-
1
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
Glenner GG, Wong CW. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984; 120(3): 885-890.
-
(1984)
Biochem Biophys Res Commun
, vol.120
, Issue.3
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
2
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner GG, Wong CW. Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1984; 122(3): 1131-1135.
-
(1984)
Biochem Biophys Res Commun
, vol.122
, Issue.3
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
3
-
-
0006876721
-
Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease
-
van Duinen SG, Castaño EM, Prelli F, Bots GT, Luyendijk W, Frangione B. Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease. Proc Natl Acad Sci USA 1987; 84(16): 5991-5994.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, Issue.16
, pp. 5991-5994
-
-
Van Duinen, S.G.1
Castaño, E.M.2
Prelli, F.3
Bots, G.T.4
Luyendijk, W.5
Frangione, B.6
-
4
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
-
Levy E, Carman MD, Fernandez-Madrid IJ, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990; 248(4959): 1124-1126.
-
(1990)
Science
, vol.248
, Issue.4959
, pp. 1124-1126
-
-
Levy, E.1
Carman, M.D.2
Fernandez-Madrid, I.J.3
-
5
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349(6311): 704-706.
-
(1991)
Nature
, vol.349
, Issue.6311
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
-
6
-
-
0025950987
-
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
-
Murrell J, Farlow M, Ghetti B, Benson MD. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 1991; 254(5028): 97-99.
-
(1991)
Science
, vol.254
, Issue.5028
, pp. 97-99
-
-
Murrell, J.1
Farlow, M.2
Ghetti, B.3
Benson, M.D.4
-
7
-
-
0026075602
-
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
-
Chartier-Harlin MC, Crawford F, Houlden H, et al. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 1991; 353(6347): 844-846.
-
(1991)
Nature
, vol.353
, Issue.6347
, pp. 844-846
-
-
Chartier-Harlin, M.C.1
Crawford, F.2
Houlden, H.3
-
8
-
-
0026879650
-
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
-
Hendriks L, van Duijn CM, Cras P, et al. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet 1992; 1(3): 218-221.
-
(1992)
Nat Genet
, vol.1
, Issue.3
, pp. 218-221
-
-
Hendriks, L.1
Van Duijn, C.M.2
Cras, P.3
-
9
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
-
Mullan M, Crawford F, Axelman K, et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1992; 1(5): 345-347.
-
(1992)
Nat Genet
, vol.1
, Issue.5
, pp. 345-347
-
-
Mullan, M.1
Crawford, F.2
Axelman, K.3
-
10
-
-
0026745610
-
Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
-
Citron M, Oltersdorf T, Haass C, et al. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 1992; 360(6405): 672-674.
-
(1992)
Nature
, vol.360
, Issue.6405
, pp. 672-674
-
-
Citron, M.1
Oltersdorf, T.2
Haass, C.3
-
11
-
-
0028322017
-
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
-
Suzuki N, Cheung TT, Cai XD, et al. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 1994; 264(5163): 1336-1340.
-
(1994)
Science
, vol.264
, Issue.5163
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
-
12
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349(6311): 704-706.
-
(1991)
Nature
, vol.349
, Issue.6311
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
-
13
-
-
0034329742
-
Apoptosis in neurodegenerative disorders
-
Mattson MP. Apoptosis in neurodegenerative disorders. Nature Rev Mol Cell Biol 2000; 1: 120-129.
-
(2000)
Nature Rev Mol Cell Biol
, vol.1
, pp. 120-129
-
-
Mattson, M.P.1
-
14
-
-
0036054030
-
Dysregulation of neuronal differentiation and cell cycle control in Alzheimer's disease
-
Arendt T. Dysregulation of neuronal differentiation and cell cycle control in Alzheimer's disease. J Neural Transm Suppl 2002; (62): 77-85.
-
(2002)
J Neural Transm Suppl
, Issue.62
, pp. 77-85
-
-
Arendt, T.1
-
15
-
-
0034131044
-
Impaired proteasome function in Alzheimer's disease
-
Keller JN, Keith BH, Markesbery WR. Impaired proteasome function in Alzheimer's disease. J Neurochem 2000; 75(1): 436-439.
