Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

Journal of Medicinal Chemistry

Volumn 42, Issue 12, 1999, Pages 2112-2124

  Costi, Paola M ^a   Rinaldi, Marcella ^a   Tondi, Donatella ^a   Pecorari, Piergiorgio ^a   Barlocco, Daniela ^b   Ghelli, Stefano ^a   Stroud, Robert M ^c   Santi, Daniel V ^c   Stout, Thomas J ^c   Musiu, Chiara ^d   Marangiu, Elena M ^d   Pani, Alessandra ^d   Congiu, Donatella ^d   Loi, Giulia A ^d   La Colla, Paolo ^d  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; 2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; 3 HYDROXY 3 (3 CHLORO 4 HYDROXYPHENYL) 6 NITRO 1H,3H NAPHTHO[1,8 C,D]PYRAN 1 ONE; PHENOLPHTHALEIN; PHTHALEIN; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYPTOCOCCUS NEOFORMANS; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; LACTOBACILLUS CASEI; PNEUMOCYSTIS CARINII;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CELL LINE; CHLOROPHENOLS; CHROMONES; CRYPTOCOCCUS NEOFORMANS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; GRAM-POSITIVE BACTERIA; HUMANS; LACTOBACILLUS CASEI; MODELS, MOLECULAR; PHENOLPHTHALEIN; PNEUMOCYSTIS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE;

EID: 0033577983     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9900016     Document Type: Article

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