The GSK3β signaling cascade and neurodegenerative disease

Current Opinion in Neurobiology

Volumn 12, Issue 3, 2002, Pages 275-278

  Kaytor, Michael D ^a   Orr, Harry T ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA;

ALZHEIMER DISEASE; APOPTOSIS; BIOCHEMISTRY; CELL FUNCTION; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENZYME ANALYSIS; ENZYME REGULATION; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENILE PLAQUE; SIGNAL TRANSDUCTION;

EID: 0036606693     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(02)00320-3     Document Type: Review

References (29)

1. GSK3 takes centre stage more than 20 years after its discovery
2. Developmental expression and localization of glycogen synthase-3β in rat brain
3. Crystal structure of glycogen synthase kinase 3β: Structural basis for phosphate-primed substrate specificity and autoinhibition
4. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation
5. Regulation of neuronal survival by the serine-threonine protein kinase Akt
6. Transient increases in intracellular calcium result in prolonged site-selective increases in tau phosphorylation through a glycogen synthase kinase 3β-dependent pathway
7. Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration
8. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway
9. Glycogen synthase kinase-3β facilitates staurosparine- and heat shock-induced apoptosis. Protection by lithium
10. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death
11. Role of glycogen synthase kinase-3β in neuronal apoptosis induced by trophic withdrawal
12. Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice
13. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
14. Candidate gene for the chromosome 1 familial Alzheimer's disease locus
15. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolytic and γ-secretase activity
16. Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments
17. Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the inactivation of phosphatidylinositol-3 kinase and the activation of tau protein kinase 1/glycogen synthase kinase-3β
18. Activation of tau protein kinase 1/glycogen synthase-3β by amyloid β peptide (25-35) enhances phosphorylation of tau in hippocampal neurons
19. Lithium protects cultured neurons against β-amyloid-induced neurodegeneration
20. Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer disease neurofibrillary changes
21. GSK3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces tau dephosphorylation and β-catenin stabilisation without elevation of glycogen synthase activity
22. Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
23. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB
24. Nuclear export of NFATc enhanced by glycogen synthase kinase-3
25. Glycogen synthase kinase 3β negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1
26. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
27. Glycogen synthase kinase 3β and extracellular signal-regulated kinase inactivate heat shock transcription factor 1 by facilitating the disappearance of transcriptionally active granules after heat shock
28. Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge
29. Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3β