-
(2000)
J Neurochem
, vol.75
, Issue.1
, pp. 436-439
-
-
Keller, J.N.1
Keith, B.H.2
Markesbery, W.R.3
-
16
-
-
0033972037
-
Possible involvement of proteasome inhibition in aging: Implications for oxidative stress
-
Keller JN, Hanni KB, Markesbery WR. Possible involvement of proteasome inhibition in aging: Implications for oxidative stress. Mechanisms of Aging and Dev 2000; 113: 61-70.
-
(2000)
Mechanisms of Aging and Dev
, vol.113
, pp. 61-70
-
-
Keller, J.N.1
Hanni, K.B.2
Markesbery, W.R.3
-
17
-
-
6844258835
-
Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients
-
van Leeuwen FW, de Kleijn DP, van den Hurk HH, et al. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 1998; 279(5348): 242-247.
-
(1998)
Science
, vol.279
, Issue.5348
, pp. 242-247
-
-
Van Leeuwen, F.W.1
De Kleijn, D.P.2
Van Den Hurk, H.H.3
-
18
-
-
0034730172
-
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease
-
Lam YA, Pickart CM, Alban A, et al. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc Natl Acad Sci USA 2000; 97(18): 9902-9906.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.18
, pp. 9902-9906
-
-
Lam, Y.A.1
Pickart, C.M.2
Alban, A.3
-
19
-
-
15844408798
-
APP-BP1, a novel protein that binds to the carboxyl-termmal region of the amyloid precursor protein
-
Chow N, Korenberg JR, Chen XN, Neve RL. APP-BP1, a novel protein that binds to the carboxyl-termmal region of the amyloid precursor protein. J Biol Chem 1996; 271(19): 11339-11346.
-
(1996)
J Biol Chem
, vol.271
, Issue.19
, pp. 11339-11346
-
-
Chow, N.1
Korenberg, J.R.2
Chen, X.N.3
Neve, R.L.4
-
20
-
-
0034708641
-
The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons
-
Chen Y, McPhie DL, Hirschberg J, Neve RL. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J Biol Chem 2000; 275(12): 8929-8935.
-
(2000)
J Biol Chem
, vol.275
, Issue.12
, pp. 8929-8935
-
-
Chen, Y.1
McPhie, D.L.2
Hirschberg, J.3
Neve, R.L.4
-
21
-
-
0032146145
-
A new NEDD8-ligating system for cullin-4A
-
Osaka F, Kawasaki H, Aida N, et al. A new NEDD8-ligating system for cullin-4A. Genes Dev 1998; 12(15): 2263-2268.
-
(1998)
Genes Dev
, vol.12
, Issue.15
, pp. 2263-2268
-
-
Osaka, F.1
Kawasaki, H.2
Aida, N.3
-
22
-
-
0033597126
-
Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway
-
Gong L, Yeh ET. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem 1999; 274(17): 12036-12042.
-
(1999)
J Biol Chem
, vol.274
, Issue.17
, pp. 12036-12042
-
-
Gong, L.1
Yeh, E.T.2
-
23
-
-
0033581899
-
Covalent modification of all members of human cullin family proteins by NEDD8
-
Hori T, Osaka F, Chiba T, et al. Covalent modification of all members of human cullin family proteins by NEDD8. Oncogene 1999; 18(48): 6829-6834.
-
(1999)
Oncogene
, vol.18
, Issue.48
, pp. 6829-6834
-
-
Hori, T.1
Osaka, F.2
Chiba, T.3
-
24
-
-
0023623050
-
Isolation of temperature-sensitive mutants
-
Hirschberg J, Marcus M. Isolation of temperature-sensitive mutants. Methods Enzymol 1987; 151: 145-150.
-
(1987)
Methods Enzymol
, vol.151
, pp. 145-150
-
-
Hirschberg, J.1
Marcus, M.2
-
25
-
-
0026460979
-
The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1
-
Handeli S, Weintraub H. The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1. Cell 1992; 71(4): 599-611.
-
(1992)
Cell
, vol.71
, Issue.4
, pp. 599-611
-
-
Handeli, S.1
Weintraub, H.2
-
26
-
-
0035969236
-
The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice
-
Tateishi K, Omata M, Tanaka K, Chiba T. The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J Cell Biol 2001; 155(4): 571-579.
-
(2001)
J Cell Biol
, vol.155
, Issue.4
, pp. 571-579
-
-
Tateishi, K.1
Omata, M.2
Tanaka, K.3
Chiba, T.4
-
27
-
-
0142059983
-
APP-BP1 mediates APP-mduced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
-
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL. APP-BP1 mediates APP-mduced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. J Cell Biol 2003; 163(1): 27-33.
