Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 16, 2003, Pages 9173-9178

  Miallau, Linda ^a,b   Alphey, Magnus S ^a   Kemp, Lauris E ^a   Leonard, Gordon A ^b   McSweeney, Sean M ^b   Hecht, Stefan ^c   Bacher, Adelbert ^c   Eisenreich, Wolfgang ^c   Rohdich, Felix ^c   Hunter, William N ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Enzyme mechanism; Galactose kinase homoserine kinase mevalonate kinase phosphomevalonate kinase; Nonmevalonate; Phosphorylation

Indexed keywords

4 DIPHOSPHOCYTIDYL 2C METHYL DEXTRO ERYTHRITOL KINASE; ADENOSINE TRIPHOSPHATE; ANTIINFECTIVE AGENT; DIMETHYLALLYL DIPHOSPHATE; GALACTOSE KINASE; HOMOSERINE KINASE; ISOPENTYL DIPHOSPHATE; ISOPRENOID; MEVALONATE KINASE; PHOSPHOMEVALONATE KINASE; PHOSPHOTRANSFERASE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBUNIT; ESCHERICHIA COLI; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; SPECIES;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TEMPERATURE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; NEGIBACTERIA;

EID: 0042424807     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1533425100     Document Type: Article

References (63)

1. Sacchettini, J. C. & Poulter, C. D. (1997) Science 277, 1788-1789.
2. Rohmer, M. (1999) in Comprehensive Natural Products Chemistry: Isoprenoids Including Carotenoids and Sterols, ed. Cane, D. (Elsevier, Amsterdam), Vol. 2, pp. 45-67.
3. Beytia, E. D. & Porter, J. W. (1976) Annu. Rev. Biochem. 45, 113-142.
4. Edwards, P. A. & Ericsson, J. (1999) Annu. Rev. Biochem. 68, 157-185.
5. Boucher, Y. & Doolittle, W. F. (2000) Mol. Microbiol. 37, 703-716.
6. Kuzuyama, T. (2002) Biosci. Biotechnol. Biochem. 66, 1619-1627.
7. Lange, B. M., Rujan, T., Martin, W. & Croteau, R. (2000) Proc. Natl. Acad. Sci. USA 97, 13172-13177.
8. Rohdich, F., Kis, K., Bacher, A. & Eisenreich, W. (2001) Curr. Opin. Chem. Biol. 5, 535-540.
9. Sprenger, G. A., Schorken, U., Weigert, T., Grolle, S., de Graaf, A. A., Taylor, S. V., Begley, T. P., Bringer-Meyer, S. & Sahm, H. (1997) Proc. Natl. Acad. Sci. USA 25, 12857-12862.
10. Lois, L. M., Campos, N., Putra, S. R., Danielsen, K., Rohmer, M. & Boronat, A. (1998) Proc. Natl. Acad. Sci. USA 95, 2105-2110.
11. Takahashi, S., Kuzuyama, T., Watanabe, H. & Seto, H. (1998) Proc. Natl. Acad. Sci. USA 95, 9879-9884.
12. Kuzuyama, T., Takahashi, S., Takagi, M. & Seto, H. (2000) J. Biol. Chem. 30, 19928-19932.
13. Rohdich, F., Wungsintaweekul, J., Fellermeier, M., Sagner, S., Herz, S., Kis, K., Eisenreich, W., Bacher, A. & Zenk, M. H. (1999) Proc. Natl. Acad. Sci. USA 96, 11758-11763.
14. Kuzuyama, T., Takagi, M., Kaneda, K., Dairi, T. & Seto, H. (2000) Tetrahedron Lett. 41, 703-706.
15. Richard, S. B., Bowman, M. E., Kwiatkowski, W., Kang, I., Chow, C., Lillo, A. M., Cane, D. E. & Noel, J. P. (2001) Nat. Struct. Biol. 8, 641-647.
