Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1

Journal of Neurochemistry

Volumn 82, Issue 2, 2002, Pages 353-364

  Takai, Satomi ^a   Yamada, Masashi ^a   Araki, Toshiyuki ^a,b   Koshimizu, Hisatsugu ^a   Nawa, Hiroyuki ^b   Hatanaka, Hiroshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Adenovirus vector; Neurotrophic factor; Neurotrophin; Parkinson's disease; Protein tyrosine phosphatase; Trk

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; IMMUNOGLOBULIN; MUTANT PROTEIN; PHENYLALANINE; PHOSPHATASE; PROTEIN SHPS 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; TYROSINE; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DEPHOSPHORYLATION; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEFICIENCY; MESENCEPHALON; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VIRUS RECOMBINANT; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, DIFFERENTIATION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CELLS, CULTURED; DOPAMINE; ENZYME INHIBITORS; FEMALE; GENETIC VECTORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE GLYCOPROTEINS; MESENCEPHALON; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS, SITE-DIRECTED; NEURAL CELL ADHESION MOLECULE L1; NEURAL CELL ADHESION MOLECULES; NEURONS; PHOSPHORYLATION; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC;

ADENOVIRIDAE; ANIMALIA;

EID: 0036068404     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00960.x     Document Type: Article

References (63)

1. PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation
2. Shp-2 specially regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons
3. BIT/SHPS-1 enhances brain-derived neurotrophic factor-promoted neuronal survival in cultured cerebral cortical neurons
4. Neurotrophic factors and their receptors
5. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression
6. Protein-tyrosine-phosphatase SHPTP2 couples platelet derived growth factor receptor beta to Ras
7. Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: Signal transduction cascades and site of ethanol action
8. Functional interactions of neurotrophins and neurotrophin receptors
9. Neurotrophins in the pathogenesis and potential treatment of Parkinson's disease
10. Central nervous system antigen P84 can serve as a substrate for neurite outgrowth
11. The SH2 domain-containing tyrosine phosphatase PTP1D is required for inteferon alpha/beta-induced gene expression
12. Basic fibroblast growth factor rescues CNS neurons from cell death caused by high oxygen atmosphere in culture
13. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
14. Identification of a human src homology 2-containing protein-tyrosine phosphatase: A putative homolog of Drosophila Corkscrew
15. A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhension
16. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
17. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
18. Monoclonal antibody to tyrosine hydroxylase from rat pheochromocytoma PC12h cells with special reference to nerve growth factor-mediated increase of immunoprecipitable enzymes
19. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
20. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
21. Overlapping and distinct actions of the neurotrophins BDNF, NT-3 and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon
22. A simple and efficient method for purification of infectious recombinant adenovirus
23. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
24. Neurotrophin signal transduction in the nervous system
25. Adapter functions of protein-tyrosine phosphatase ID in insulin receptor/insulin receptor substrate-1 interaction
26. A family of proteins that inhibit signaling through tyrosine kinase receptor
27. Expression of CD47/IAP induces death of cultured cerebral cortical neurons
28. The insulin receptor substrate 1 associates with the SH2-containing phosphatyrosine phosphatase Syp
29. An adenovirus vector for gene transfer into neurons and glia in the brain
30. Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2
31. A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase
32. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
33. Protein tyrosine phosphatase in signal transduction
34. Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
35. Efficient selection for high-expression transfectants with a novel eukaryotic vector
36. Expression of trkB and trkC mRNAs by adult midbrain dopamine neurons: A double-label in situ hybridization study
37. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps
38. Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine based activation motif of a novel brain molecule
39. Tyrosine phosphorylation and association of BIT with SHP-2 induced by neurotrophins
40. Trk receptors: Mediators of neurotrophin action
41. Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso
42. Isolation of a src homology 2-containing tyrosine phosphatase
43. The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinases and G protein-coupled receptors
44. BIT, an immuno antigen receptor-like molecule in the brain
45. Intracellular signaling pathways activated by neurotrophic factors
46. A proteintyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases
47. +-induced apoptosis of cerebellar granule neurons
48. Neurotrophic factors in Alzheimer's and Parkinson's disease brain
49. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB2, HCP, SHC, Syk, and Vav
50. SHP-2, SH2-containing protein tyrosine phosphatase-2
51. Localization and subcellular distribution of SH-PTP2, a protein-tyrosine phosphatase with Src homology-2 domains, in rat brain
52. Roles of the complex formation of SHPS-1 with SHP-2 in insulinstimulated mitogen-activated protein kinase activation
53. The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
54. Involvement of SH-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathway
55. Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages
56. Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Role of Fak and Src family kinases
57. Genetic analysis of protein tyrosine phosphatase
58. Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induced tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3-kinase
59. A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation
60. Brain-derived neurotrophic factor stimulates interactions of Shp-2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons
61. Differences in survival promoting effects and intracellular signaling properties of BDNF and IGF-1 in cultured cerebral cortical neurons
62. Protein tyrosine phosphatase containing SH2 domains: Characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13
63. Molecular characterization of domains required for the specific interactions between Shp-2 phosphatase and JAK tyrosine kinase