The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition

Acta Crystallographica Section D: Biological Crystallography

Volumn 61, Issue 10, 2005, Pages 1320-1334

  Finer Moore, Janet S ^a   Anderson, Amy C ^b   O'Neil, Robert H ^b   Costi, M Paola ^c   Ferrari, Stefania ^c   Krucinski, Jolanta ^a   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Dartmouth College   (United States)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; FILOBASIDIELLA NEOFORMANS;

LIGAND; THYMIDYLATE SYNTHASE;

ALGORITHM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; CONFORMATION; CRYPTOCOCCUS NEOFORMANS; DIMERIZATION; DRUG DESIGN; ENZYMOLOGY; ESCHERICHIA COLI; GENE DELETION; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; AMINO ACID SEQUENCE; BINDING SITES; CRYPTOCOCCUS NEOFORMANS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; ESCHERICHIA COLI; GENE DELETION; HUMANS; KINETICS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SOFTWARE; SPECIES SPECIFICITY; TEMPERATURE; THYMIDYLATE SYNTHASE;

EID: 32944478374     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444905022638     Document Type: Article

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