16. Lüttgen, H., Rohdich, F., Herz, S., Wungsintaweekul, J., Hecht, S., Schuhr, C. A., Fellermeier, M., Sagner, S., Zenk, M. H., Bacher, A. & Eisenreich, W. (1999) Proc. Natl. Acad. Sci. USA 97, 1062-1067.
17. Kuzuyama, T., Takagi, M., Kaneda, K., Watanabe, H., Dairi, T. & Seto, H. (2000) Tetrahedron Lett. 41, 2925-2928.
18. Takagi, M., Kuzuyama, T., Kaneda, K., Watanabe, H., Dairi, T. & Seto, H. (2000) Tetrahedron Lett. 41, 3395-3398.
19. Herz, S., Wungsintaweekul, J., Schuhr, C. A., Hecht, S., Lüttgen, H., Sagner, S., Fellermeier, M., Eisenreich, W., Zenk, M. H., Bacher, A. & Rohdich, F. (2000) Proc. Natl. Acad. Sci. USA 97, 2486-2490.
20. Altincicek, B., Duin, E. C., Reichenberg, A., Hedderich, R., Kollas, A. K., Hintz, M., Wagner, S., Wiesner, J., Beck, E. & Jomaa, H. (2002) FEBS Lett. 532, 437-440.
21. Kollas, A. K., Duin, E. C., Eberl, M., Altincicek, B., Hintz, M., Reichenberg, A., Henschker, D., Henne, A., Steinbrecher, I., Ostrovsky, D. N., et al. (2002) FEBS Lett. 532, 432-436.
22. Hecht, S., Eisenreich, W., Adam, P., Amslinger, S., Kis, K., Bacher, A., Arigoni, D. & Rohdich, F. (2001) Proc. Natl. Acad. Sci. USA 98, 14837-14842.
23. Rohdich, F., Hecht, S., Gärtner, K., Adam, P., Krieger, C., Amslinger, D., Arigoni, D., Bacher, A. & Eisenreich, W. (2002) Proc. Natl. Acad. Sci. USA 99, 1158-1163.
24. Kuzuyama, T., Shimizu, T., Takahashi, S. & Seto, H. (1998) Tetrahedron Lett. 39, 7913-7916.
25. Jomaa, H., Weisner, J., Sanderbrand, S., Altincicek, B., Weidemeyer, C., Hintz, M., Turbachova, I., Eberl, M., Zeidler, J., Lichtenthaler, H. K., et al. (1999) Science 285, 1573-1576.
26. Missinou, M. A., Borrmann, S., Schindler, A., Issifou, S., Adegnika, A. A., Matsiegui, P. B., Binder, R., Lell B., Wiesner, J., Baranek, T., et al. (2002) Lancet 360, 1941-1942.
27. Freiberg, C., Wieland, B., Spaltmann, F., Ehlert, K., Brotz, H. & Labischinski, H. (2001) J. Mol. Microbiol. Biotechnol. 3, 483-489.
28. Campos, N., Rodriguez-Concepcion, M., Sauret-Gueto, S., Gallego, F., Lois, L. M. & Boronat, A. (2001) Biochem. J. 353, 59-67.
29. Campbell, T. L. & Brown, E. D. (2002) J. Bacteriol. 184, 5609-5618.
30. Campos, N., Rodrguez-Concepcion, M., Seemann, M., Rohmer, M. & Boronat A. (2001) FEBS Lett. 488, 170-173.
31. Altincicek, B., Kollas, A., Eberl, M., Wiesner, J., Sanderbrand, S., Hintz, M., Beck, E. & Jomaa, H. (2001) FEBS Lett. 499, 37-40.
32. Reuter, K., Sanderbrand, S., Jomaa, H., Wiesner, J., Steinbrecher, I., Beck, E., Hintz, M., Klebe, G. & Stubbs, M. T. (2002) J. Biol. Chem. 277, 5378-5384.
33. Yajima, S., Nonaka, T., Kuzuyama, T., Seto, H. & Ohsawa, K. (2002) J. Biochem. (Tokyo) 131, 313-317.
34. Steinbacher, S., Kaiser, J., Eisenreich, W., Huber, R., Bacher, A. & Rohdich, F. (2003) J. Biol. Chem. 278, 18401-18407.