-
(2003)
J Cell Biol
, vol.163
, Issue.1
, pp. 27-33
-
-
Chen, Y.1
Liu, W.2
McPhie, D.L.3
Hassinger, L.4
Neve, R.L.5
-
28
-
-
0038673445
-
ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis
-
Chen Y, Liu W, Naumovski L, Neve RL. ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. J Neurochem 2003; 85(3): 801-809.
-
(2003)
J Neurochem
, vol.85
, Issue.3
, pp. 801-809
-
-
Chen, Y.1
Liu, W.2
Naumovski, L.3
Neve, R.L.4
-
29
-
-
0033279836
-
SCF and Cullin/Ring H2-based ubiquitin ligases
-
Deshaies RJ. SCF and Cullin/Ring H2-based ubiquitin ligases. Annu Rev Cell Dev Biol 1999; 15: 435-467.
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 435-467
-
-
Deshaies, R.J.1
-
30
-
-
0033666562
-
F-box proteins and protein degradation: An emerging theme in cellular regulation
-
del Pozo JC, Estelle M. F-box proteins and protein degradation: An emerging theme in cellular regulation. Plant Mol Biol 2000; 44(2): 123-128.
-
(2000)
Plant Mol Biol
, vol.44
, Issue.2
, pp. 123-128
-
-
Del Pozo, J.C.1
Estelle, M.2
-
31
-
-
0029953780
-
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family
-
Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 1996; 85(6): 829-839.
-
(1996)
Cell
, vol.85
, Issue.6
, pp. 829-839
-
-
Kipreos, E.T.1
Lander, L.E.2
Wing, J.P.3
He, W.W.4
Hedgecock, E.M.5
-
32
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin WG Jr. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2002; 2(9): 673-682.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.9
, pp. 673-682
-
-
Kaelin Jr., W.G.1
-
33
-
-
0037513423
-
Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans
-
Pintard L, Kurz T, Glaser S, Willis JH, Peter M, Bowerman B. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Curr Biol 2003; 13(11): 911-921.
-
(2003)
Curr Biol
, vol.13
, Issue.11
, pp. 911-921
-
-
Pintard, L.1
Kurz, T.2
Glaser, S.3
Willis, J.H.4
Peter, M.5
Bowerman, B.6
-
34
-
-
0037967230
-
CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing
-
Zhong W, Feng H, Santiago FE, Kipreos ET. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Nature 2003; 423(6942): 885-889.
-
(2003)
Nature
, vol.423
, Issue.6942
, pp. 885-889
-
-
Zhong, W.1
Feng, H.2
Santiago, F.E.3
Kipreos, E.T.4
-
35
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987; 325(6106): 733-736.
-
(1987)
Nature
, vol.325
, Issue.6106
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
-
36
-
-
0141462295
-
The amyloid precursor protein of Alzheimer's disease is found on the surface of static but not activity motile portions of neurites
-
Storey E, Spurck T, Pickett-Heaps J, Beyreuther K, Masters CL. The amyloid precursor protein of Alzheimer's disease is found on the surface of static but not activity motile portions of neurites. Brain Res 1996; 735(1): 59-66.
-
(1996)
Brain Res
, vol.735
, Issue.1
, pp. 59-66
-
-
Storey, E.1
Spurck, T.2
Pickett-Heaps, J.3
Beyreuther, K.4
Masters, C.L.5
-
37
-
-
0029967005
-
Alzheimer's beta-amyloid precursor protein is expressed on the surface of immediately ex vivo brain cells: A flow cytometric study
-
Jung SS, Nalbantoglu J, Cashman NR. Alzheimer's beta-amyloid precursor protein is expressed on the surface of immediately ex vivo brain cells: A flow cytometric study. J Neurosci Res 1996; 46(3): 336-348.
-
(1996)
J Neurosci Res
, vol.46
, Issue.3
, pp. 336-348
-
-
Jung, S.S.1
Nalbantoglu, J.2
Cashman, N.R.3
-
38
-
-
0029257190
-
Cell-surface β-amyloid precursor protein stimulates neunte outgrowth of hippocampal neurons in an isoform-dependent manner
-
Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface β-amyloid precursor protein stimulates neunte outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci 1995; 15: 2157-2167.
