Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase

Chemistry and Biology

Volumn 8, Issue 10, 2001, Pages 981-995

  Fritz, Timothy A ^a   Tondi, Donatella ^b   Finer Moore, Janet S ^a   Costi, M Paola ^b   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Enzyme specificity; Protein plasticity; Structure based drug design; Thymidylate synthase

Indexed keywords

DANSYL CHLORIDE; DEOXYURIDINE PHOSPHATE; DRUG DERIVATIVE; ENZYME INHIBITOR; N,O DIDANSYL L TYROSINE; N,O-DIDANSYL-L-TYROSINE; THYMIDYLATE SYNTHASE; TYROSINE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; DRUG ANTAGONISM; DRUG DESIGN; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; HUMAN; PROTEIN CONFORMATION; SYNTHESIS; X RAY DIFFRACTION;

CRYSTALLIZATION; DANSYL COMPOUNDS; DEOXYURACIL NUCLEOTIDES; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THYMIDYLATE SYNTHASE; TYROSINE; X-RAY DIFFRACTION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LACTOBACILLUS CASEI;

EID: 0034813214     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00067-9     Document Type: Article

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