35. Kemp, L. E., Bond, C. S. & Hunter, W. N. (2003) Acta Crystallogr. D 59, 607-610.
36. Steinbacher, S., Kaiser, J., Wungsintaweekul, J., Hecht, S., Eisenreich, W., Gerhardt, S., Bacher, A. & Rohdich, F. (2002) J. Mol. Biol. 316, 79-88.
37. Richard, S. B., Ferrer, J.-L., Bowman, M. E., Lillo, A. M., Tetzlaff, C. N., Cane, D. E. & Noel, J. P. (2002) J. Biol. Chem. 277, 8667-8672.
38. Kemp, L. E., Bond, C. S. & Hunter, W. N. (2002) Proc. Natl. Acad. Sci. USA 99, 6591-6596.
39. Kishida, H., Wada, T., Unzai, S., Kuzuyama, T., Takagi, M., Terada, T., Shirouzu, M., Yokoyama, S., Tame, J. R. H. & Park, S.-Y. (2003) Acta Crystallogr. D 59, 23-31.
40. Krishna, S. S., Zhou, T., Daugherty, M., Osterman, A. L. & Zhang, H. (2001) Biochemistry 40, 10810-10818.
41. Bork, P., Sander, C. & Valencia, A. (1993) Protein Sci. 2, 31-40.
42. Bonanno, J. B., Edo, C., Eswar, N., Pieper, U., Romanowski, M. J., Ilyin, V., Gerchman, S. E., Kycia, H., Studier, F. W., Sali, A. & Burley, S. K. (2001) Proc. Natl. Acad. Sci. USA 98, 12896-12901.
43. Daugherty, M., Vonstein V., Overbeek, R. & Osterman, A. (2001) J. Bacteriol. 183, 292-300.
44. Zhou, T., Daugherty, M., Grishin, N. V., Osterman, A. L. & Zhang, H. (2000) Structure (London) 8, 1247-1257.
45. Fu, Z., Wang, M., Potter, D., Miziorko, H. M. & Kim, J.-J. (2002) J. Biol. Chem. 277, 18134-18142.
46. Yang, D., Shipman, L. W., Roessner, C. A., Scott, A. I. & Sacchettini J. C. (2002) J. Biol. Chem. 277, 9462-9467.
47. Romanowski, M. J., Bonanno, J. B. & Burley, S. K. (2002) Proteins 47, 568-571.
48. Rohdich, F., Schuhr, C. A., Hecht, S., Herz, S., Wungsintaweekul, J., Eisenreich, W., Zenk, M. H. & Bacher, A. (2000) J. Am. Chem. Soc. 122, 9571-9594.
49. Otwinowski, Z. & Minor, W. (1996) Methods Enzymol. 276, 307-326.
50. Terwilliger, T. C. & Berendzen, J. (1999) Acta Crystallogr. D 55, 849-861.
51. Terwilliger, T. C. (2000) Acta Crystallogr. D 56, 965-972.
52. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119.
53. Perrakis, A., Morris, R. & Lamzin, V. S. (1999) Nat. Struct. Biol. 6, 458-463.
54. Murshodov, G. N., Vagin, A. A. & Dodson, E. J. (1997) Acta Crystallogr. D 53, 240-255.
55. Collaborative Computational Project No. 4 (1994) Acta Crystallogr. D 50, 760-764.
56. Kleywegt, G. J. & Brünger, A. T. (1996) Structure (London) 4, 897-904.
57. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
58. Merritt, E. A. & Bacon, D. J. (1997) Methods Enzymol. 277, 505-524.
59. Hutchinson, E. G. & Thornton, J. M. (1996) Protein Sci. 5, 212-220.
60. Cheek, S., Zhang, H. & Grishin, N. V. (2002) J. Mol. Biol. 320, 855-881.
61. Knowles, J. (2003) Science 299, 2002-2003.
62. Holm, L. & Sander, C. (1995) Trends Biochem. Sci. 20, 478-480.
63. Thomson, J. D., Higgins, D. G. & Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680.