-
(1995)
J Neurosci
, vol.15
, pp. 2157-2167
-
-
Qiu, W.Q.1
Ferreira, A.2
Miller, C.3
Koo, E.H.4
Selkoe, D.J.5
-
39
-
-
0031031006
-
Trafficking of cell-surface beta-amyloid precursor protein: Evidence that a sorting intermediate participates in synaptic vesicle recycling
-
Marquez-Sterling NR, Lo AC, Sisodia SS, Koo EH. Trafficking of cell-surface beta-amyloid precursor protein: Evidence that a sorting intermediate participates in synaptic vesicle recycling. J Neurosci 1997; 17(1): 140-151.
-
(1997)
J Neurosci
, vol.17
, Issue.1
, pp. 140-151
-
-
Marquez-Sterling, N.R.1
Lo, A.C.2
Sisodia, S.S.3
Koo, E.H.4
-
40
-
-
0029950149
-
Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody
-
Koo EH, Squazzo SL, Selkoe DJ, Koo CH. Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J Cell Sci 1996; 109(Pt 5): 991-998.
-
(1996)
J Cell Sci
, vol.109
, Issue.5 PART
, pp. 991-998
-
-
Koo, E.H.1
Squazzo, S.L.2
Selkoe, D.J.3
Koo, C.H.4
-
41
-
-
0029934134
-
Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization
-
Yamazaki T, Koo EH, Selkoe DJ. Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. J Cell Sci 1996; 109(Pt 5): 999-1008.
-
(1996)
J Cell Sci
, vol.109
, Issue.5 PART
, pp. 999-1008
-
-
Yamazaki, T.1
Koo, E.H.2
Selkoe, D.J.3
-
42
-
-
0028213567
-
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth
-
Small DH, Nurcombe V, Reed G, et al. A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci 1994; 14(4): 2117-2127.
-
(1994)
J Neurosci
, vol.14
, Issue.4
, pp. 2117-2127
-
-
Small, D.H.1
Nurcombe, V.2
Reed, G.3
-
43
-
-
0027444745
-
Beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin
-
Kibbey MC, Jucker M, Weeks BS, Neve RL, Van Nostrand WE, Kleinman HK. beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. Proc Natl Acad Sci USA 1993; 90(21): 10150-10153.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.21
, pp. 10150-10153
-
-
Kibbey, M.C.1
Jucker, M.2
Weeks, B.S.3
Neve, R.L.4
Van Nostrand, W.E.5
Kleinman, H.K.6
-
44
-
-
0030030005
-
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I
-
Beher D, Hesse L, Masters CL, Multhaup G. Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J Biol Chem 1996; 271(3): 1613-1620.
-
(1996)
J Biol Chem
, vol.271
, Issue.3
, pp. 1613-1620
-
-
Beher, D.1
Hesse, L.2
Masters, C.L.3
Multhaup, G.4
-
45
-
-
1842364870
-
Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: Evidence for the participation of heparan sulfate proteoglycans
-
Caceres J, Brandan E. Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: Evidence for the participation of heparan sulfate proteoglycans. J Cell Biochem 1997; 65(2): 145-158.
-
(1997)
J Cell Biochem
, vol.65
, Issue.2
, pp. 145-158
-
-
Caceres, J.1
Brandan, E.2
-
46
-
-
0027254060
-
A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor
-
Miyazaki K, Hasegawa M, Funahashi K, Umeda M. A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature 1993; 362(6423): 839-841.
-
(1993)
Nature
, vol.362
, Issue.6423
, pp. 839-841
-
-
Miyazaki, K.1
Hasegawa, M.2
Funahashi, K.3
Umeda, M.4
-
47
-
-
0038052349
-
Novel processing of beta-amyloid precursor protein catalyzed by membrane type 1 matrix metalloproteinase releases a fragment lacking the inhibitor domain against gelatinase a
-
Higashi S, Miyazaki K. Novel processing of beta-amyloid precursor protein catalyzed by membrane type 1 matrix metalloproteinase releases a fragment lacking the inhibitor domain against gelatinase A. Biochemistry 2003; 42(21): 6514-6526.
-
(2003)
Biochemistry
, vol.42
, Issue.21
, pp. 6514-6526
-
-
Higashi, S.1
Miyazaki, K.2
-
48
-
-
0035823495
-
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease
-
Scheuermann S, Hambsch B, Hesse L, et al. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem 2001; 276(36): 33923-33929.
