Akt activity in presenilin 1 wild-type and mutation transfected human SH-SY5Y neuroblastoma cells after serum deprivation and high glucose stress

Journal of Neuroscience Research

Volumn 66, Issue 3, 2001, Pages 448-456

  Vestling, Monika ^a   Wiehager, Birgitta ^a   Tanii, Hisashi ^b   Cowburn, Richard F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Akt protein kinase B; Alzheimer disease; Apoptosis; IGF I; Presenilin

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GLUCOSE; PHOSPHATIDYLINOSITOL 3 KINASE; PRESENILIN 1; PRESENILIN 2; PROTEIN KINASE B; SOMATOMEDIN C;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EXON; GENE DELETION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; SERUM; STRESS;

ALZHEIMER DISEASE; APOPTOSIS; BLOOD PROTEINS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; DOWN-REGULATION; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOBLOTTING; INSULIN-LIKE GROWTH FACTOR I; MEMBRANE PROTEINS; MUTATION; NEUROBLASTOMA; NEURONS; PHOSPHORYLATION; PRESENILIN-1; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STRESS; TRANSFECTION;

EID: 0035498809     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10006     Document Type: Article

References (58)

1. Presenilin 1 protein interacts with Bcl-2
2. Mechanism of activation of protein kinase B by insulin and IGF-1
3. Purification and characterization of a phosphatidylinositol 3,4,5 triphosphate dependent protein kinase (PDK1) that phosphorylates and activates protein kinase B
4. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
5. Regulation of cell death protease caspase-9 by phosphorylation
6. Wingless inactivates glycogen synthase kinase-3 via an intracellular signaling pathway which involves a protein kinase C
7. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
8. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
9. Cellular survival: A play in three Akts
10. Cholinergic- and stress-induced signaling activities in cells overexpressing wild-type and mutant presenilin-1
11. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
12. Insulin-like growth factor-I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity
13. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
14. Insulin-like growth factors regulate neuronal differentiation and survival
15. Differential regulation of glycogen synthase kinase-3β by protein kinase C isotypes
16. Alzheimer PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide
17. Alzheimer presenilin mutation sensitizes neural cells to apoptosis induced by tropic factor withdrawal and amyloid β-peptide: Involvement of calcium and oxyradicals
18. Glycogen synthase kinase-3 induces Alzheimer disease-like phosphorylation of tau: Generation of paired filament epitopes and neuronal localization of the kinase
19. Amyloid, the presenilins and Alzheimer disease
20. Role of glycogen synthase kinase-3β in neuronal apoptosis induced by trophic withdrawal
21. Increased apoptosis arising from increased expression of the Alzheimer disease-associated presenilin-2 mutation (N141I)
22. Induction of NF-κB by the Akt/PKB kinase
23. Presenilin 1 facilitates the constitutive turnover of β-catenin: Differential activity of Alzheimer disease-linked PS1 mutants in the β-catenin-signaling pathway
24. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production
25. Negative regulation of the SAPK/JNK signaling pathway by presenilin 1
26. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin
27. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3β
28. Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3 β conditional transgenic mice
29. Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer disease hippocampus
30. Insulin-like growth factor I rescues SH-SY5Y human neuroblastoma cells from hyperosmotic induced programmed cell death
31. Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose
32. Increased Aβ42(43) from cell lines expressing presenilin 1 mutations
33. Direct association of presenilin-1 with β-catenin
34. Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex
35. Signaling through β-catenin and Lef/Tcf
36. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
37. Amyloid β peptide of Alzheimer disease downregulates bcl-2 and upregulates bax expression in human neurons
38. L gene product
39. Insulin-like growth factor-1 inhibits apoptosis using the phosphatidyl-inositol 3′ kinase pathway and the MAP kinase pathway
40. L
41. Distribution, levels and activity of glycogen synthase kinase-3 in the Alzheimer disease brain
42. Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes
43. Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A23187 in neuroblastoma cells
44. Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer disease brain increases with disease severity
45. Type I insulin-like growth factor receptor activation regulates apoptotic proteins
46. Mitogen activation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation
47. Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
48. Alzheimer disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis
49. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
50. Bcl-2 and Bax protein expression in Alzheimer disease
51. Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis
52. 2+-binding protein ALG-2 and Alzheimer disease gene ALG-3
53. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB
54. The role of β-catenin stability in mutant PS1-associated apoptosis
55. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation
56. Regulation of apoptosis by presenilin 1
57. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin
58. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis