SHP-2 Regulates the Phosphatidylinositide 3′-Kinase/Akt Pathway and Suppresses Caspase 3-Mediated Apoptosis

Journal of Cellular Physiology

Volumn 199, Issue 2, 2004, Pages 227-236

  Zito, Christina Ivins ^a   Kontaridis, Maria I ^a,c   Fornaro, Mara ^a   Feng, Geng Shen ^b   Bennett, Anton M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; ETOPOSIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SH2; PROTEIN TYROSINE PHOSPHATASE SHP 2; SOMATOMEDIN C;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CATALYSIS; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXON; FIBROBLAST; GENE DELETION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; ENZYME ACTIVATION; ETOPOSIDE; FIBROBLASTS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NUCLEIC ACID SYNTHESIS INHIBITORS; PRECIPITIN TESTS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SOMATOMEDINS; SRC HOMOLOGY DOMAINS; TRANSFECTION;

EID: 1842525884     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10446     Document Type: Article

References (40)

1. Allard JD, Herbst R, Carroll PM, Simon MA. 1998. Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase corkscrew. J Biol Chem 273(21):13129-13135.
2. Backer JM, Myers MG, Shoelson SE, Chin DJ, Sun X-J, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, White M. 1992. Phosphotidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 11(9):3469-3479.
3. Ballif BA, Blenis J. 2001. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ 12(8):397-408.
4. Barford D, Neel BG. 1998. Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2. Structure 6(3):249-254.
5. Bennett AM, Tang TL, Sugimoto S, Walsh CT, Neel BG. 1994. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor β to Ras. Proc Natl Acad Sci USA 91:7335-7339.
6. Bennett AM, Hausdorff SF, O'Reilly AM, Freeman RM, Neel BG. 1996. Multiple requirements for SHPTP2 in epidermal growth factor mediated cell cycle progression. Mol Cell Biol 16:1189-1202.
7. Bjorbak C, Buchholz RM, Davis SM, Bates SH, Pierroz DD, Gu H, Neel BG, Myers MG, Jr., Flier JS. 2001. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 276(7):4747-4755.
8. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. 1999. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286(5443):1358-1362.
9. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282(5392):1318-1321.
10. Chen R, Kim O, Yang J, Sato K, Eisenmann KM, McCarthy J, Chen H, Qiu Y. 2001. Regulation of Akt/PKB activation by tyrosine phosphorylation. J Biol Chem 276(34):31858-31862.
11. Conus NM, Hannan KM, Cristiano BE, Hemmings BA, Pearson RB. 2002. Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase. J Biol Chem 277(41):38021-38028.
12. Datta K, Bellacosa A, Chan TO, Tsichlis PN. 1996. Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. J Biol Chem 271(48):30835-30839.
13. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91(2):231-241.
14. Datta SR, Brunet A, Greenberg ME. 1999. Cellular survival: A play in three Akts. Genes Dev 13(22):2905-2927.
15. Gutch MJ, Flint AJ, Keller J, Tonks NK, Hengartner MO. 1998. The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Genes Dev 12(4):571-585.
16. Hakak Y, Hsu YS, Martin GS. 2000. Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt. Oncogene 19(28):3164-3171.
17. Jost M, Huggett TM, Kari C, Boise LH, Rodeck U. 2001. Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway. J Biol Chem 276(9):6320-6326.
18. Kontaridis MI, Liu X, Zhang L, Bennett AM. 2002. Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Mol Cell Biol 22(11):3875-3891.
19. Li W, Nishimura R, Kashishan A, Batzer AG, Kim WJH, Cooper JA, Schlessinger J. 1993. A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol 14:509-517.
20. Myers MGJ, Mendez R, Shi P, Pierce JH, Rhoads R, White MF. 1998. The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J Biol Chem 273:26908-26914.
21. Neel BG, Tonks NK. 1997. Protein tyrosine phosphatases in signal transduction. Curr Opin Cell Biol 9(2):193-204.
22. Noguchi T, Matozaki T, Horita K, Fujioka Y, Kasuga M. 1994. Role of SH-PTP2, a protein-tyrosine phosphatase with src homology 2 domains, in insulin-stimulated ras activation. Mol Cell Biol 14:6674-6682.
23. Parrizas M, Saltiel AR, LeRoith D. 1997. Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways. J Biol Chem 272(1):154-161.
24. Pear WS, Nolan GP, Scott ML. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 90:8392-8396.
25. Perkins LA, Johnson MR, Melnick MB, Perrimon N. 1996. The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev Biol 180(1):63-81.
26. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. 1994. Phosphotidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532.
27. Saxton TM, Henkemeyer M, Gasca S, Shen R, Rossi DJ, Shalaby F, Feng GS, Pawson T. 1997. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J 16(9):2352-2364.
28. Saxton TM, Ciruna BG, Holmyard D, Kulkarni S, Harpal K, Rossant J, Pawson T. 2000. The SH2 tyrosine phosphatase shp-2 is required for mammalian limb development. Nat Genet 24(4):420-423.
29. Shi Y. 2002. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9:459-470.
30. Shi ZQ, Lu W, Feng GS. 1998. The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J Biol Chem 273(9):4904-4908.
31. Shi ZQ, Yu DH, Park M, Marshall M, Feng GS. 2000. Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity. Mol Cell Biol 20(5):1526-1536.
32. Tonks NK, Neel BG. 2001. Combinatorial control of the specificity of protein tyrosine phosphatases. Curr Opin Cell Biol 13(2):182-195.
33. Van Vactor D, O'Reilly AM, Neel BG. 1998. Genetic analysis of protein tyrosine phosphatases. Curr Opin Genet Dev 8(1):112-126.
34. Walter AO, Peng ZY, Cartwright CA. 1999. The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism. Oncogene 18(11):1911-1920.
35. Wu CJ, O'Rourke DM, Feng GS, Johnson GR, Wang Q, Greene MI. 2001. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors. Oncogene 20(42):6018-6025.
36. Yamauchi K, Milarski KL, Saltiel AR, Pessin JE. 1995. Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc Natl Acad Sci USA 92:664-668.
37. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. 1997. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 275(5303):1129-1132.
38. Yart A, Laffargue M, Mayeux P, Chretien S, Peres C, Tonks N, Roche S, Payrastre B, Chap H, Raynal P. 2001. A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor. J Biol Chem 276(12):8856-8864.
39. Yuan L, Yu W-M, Yuan Z, Haudenschild CC, Qu C-K. 2003. Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response. J Biol Chem 278(17):15208-15216.
40. Zhang SQ, Tsiaras WG, Araki T, Wen G, Minichiello L, Klein R, Neel BG. 2002. Receptor-specific regulation of phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2. Mol Cell Biol 22(12):4062-4072.