-
(2001)
J Biol Chem
, vol.276
, Issue.36
, pp. 33923-33929
-
-
Scheuermann, S.1
Hambsch, B.2
Hesse, L.3
-
49
-
-
0027447656
-
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)
-
Nishimoto I, Okamoto T, Matsuura Y, Okamoto T, Murayama Y, Ogata E. Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o). Nature 1993; 362: 75-79.
-
(1993)
Nature
, vol.362
, pp. 75-79
-
-
Nishimoto, I.1
Okamoto, T.2
Matsuura, Y.3
Okamoto, T.4
Murayama, Y.5
Ogata, E.6
-
50
-
-
0031717925
-
Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's β-amyloid precursor protein
-
Russo T, Faraonio R, Minopoli G, De Candia P, De Renzis S, Zambrano N. Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's β-amyloid precursor protein. FEBS Lett 1998; 434: 1-7.
-
(1998)
FEBS Lett
, vol.434
, pp. 1-7
-
-
Russo, T.1
Faraonio, R.2
Minopoli, G.3
De Candia, P.4
De Renzis, S.5
Zambrano, N.6
-
51
-
-
0032955868
-
A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein
-
Watanabe T, Sukegawa J, Sukegawa I, et al. A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein. J Neurochem 1999; 72: 549-556.
-
(1999)
J Neurochem
, vol.72
, pp. 549-556
-
-
Watanabe, T.1
Sukegawa, J.2
Sukegawa, I.3
-
52
-
-
0035816661
-
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X, Sudhof TC. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001; 293(5527): 115-120.
-
(2001)
Science
, vol.293
, Issue.5527
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
53
-
-
0036462590
-
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP)
-
Scheinfeld MH, Roncarati R, Vito P, Lopez PA, Abdallah M, D'Adamio L. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J Biol Chem 2002; 277(5): 3767-3775.
-
(2002)
J Biol Chem
, vol.277
, Issue.5
, pp. 3767-3775
-
-
Scheinfeld, M.H.1
Roncarati, R.2
Vito, P.3
Lopez, P.A.4
Abdallah, M.5
D'Adamio, L.6
-
54
-
-
0028988801
-
Beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
-
Zheng H, Jiang M, Trumbauer ME, et al. beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 1995; 81(4): 525-531.
-
(1995)
Cell
, vol.81
, Issue.4
, pp. 525-531
-
-
Zheng, H.1
Jiang, M.2
Trumbauer, M.E.3
-
55
-
-
0028295848
-
Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein
-
Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J 1994; 13(5): 1114-1122.
-
(1994)
EMBO J
, vol.13
, Issue.5
, pp. 1114-1122
-
-
Suzuki, T.1
Oishi, M.2
Marshak, D.R.3
Czernik, A.J.4
Nairn, A.C.5
Greengard, P.6
-
56
-
-
0030935325
-
Phosphorylation of Alzheimer beta-amyloid precursor-like proteins
-
Suzuki T, Ando K, Isohara T, et al. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry 1997; 36(15): 4643-4649.
-
(1997)
Biochemistry
, vol.36
, Issue.15
, pp. 4643-4649
-
-
Suzuki, T.1
Ando, K.2
Isohara, T.3
-
57
-
-
0032053984
-
Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
-
Nishimura I, Uetsuki T, Dani SU, et al. Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer. J Neurosci 1998; 18(7): 2387-2398.
-
(1998)
J Neurosci
, vol.18
, Issue.7
, pp. 2387-2398
-
-
Nishimura, I.1
Uetsuki, T.2
Dani, S.U.3
-
58
-
-
0034029430
-
A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis
-
Rohn TT, Ivins KJ, Bahr BA, Cotman CW, Cribbs DH. A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J Neurochem 2000; 74(6): 2331-2342.
-
(2000)
J Neurochem
, vol.74
, Issue.6
, pp. 2331-2342
-
-
Rohn, T.T.1
Ivins, K.J.2
Bahr, B.A.3
Cotman, C.W.4
Cribbs, D.H.5
-
59
-
-
0021956826
-
Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
-
Wisniewski KE, Wisniewski HM, Wen GY. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 1985; 17(3): 278-282.
