Dexamethasone aggravates hippocampal apoptosis and learning deficiency in pneumococcal meningitis in infant rats

Pediatric Research

Volumn 54, Issue 3, 2003, Pages 353-357

  Leib, Stephen L ^a   Heimgartner, Chris ^a   Bifrare, Yoeng Delphine ^a   Loeffler, Jutta M ^a   Täuber, Martin G ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CEFTRIAXONE; DEXAMETHASONE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; APOPTOSIS; ARTICLE; BACTERIAL MENINGITIS; CONTROLLED STUDY; HIPPOCAMPUS; HISTOPATHOLOGY; LEARNING; LEARNING DISORDER; MAZE TEST; MENINGITIS; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; STEROID THERAPY;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; DEXAMETHASONE; GLUCOCORTICOIDS; HIPPOCAMPUS; MAZE LEARNING; MENINGITIS, PNEUMOCOCCAL; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0041467288     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000079185.67878.72     Document Type: Article

References (36)

1. Tuomanen E 1994 Modulation of inflammation in bacterial meningitis. Isr J Med Sci 30:339-341
2. Leib SL, Täuber MG 1999 Pathogenesis of bacterial meningitis. Infect Dis Clin North Am 13:527-548
3. Pfister HW, Koedel U, Paul R 1999 Acute Meningitis. Curr Infect Dis Rep 1:153-159
4. Goetghebuer T, West TE, Wermenbol V, Cadbury AL, Milligan P, Lloyd-Evans N, Adegbola RA, Mulholland EK, Greenwood BM, Weber MW 2000 Outcome of meningitis caused by Streptococcus pneumoniae and Haemophilus influenzae type b in children in The Gambia. Trop Med Int Health 5:207-213
5. Daoud AS, al-Sheyyab M, Batchoun RG, Rawashdeh MO, Nussair MM, Pugh RN 1995 Bacterial meningitis: still a cause of high mortality and severe neurological morbidity in childhood. J Trop Pediatr 41:308-310
6. Bedford H, de Louvois J, Halket S, Peckham C, Hurley R, Harvey D 2001 Meningitis in infancy in England and Wales: follow up at age 5 years. BMJ 323:533-536
7. Grimwood K, Anderson P, Anderson V, Tan L, Nolan T 2000 Twelve year outcomes following bacterial meningitis: further evidence for persisting effects. Arch Dis Child 83:111-116
8. Merkelbach S, Sittinger H, Schweizer I, Muller M 2000 Cognitive outcome after bacterial meningitis. Acta Neurol Scand 102:118-123
9. Almuneef M, Memish Z, Khan Y, Kagallwala A, Alshaalan M 1998 Childhood bacterial meningitis in Saudi Arabia, J Infect 36:157-160
10. Coyle PK 1999 Glucocorticoids in central nervous system bacterial infection. Arch Neurol 56:796-801
11. McIntyre PB, Berkey CS, King SM, Schaad UB, Kilpi T, Kanra GY, Perez CM 1997 Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988. JAMA 278:925-931
12. Daoud AS, Batieha A, Al-Sheyyab M, Abuekteish F, Obeidat A, Mahafza T 1999 Lack of effectiveness of dexamethasone in neonatal bacterial meningitis. Eur J Pediatr 158:230-233
13. Schuchat A, Robinson K, Wenger JD, Harrison LH, Farley M, Reingold AL, Lefkowitz L, Perkins BA 1997 Bacterial meningitis in the United States in 1995. Active Surveillance Team N Engl J Med 337:970-976
14. Thomas R, Le Tulzo Y, Bouget J, Camus C, Michelet C, Le Corre P, Bellissant E 1999 Trial of dexamethasone treatment for severe bacterial meningitis in adults. Adult Meningitis Steroid Group Intensive Care Med 25:475-480.
15. Williams AJ, Nadel S 2001 Bacterial meningitis: current controversies in approaches to treatment. CNS Drugs 15:909-919.
16. Nau R, Soto A, Bruck W 1999 Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J Neuropathol Exp Neurol 58:265-274
17. Leib SL, Clements JM, Lindberg RL, Heimgartner C, Loeffler JM, Pfister LA, Täuber MG, Leppert D 2001 Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain 124:1734-1742
18. Zysk G, Bruck W, Gerber J, Bruck Y, Prange HW, Nau R 1996 Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis. J Neuropathol Exp Neurol 55:722-728
19. Loeffler JM, Ringer R, Hablutzel M, Tauber MG, Leib SL 2001 The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. J Infect Dis 183:247-252
20. Leib SL, Kim YS, Ferriero DM, Täuber MG 1996 Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis. J Infect Dis 173:166-171
21. Scoville WB, Milner B 2000 Loss of recent memory after bilateral hippocampal lesions, 1957. J Neuropsychiatry Clin Neurosci 12:103-113
22. Morris RG, Garrud P, Rawlins JN, O'Keefe J 1982 Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683
23. Wellmer A, Noeske C, Gerber J, Munzel U, Nau R 2000 Spatial memory and learning deficits after experimental pneumococcal meningitis in mice. Neurosci Lett 296:137-140
24. Pfister LA, Tureen JH, Shaw S, Christen S, Ferriero DM, Tauber MG, Leib SL 2000 Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis. Ann Neurol 47:329-335.
25. Auer M, Pfister LA, Leppert D, Tauber MG, Leib SL 2000 Effects of clinically used antioxidants in experimental pneumococcal meningitis. J Infect Dis 182:347-350
26. Flagel SB, Vazquez DM, Watson SJ, Jr., Neal CR, Jr 2002 Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response. Am J Physiol Regul Integr Comp Physiol 282:R55-63
27. Kim YS, Sheldon RA, Elliott BR, Liu Q, Ferriero DM, Täuber MG 1995 Brain injury in experimental neonatal meningitis due to group B streptococci. J Neuropathol Exp Neurol 54:531-539
28. de Gans J, van de Beek D 2002 Dexamethasone in adults with bacterial meningitis. N Engl J Med 347:1549-1556
29. Tornello S, Orti E, De Nicola AF, Rainbow TC, McEwen BS 1982 Regulation of glucocorticoid receptors in brain by corticosterone treatment of adrenalectomized rats. Neuroendocrinology 35:411-417
30. Almeida OF, Conde GL, Crochemore C, Demeneix BA, Fischer D, Hassan AH, Meyer M, Holsboer F, Michaelidis TM 2000 Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J 14:779-790
31. Haynes LE, Griffiths MR, Hyde RE, Barber DJ, Mitchell IJ 2001 Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disorders. Neuroscience 104:57-69
32. Sousa N, Paula-Barbosa MM, Almeida OF 1999 Ligand and subfield specificity of corticoid-induced neuronal loss in the rat hippocampal formation. Neuroscience 89:1079-1087
33. Keenan PA, Jacobson MW, Soleymani RM, Mayes MD, Stress ME, Yaldoo DT 1996 The effect on memory of chronic prednisone treatment in patients with systemic disease. Neurology 47:1396-1402
34. Gianinazzi C, Grandgirard S, Imboden H, Egger L, Meli DN, Bifrare YD, Joss PC, Täuber MG, Borner C, Leib SL 2003 Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta Neuropathol (Berl) 105:499-507
35. Braun JS, Novak R, Herzog KH, Bodner SM, Cleveland JL, Tuomanen EI 1999 Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nat Med 5:298-302
36. Hassan AH, von Rosenstiel P, Patchev VK, Holsboer F, Almeida OF 1996 Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone. Exp Neurol 140:43-52