, J de Gans Lumbar puncture and the risk of herniation: when should we first perform CT? J Neurol 249 2002 129 137
19. D van de Beek, J de Gans, AR Tunkel, EFM Wijdicks Community-acquired bacterial meningitis in adults N Engl Med 354 2006 44 53
20. A Spanos, FE Harrell Jr, DT Durack Differential diagnosis of acute meningitis: an analysis of the predictive value of initial observations JAMA 262 1989 2700 2707
21. P Radstrom, A Backman, N Qian, P Kragsbjerg, C Pahlson, P Olcen Detection of bacterial DNA in cerebrospinal fluid by an assay for simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and streptococci using a seminested PCR strategy J Clin Microbiol 32 1994 2738 2744
22. W Weststrate, A Hijdra, J de Gans Brain infarcts in adults with bacterial meningitis Lancet 347 1996 399
23. HW Pfister, W Feiden, KM Einhaupl Spectrum of complications during bacterial meningitis in adults: results of a prospective clinical study Arch Neurol 50 1993 575 581
24. SI Aronin, P Peduzzi, VJ Quagliarello Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing Ann Intern Med 129 1998 862 869
25. N Proulx, D Frechette, B Toye, J Chan, S Kravcik Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis QJM 98 2005 291 298
26. D van de Beek, J de Gans, P McIntyre, K Prasad Corticosteroids in acute bacterial meningitis Cochrane Database Syst Rev 3 2003 CD004305
27. D van de Beek, J de Gans, P McIntyre, K Prasad Steroids in adults with acute bacterial meningitis: a systematic review Lancet Infect Dis 4 2004 139 143
28. J de Gans, D van de Beek Dexamethasone in adults with bacterial meningitis N Engl J Med 347 2002 1549 1556
29. AR Tunkel, BJ Hartman, SL Kaplan Practice guidelines for the management of bacterial meningitis Clin Infect Dis 39 2004 1267 1284
30. L Cronin, DJ Cook, J Carlet Corticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature Crit Care Med 23 1995 1430 1439
31. MM Paris, SM Hickey, MI Uscher, S Shelton, KD Olsen, GH McCracken Jr Effect of dexamethasone on therapy of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis Antimicrob Agents Chemother 38 1994 1320 1324
32. SL Leib, C Heimgartner, YD Bifrare, JM Loeffler, MG Taauber Dexamethasone aggravates hippocampal apoptosis and learning deficiency in pneumococcal meningitis in infant rats Pediatr Res 54 2003 353 357
33. J Irazuzta, RK Pretzlaff, G Courten-Myers, F Zemlan, B Zingarelli Dexamethasone decreases neurological sequelae and caspase activity Intensive Care Med 31 2005 146 150
34. D van de Beek, B Schmand, J de Gans Cognitive impairment in adults with good recovery after bacterial meningitis J Infect Dis 186 2002 1047 1052
35. DA McMillan, CY Lin, SI Aronin, VJ Quagliarello Community-acquired bacterial meningitis in adults: categorization of causes and timing of death Clin Infect Dis 33 2001 969 975
36. U Koedel, WM Scheld, HW Pfister Pathogenesis and pathophysiology of pneumococcal meningitis Lancet Infect Dis 2 2002 721 736
37. R Nau, W Bruck Neuronal injury in bacterial meningitis: mechanisms and implications for therapy Trends Neurosci 25 2002 38 45
38. D Bogaert, R de Groot, PW Hermans Streptococcus pneumoniae colonisation: the key to pneumococcal disease Lancet Infect Dis 4 2004 144 154
39. JP Nuorti, JC Butler, MM Farley Cigarette smoking and invasive pneumococcal disease N Engl J Med 342 2000 681 689
40. DR Cundell, NP Gerard, C Gerard, I Idanpaan-Heikkila, EI Tuomanen Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor Nature 377 1995 435 438
41. EI Tuomanen The biology of pneumococcal infection Pediatr Res 42 1997 253 258
42. KS Kim Pathogenesis of bacterial meningitis: from bacteraemia to neuronal injury Nat Rev Neurosci 4 2003 376 385
43. K Overweg, CD Pericone, GG Verhoef Differential protein expression in phenotypic variants of Streptococcus pneumoniae Infect Immun 68 2000 4604 4610
44. CJ Orihuela, G Gao, KP Francis, J Yu, EI Tuomanen Tissue-specific contributions of pneumococcal virulence factors to pathogenesis J Infect Dis 190 2004 1661 1669