-
(1985)
Ann Neurol
, vol.17
, Issue.3
, pp. 278-282
-
-
Wisniewski, K.E.1
Wisniewski, H.M.2
Wen, G.Y.3
-
60
-
-
0029932417
-
Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties
-
Bouillot C, Prochiantz A, Rougon G, Allinquant B. Axonal amyloid precursor protein expressed by neurons in vitro is present in a membrane fraction with caveolae-like properties. J Biol Chem 1996; 271(13): 7640-7644.
-
(1996)
J Biol Chem
, vol.271
, Issue.13
, pp. 7640-7644
-
-
Bouillot, C.1
Prochiantz, A.2
Rougon, G.3
Allinquant, B.4
-
61
-
-
0035928732
-
Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
-
Riddell DR, Christie G, Hussam I, Dingwall C. Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr Biol 2001; 11(16): 1288-1293.
-
(2001)
Curr Biol
, vol.11
, Issue.16
, pp. 1288-1293
-
-
Riddell, D.R.1
Christie, G.2
Hussam, I.3
Dingwall, C.4
-
62
-
-
0031746979
-
A detergent-insoluble membrane compartment contains a beta in vivo
-
Lee SJ, Liyanage U, Bickel PE, Xia W, Lansbury PT Jr, Kosik KS. A detergent-insoluble membrane compartment contains A beta in vivo. Nat Med 1998; 4(6): 730-4.
-
(1998)
Nat Med
, vol.4
, Issue.6
, pp. 730-734
-
-
Lee, S.J.1
Liyanage, U.2
Bickel, P.E.3
Xia, W.4
Lansbury Jr., P.T.5
Kosik, K.S.6
-
63
-
-
0032568552
-
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
-
Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 1998; 95(11): 6460-6464.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.11
, pp. 6460-6464
-
-
Simons, M.1
Keller, P.2
De Strooper, B.3
Beyreuther, K.4
Dotti, C.G.5
Simons, K.6
-
64
-
-
0036674082
-
Lipid rafts play an important role in a beta biogenesis by regulating the beta-secretase pathway
-
Tun H, Marlow L, Pinnix I, Kinsey R, Sambamurti K. Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway. J Mol Neurosci 2002; 19(1/2): 31-35.
-
(2002)
J Mol Neurosci
, vol.19
, Issue.1-2
, pp. 31-35
-
-
Tun, H.1
Marlow, L.2
Pinnix, I.3
Kinsey, R.4
Sambamurti, K.5
-
65
-
-
0037421206
-
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
-
Ehehalt R, Keller P, Haass C, Thiele C, Simons K. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol 2003; 160(1): 113-123.
-
(2003)
J Cell Biol
, vol.160
, Issue.1
, pp. 113-123
-
-
Ehehalt, R.1
Keller, P.2
Haass, C.3
Thiele, C.4
Simons, K.5
-
66
-
-
0034117282
-
Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha
-
Read MA, Brownell JE, Gladysheva TB, et al. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. Mol Cell Biol 2000; 20(7): 2326-2333.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.7
, pp. 2326-2333
-
-
Read, M.A.1
Brownell, J.E.2
Gladysheva, T.B.3
-
67
-
-
0036195134
-
An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
-
Ohh M, Kim WY, Moslehi JJ, et al. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. EMBO Rep 2002; 3(2): 177-182.
-
(2002)
EMBO Rep
, vol.3
, Issue.2
, pp. 177-182
-
-
Ohh, M.1
Kim, W.Y.2
Moslehi, J.J.3
-
68
-
-
0037144438
-
Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression
-
Bruni P, Minopoli G, Brancaccio T, et al. Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. J Biol Chem 2002; 277(38): 35481-35488.
-
(2002)
J Biol Chem
, vol.277
, Issue.38
, pp. 35481-35488
-
-
Bruni, P.1
Minopoli, G.2
Brancaccio, T.3
-
69
-
-
0032541337
-
APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells
-
Rassoulzadegan M, Yang Y, Cuzin F. APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells. EMBO J 1998; 17(16): 4647-4656.
-
(1998)
EMBO J
, vol.17
, Issue.16
, pp. 4647-4656
-
-
Rassoulzadegan, M.1
Yang, Y.2
Cuzin, F.3
-
70
-
-
0035943345
-
A portrait of Alzheimer secretases-New features and familiar faces
-
Esler WP, Wolfe MS. A portrait of Alzheimer secretases-New features and familiar faces. Science 2001; 293(5534): 1449-1454.
