The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 Å resolution: Implications for a new mode of inhibition

Structure

Volumn 4, Issue 1, 1996, Pages 67-77

  Stout, Thomas J ^a   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti cancer; BW1843U89; Drug design; Folate analogues; Protein ligand interactions

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; 2'-DEOXYURIDYLIC ACID; ANTINEOPLASTIC AGENT; DEOXYURIDINE PHOSPHATE; ENZYME INHIBITOR; FOLIC ACID ANTAGONIST; INDOLE DERIVATIVE; QUINAZOLINE DERIVATIVE; THYMIDYLATE SYNTHASE;

ARTICLE; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ESCHERICHIA COLI; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY; CANCER;

ANTINEOPLASTIC AGENTS; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; QUINAZOLINES; THYMIDYLATE SYNTHASE;

EID: 0029643784     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(96)00010-X     Document Type: Article

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