45. IR Friedland, MM Paris, S Hickey The limited role of pneumolysin in the pathogenesis of pneumococcal meningitis J Infect Dis 172 1995 805 809
46. WM Scheld, U Koedel, B Nathan, HW Pfister Pathophysiology of bacterial meningitis: mechanisms of neuronal injury J Infect Dis 186 2002 S225 S233
47. S Akira Toll-like receptors and innate immunity Adv Immunol 78 2001 1 56
48. U Koedel, T Rupprecht, B Angele MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS Brain 127 2004 1437 1445
49. EI Tuomanen, K Saukkonen, S Sande, C Cioffe, SD Wright Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes J Exp Med 170 1989 959 969
50. SL Leib, JM Clements, RL Lindberg Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis Brain 124 2001 1734 1742
51. BC Kieseier, R Paul, U Koedel Differential expression of matrix metalloproteinases in bacterial meningitis Brain 122 1999 1579 1587
52. SL Leib, D Leppert, J Clements, MG Tauber Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis Infect Immun 68 2000 615 620
53. V Pomar, S Martinez, R Paredes, P Domingo Advances in adjuvant therapy against acute bacterial meningitis Curr Drug Targets Infect Disord 4 2004 303 309
54. H Tsukahara, T Haruta, Y Todoroki Oxidant and antioxidant activities in childhood meningitis Life Sci 71 2002 2797 2806
55. U Koedel, HW Pfister Protective effect of the antioxidant N-acetyl-L-cysteine in pneumococcal meningitis in the rat Neurosci Lett 225 1997 33 36
56. M Auer, LA Pfister, D Leppert, MG Tauber, SL Leib Effects of clinically used antioxidants in experimental pneumococcal meningitis J Infect Dis 182 2000 347 350
57. SL Leib, YS Kim, LL Chow, RA Sheldon, MG Tauber Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci J Clin Invest 98 1996 2632 2639
58. JM Loeffler, R Ringer, M Hablutzel, MG Tauber, SL Leib The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis J Infect Dis 183 2001 247 252
59. F Winkler, U Koedel, S Kastenbauer, HW Pfister Differential expression of nitric oxide synthases in bacterial meningitis: role of the inducible isoform for blood-brain barrier breakdown J Infect Dis 183 2001 1749 1759
60. U Koedel, R Paul, F Winkler, S Kastenbauer, PL Huang, HW Pfister Lack of endothelial nitric oxide synthase aggravates murine pneumococcal meningitis J Neuropathol Exp Neurol 60 2001 1041 1050
61. U Koedel, F Winkler, B Angele, A Fontana, HW Pfister Meningitis- associated central nervous system complications are mediated by the activation of polyADP-ribose polymerase J Cereb Blood Flow Metab 22 2002 39 49
62. M Klein, U Koedel, HW Pfister, S Kastenbauer Meningitis-associated hearing loss: protection by adjunctive antioxidant therapy Ann Neurol 54 2003 451 458
63. U Koedel, F Winkler, B Angele, A Fontana, RA Flavell, HW Pfister Role of Caspase-1 in experimental pneumococcal meningitis: evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice Ann Neurol 51 2002 319 329
64. JS Braun, R Novak, KH Herzog, SM Bodner, JL Cleveland, EI Tuomanen Neuroprotection by a caspase inhibitor in acute bacterial meningitis Nat Med 5 1999 298 302
65. C Gianinazzi, D Grandgirard, H Imboden Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis Acta Neuropathol Berl 105 2003 499 507
66. K Saukkonen, S Sande, C Cioffe The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis J Exp Med 171 1990 439 448
67. C Ostergaard, RV Yieng-Kow, T Benfield, N Frimodt-Moller, F Espersen, JD Lundgren Inhibition of leukocyte entry into the brain by the selectin blocker fucoidin decreases interleukin-1 IL-1 levels but increases IL-8 levels in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits Infect Immun 68 2000 3153 3157
68. I Bogdan, SL Leib, M Bergeron, L Chow, MG Tauber Tumor necrosis factor-alpha contributes to apoptosis in hippocampal neurons during experimental group B streptococcal meningitis J Infect Dis 176 1997 693 697