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1449-1454
-
-
Esler, W.P.1
Wolfe, M.S.2
-
71
-
-
1442306058
-
Binding of F-spondin to amyloid-{beta} precursor protein: A candidate amyloid-{beta} precursor protein ligand that modulates amyloid-{beta} precursor protein cleavage
-
Ho A, Sudhof TC. Binding of F-spondin to amyloid-{beta} precursor protein: A candidate amyloid-{beta} precursor protein ligand that modulates amyloid-{beta} precursor protein cleavage. Proc Natl Acad Sci USA 2004; 101(8): 2548-2553.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.8
, pp. 2548-2553
-
-
Ho, A.1
Sudhof, T.C.2
-
72
-
-
0031866596
-
Direct association of presenilin-1 with beta-catenin
-
Murayama M, Tanaka S, Palacino J, et al. Direct association of presenilin-1 with beta-catenin. FEBS Lett 1998; 433(1/2): 73-77.
-
(1998)
FEBS Lett
, vol.433
, Issue.1-2
, pp. 73-77
-
-
Murayama, M.1
Tanaka, S.2
Palacino, J.3
-
73
-
-
0032568821
-
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
-
Yu G, Chen F, Levesque G, et al. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J Biol Chem 1998; 273(26): 16470-16475.
-
(1998)
J Biol Chem
, vol.273
, Issue.26
, pp. 16470-16475
-
-
Yu, G.1
Chen, F.2
Levesque, G.3
-
74
-
-
1542347695
-
Convergence of Wnt, β-catenin, and cadherin pathways
-
Nelson WJ, Nusse R. Convergence of Wnt, β-catenin, and cadherin pathways. Science 2004; 303: 1483-1487.
-
(2004)
Science
, vol.303
, pp. 1483-1487
-
-
Nelson, W.J.1
Nusse, R.2
-
75
-
-
0032531793
-
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
-
Zhang Z, Hartmann H, Do VM, et al. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 1998; 395(6703): 698-702.
-
(1998)
Nature
, vol.395
, Issue.6703
, pp. 698-702
-
-
Zhang, Z.1
Hartmann, H.2
Do, V.M.3
-
76
-
-
0035845481
-
Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis
-
Xia X, Qian S, Soriano S, et al. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci USA 2001; 98(19): 10863-10868.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.19
, pp. 10863-10868
-
-
Xia, X.1
Qian, S.2
Soriano, S.3
-
77
-
-
0141429160
-
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations
-
Marambaud P, Wen PH, Dutt A, et al. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 2003; 114(5): 635-645.
-
(2003)
Cell
, vol.114
, Issue.5
, pp. 635-645
-
-
Marambaud, P.1
Wen, P.H.2
Dutt, A.3
-
78
-
-
0035930522
-
Presenilin 1 independently regulates β-catenin stability and transcriptional activity
-
Killick R, Pollard CC, Asuni AA, et al. Presenilin 1 independently regulates β-catenin stability and transcriptional activity. J Biol Chem 2001; 276(51): 48554-48561.
-
(2001)
J Biol Chem
, vol.276
, Issue.51
, pp. 48554-48561
-
-
Killick, R.1
Pollard, C.C.2
Asuni, A.A.3
-
79
-
-
0037145062
-
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis
-
Kang DE, Soriano S, Xia X, et al. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: Implications for beta-catenin activation in tumorigenesis. Cell 2002; 110(6): 751-762.
-
(2002)
Cell
, vol.110
, Issue.6
, pp. 751-762
-
-
Kang, D.E.1
Soriano, S.2
Xia, X.3
-
80
-
-
0035933518
-
Presenilin 1 mutations increase amyloid precursor protein production and proteolysis in Xenopus laevis oocytes
-
Heyn SN, Vulliet PR. Presenilin 1 mutations increase amyloid precursor protein production and proteolysis in Xenopus laevis oocytes. Brain Res 2001; 904(2): 189-198.
-
(2001)
Brain Res
, vol.904
, Issue.2
, pp. 189-198
-
-
Heyn, S.N.1
Vulliet, P.R.2
-
81
-
-
0025369198
-
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)
-
van Broeckhoven C, Haan J, Bakker E, et al. Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science 1990; 248(4959): 1120-1122.