69. TQ Tan, CW Smith, EP Hawkins, EO Mason Jr, SL Kaplan Hematogenous bacterial meningitis in an intercellular adhesion molecule-1-deficient infant mouse model J Infect Dis 171 1995 342 349
70. LA Pfister, JH Tureen, S Shaw Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis Ann Neurol 47 2000 329 335
71. U Koedel, I Bayerlein, R Paul, B Sporer, HW Pfister Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental pneumococcal meningitis J Infect Dis 182 2000 1437 1445
72. S Kastenbauer, U Koedel, F Weih, L Ziegler-Heitbrock, HW Pfister Protective role of NF-kappaB1 p50 in experimental pneumococcal meningitis Eur J Pharmacol 498 2004 315 318
73. AK Stringaris, J Geisenhainer, F Bergmann Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase Neurobiol Dis 11 2002 355 368
74. YD Bifrare, J Kummer, P Joss, MG Tauber, SL Leib Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis J Infect Dis 191 2005 40 45
75. CT Brandt, JD Lundgren, N Frimodt-Moller Blocking of leukocyte accumulation in the cerebrospinal fluid augments bacteremia and increases lethality in experimental pneumococcal meningitis J Neuroimmunol 166 2005 126 131
76. JC Butler, SF Dowell, RF Breiman Epidemiology of emerging pneumococcal drug resistance: implications for treatment and prevention Vaccine 16 1998 1693 1697
77. CG Whitney, MM Farley, J Hadler Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States N Engl J Med 343 2000 1917 1924
78. DH Mattie, K Stuertz, R Nau, JT van Dissel Pharmacodynamics of antibiotics with respect to bacterial killing of and release of lipoteichoic acid by Streptococcus pneumoniae J Antimicrob Chemother 56 2005 154 159
79. VE Garcia, J Mensa, JA Martinez Lower mortality among patients with community-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a beta-lactam agent alone Eur J Clin Microbiol Infect Dis 24 2005 190 195
80. L Flatz, M Cottagnoud, F Kuhn, J Entenza, A Stucki, P Cottagnoud Ceftriaxone acts synergistically with levofloxacin in experimental meningitis and reduces levofloxacin-induced resistance in penicillin-resistant pneumococci J Antimicrob Chemother 53 2004 305 310
81. WP Hausdorff, DR Feikin, KP Klugman Epidemiological differences among pneumococcal serotypes Lancet Infect Dis 5 2005 83 93
82. J Bernatoniene, A Finn Advances in pneumococcal vaccines: advantages for infants and children Drugs 65 2005 229 255
83. RR Reinert Pneumococcal conjugate vaccines: a European perspective Int J Med Microbiol 294 2004 277 294
84. CG Whitney, MM Farley, J Hadler Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine N Engl J Med 348 2003 1737 1746
85. S Conaty, L Watson, J Dinnes, N Waugh The effectiveness of pneumococcal polysaccharide vaccines in adults: a systematic review of observational studies and comparison with results from randomised controlled trials Vaccine 22 2004 3214 3224
86. E Swiatlo, D Ware Novel vaccine strategies with protein antigens of Streptococcus pneumoniae FEMS Immunol Med Microbiol 38 2003 1 7
87. JC Butler, ED Shapiro, GM Carlone Pneumococcal vaccines: history, current status, and future directions Am J Med 107 1999 69S 76S
88. D Goldblatt, M Hussain, N Andrews Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study J Infect Dis 192 2005 387 393
89. HY Wu, MH Nahm, Y Guo, MW Russell, DE Briles Intranasal immunization of mice with PspA pneumococcal surface protein A can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae J Infect Dis 175 1997 839 846
90. DE Briles, SK Hollingshead, JC Paton Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae J Infect Dis 188 2003 339 348
91. JC Paton, RA Lock, DJ Hansman Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae Infect Immun 40 1983 548 552
92. MT Coats, WH Benjamin, SK Hollingshead, DE Briles Antibodies to the pneumococcal surface protein A, PspA, can be produced in splenectomized mice and can protect splenectomized mice from infection with Streptococcus pneumoniae Vaccine 23 2005 4257 4262
93. A Knaust, M Frosch Genome-based vaccines Int J Med Microbiol 294 2004 295 301