-
(1990)
Science
, vol.248
, Issue.4959
, pp. 1120-1122
-
-
Van Broeckhoven, C.1
Haan, J.2
Bakker, E.3
-
82
-
-
0034982951
-
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
-
Grabowski TJ, Cho HS, Vonsattel JP, Rebeck GW, Greenberg SM. Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol 2001; 49(6): 697-705.
-
(2001)
Ann Neurol
, vol.49
, Issue.6
, pp. 697-705
-
-
Grabowski, T.J.1
Cho, H.S.2
Vonsattel, J.P.3
Rebeck, G.W.4
Greenberg, S.M.5
-
83
-
-
0033588412
-
The role of beta-catenin stability in mutant PS1-associated apoptosis
-
Weihl CC, Miller RJ, Roos RP. The role of beta-catenin stability in mutant PS1-associated apoptosis. Neuroreport 1999; 10(12): 2527-2532.
-
(1999)
Neuroreport
, vol.10
, Issue.12
, pp. 2527-2532
-
-
Weihl, C.C.1
Miller, R.J.2
Roos, R.P.3
-
84
-
-
0344668728
-
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
-
Ertekin-Taner N, Ronald J, Asahara H, et al. Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Hum Mol Genet 2003; 12(23): 3133-3143.
-
(2003)
Hum Mol Genet
, vol.12
, Issue.23
, pp. 3133-3143
-
-
Ertekin-Taner, N.1
Ronald, J.2
Asahara, H.3
-
85
-
-
0035936807
-
Hyper-prohferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin
-
Vasioukhin V, Bauer C, Degenstein L, Wise B, Fuchs E. Hyper-prohferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 2001; 104(4): 605-617.
-
(2001)
Cell
, vol.104
, Issue.4
, pp. 605-617
-
-
Vasioukhin, V.1
Bauer, C.2
Degenstein, L.3
Wise, B.4
Fuchs, E.5
-
86
-
-
0038359353
-
Caught up in a Wnt storm: Wnt signaling in cancer
-
Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 2003; 1653(1): 1-24.
-
(2003)
Biochim Biophys Acta
, vol.1653
, Issue.1
, pp. 1-24
-
-
Giles, R.H.1
Van Es, J.H.2
Clevers, H.3
-
87
-
-
0037135177
-
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
-
Chenn A, Walsh CA. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 2002; 297(5580): 365-369.
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 365-369
-
-
Chenn, A.1
Walsh, C.A.2
-
88
-
-
0035034474
-
Ontogenetic changes in protein level of amyloid precursor protein (APP) in growth cones and synaptosomes from rat brain and prenatal expression pattern of APP mRNA isoforms in developing rat embryo
-
Kirazov E, Kirazov L, Bigl V, Schliebs R. Ontogenetic changes in protein level of amyloid precursor protein (APP) in growth cones and synaptosomes from rat brain and prenatal expression pattern of APP mRNA isoforms in developing rat embryo. Int J Dev Neurosci 2001; 19(3): 287-296.
-
(2001)
Int J Dev Neurosci
, vol.19
, Issue.3
, pp. 287-296
-
-
Kirazov, E.1
Kirazov, L.2
Bigl, V.3
Schliebs, R.4
-
89
-
-
0037106090
-
Stem cell biology of the central nervous system
-
Okano H. Stem cell biology of the central nervous system. J Neurosci Res 2002; 69: 698-707.
-
(2002)
J Neurosci Res
, vol.69
, pp. 698-707
-
-
Okano, H.1
-
90
-
-
0043135185
-
DNA synthesis and neuronal apoptosis caused by familia Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3
-
McPhie DL, Coopersmith R, Hines-Peratta A, Chen Ivins KJ, Manly SP, Kozlowski MR, Neve KA, Neve RL. DNA synthesis and neuronal apoptosis caused by familia Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. J Neurosci 2003; 23: 6914-6927.
-
(2003)
J Neurosci
, vol.23
, pp. 6914-6927
-
-
McPhie, D.L.1
Coopersmith, R.2
Hines-Peratta, A.3
Chen Ivins, K.J.4
Manly, S.P.5
Kozlowski, M.R.6
Neve, K.A.7
Neve, R.L.8
-
91
-
-
0029003699
-
Cell adhesion and signal transduction: The Armadillo connection
-
Peifer M. Cell adhesion and signal transduction: The Armadillo connection. Trends Cell Biol 1995; 5: 224-229.
-
(1995)
Trends Cell Biol
, vol.5
, pp. 224-229
-
-
Peifer, M.1
|